Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Roman Picazo-Frutos
- Quentin Stern
- John W Blanchard
- Olivier Cala
- Morgan Ceillier
- Samuel F Cousin
- James Eills
- Stuart J Elliott
- Sami Jannin
- Dmitry Budker
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000905359200001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/acs.analchem.2c02649
- eISSN
- 1520-6882
- Externe Identifier
- Clarivate Analytics Document Solution ID: E2PE3
- PubMed Identifier: 36563171
- ISSN
- 0003-2700
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- ANALYTICAL CHEMISTRY
- Paginierung
- 720 - 729
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Titel
- Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization
- Sub types
- Article
- Ausgabe der Zeitschrift
- 95
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Román Picazo-Frutos
- Quentin Stern
- John W Blanchard
- Olivier Cala
- Morgan Ceillier
- Samuel F Cousin
- James Eills
- Stuart J Elliott
- Sami Jannin
- Dmitry Budker
- DOI
- 10.1021/acs.analchem.2c02649
- eISSN
- 1520-6882
- ISSN
- 0003-2700
- Zeitschrift
- Analytical Chemistry
- Sprache
- en
- Online publication date
- 2022
- Status
- Published online
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/acs.analchem.2c02649
- Datum der Datenerfassung
- 2023
- Titel
- Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization
Data source: Crossref
- Abstract
- Zero- to ultralow-field nuclear magnetic resonance is a modality of magnetic resonance experiment which does not require strong superconducting magnets. Contrary to conventional high-field nuclear magnetic resonance, it has the advantage of allowing high-resolution detection of nuclear magnetism through metal as well as within heterogeneous media. To achieve high sensitivity, it is common to couple zero-field nuclear magnetic resonance with hyperpolarization techniques. To date, the most common technique is parahydrogen-induced polarization, which is only compatible with a small number of compounds. In this article, we establish dissolution dynamic nuclear polarization as a versatile method to enhance signals in zero-field nuclear magnetic resonance experiments on sample mixtures of [<sup>13</sup>C]sodium formate, [1-<sup>13</sup>C]glycine, and [2-<sup>13</sup>C]sodium acetate, and our technique is immediately extendable to a broad range of molecules with >1 s relaxation times. We find signal enhancements of up to 11,000 compared with thermal prepolarization in a 2 T permanent magnet. To increase the signal in future experiments, we investigate the relaxation effects of the TEMPOL radicals used for the hyperpolarization process at zero- and ultralow-fields.
- Addresses
- Helmholtz-Institut Mainz, GSI Helmholtzzentrum für Schwerionenforschung, Mainz55128, Germany.
- Autoren
- Román Picazo-Frutos
- Quentin Stern
- John W Blanchard
- Olivier Cala
- Morgan Ceillier
- Samuel F Cousin
- James Eills
- Stuart J Elliott
- Sami Jannin
- Dmitry Budker
- DOI
- 10.1021/acs.analchem.2c02649
- eISSN
- 1520-6882
- Externe Identifier
- PubMed Identifier: 36563171
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: 465084791
- European Research Council: 695405
- H2020 Marie Sklodowska-Curie Actions: 766402
- Deutsche Forschungsgemeinschaft: 39083149
- European Research Council: 714519
- Open access
- false
- ISSN
- 0003-2700
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Analytical chemistry
- Schlüsselwörter
- Magnetic Resonance Imaging
- Magnetic Resonance Spectroscopy
- Solubility
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Paginierung
- 720 - 729
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Datum der Datenerfassung
- 2022
- Titel
- Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 95
Data source: Europe PubMed Central
- Abstract
- Zero- to ultralow-field nuclear magnetic resonance is a modality of magnetic resonance experiment which does not require strong superconducting magnets. Contrary to conventional high-field nuclear magnetic resonance, it has the advantage of allowing high-resolution detection of nuclear magnetism through metal as well as within heterogeneous media. To achieve high sensitivity, it is common to couple zero-field nuclear magnetic resonance with hyperpolarization techniques. To date, the most common technique is parahydrogen-induced polarization, which is only compatible with a small number of compounds. In this article, we establish dissolution dynamic nuclear polarization as a versatile method to enhance signals in zero-field nuclear magnetic resonance experiments on sample mixtures of [13C]sodium formate, [1-13C]glycine, and [2-13C]sodium acetate, and our technique is immediately extendable to a broad range of molecules with >1 s relaxation times. We find signal enhancements of up to 11,000 compared with thermal prepolarization in a 2 T permanent magnet. To increase the signal in future experiments, we investigate the relaxation effects of the TEMPOL radicals used for the hyperpolarization process at zero- and ultralow-fields.
- Autoren
- Román Picazo-Frutos
- Quentin Stern
- John W Blanchard
- Olivier Cala
- Morgan Ceillier
- Samuel F Cousin
- James Eills
- Stuart J Elliott
- Sami Jannin
- Dmitry Budker
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36563171
- DOI
- 10.1021/acs.analchem.2c02649
- eISSN
- 1520-6882
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Anal Chem
- Schlüsselwörter
- Solubility
- Magnetic Resonance Spectroscopy
- Magnetic Resonance Imaging
- Sprache
- eng
- Country
- United States
- Paginierung
- 720 - 729
- Datum der Veröffentlichung
- 2023
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2023
- Titel
- Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 95
Data source: PubMed
- Author's licence
- InCopyright
- Autoren
- Román Picazo-Frutos
- Quentin Stern
- John W Blanchard
- Olivier Cala
- Morgan Ceillier
- Samuel F Cousin
- James Eills
- Stuart J Elliott
- Sami Jannin
- Dmitry Budker
- Hosting institution
- Universitätsbibliothek Mainz
- Resource version
- Published version
- DOI
- 10.1021/acs.analchem.2c02649
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 0003-2700
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Analytical chemistry
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 720 - 729
- Herausgeber
- ACS Publ.
- Zugang
- Deleted
- Titel
- Zero- to ultralow-field nuclear magnetic resonance enhanced with dissolution dynamic nuclear polarization
- Ausgabe der Zeitschrift
- 95
Files
zero_to_ultralowfield_nuclear-20231017205143651.pdf
Data source: OPENSCIENCE.UB
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