Spin Hyperpolarization in Modern Magnetic Resonance

Autoren

James Eills
Dmitry Budker
Silvia Cavagnero
Eduard Y Chekmenev
Stuart J Elliott
Sami Jannin
Anne Lesage
Jörg Matysik
Thomas Meersmann
Thomas Prisner
Jeffrey A Reimer
Hanming Yang
Igor V Koptyug

DOI

10.1021/acs.chemrev.2c00534

eISSN

1520-6890

ISSN

0009-2665

Ausgabe der Veröffentlichung

4

Zeitschrift

Chemical Reviews

Sprache

en

Online publication date

2023

Paginierung

1417 - 1551

Datum der Veröffentlichung

2023

Status

Published

Herausgeber

American Chemical Society (ACS)

Herausgeber URL

http://dx.doi.org/10.1021/acs.chemrev.2c00534

Datum der Datenerfassung

2023

Titel

Spin Hyperpolarization in Modern Magnetic Resonance

Ausgabe der Zeitschrift

123

Data source: Crossref

Abstract

Magnetic resonance techniques are successfully utilized in a broad range of scientific disciplines and in various practical applications, with medical magnetic resonance imaging being the most widely known example. Currently, both fundamental and applied magnetic resonance are enjoying a major boost owing to the rapidly developing field of spin hyperpolarization. Hyperpolarization techniques are able to enhance signal intensities in magnetic resonance by several orders of magnitude, and thus to largely overcome its major disadvantage of relatively low sensitivity. This provides new impetus for existing applications of magnetic resonance and opens the gates to exciting new possibilities. In this review, we provide a unified picture of the many methods and techniques that fall under the umbrella term "hyperpolarization" but are currently seldom perceived as integral parts of the same field. Specifically, before delving into the individual techniques, we provide a detailed analysis of the underlying principles of spin hyperpolarization. We attempt to uncover and classify the origins of hyperpolarization, to establish its sources and the specific mechanisms that enable the flow of polarization from a source to the target spins. We then give a more detailed analysis of individual hyperpolarization techniques: the mechanisms by which they work, fundamental and technical requirements, characteristic applications, unresolved issues, and possible future directions. We are seeing a continuous growth of activity in the field of spin hyperpolarization, and we expect the field to flourish as new and improved hyperpolarization techniques are implemented. Some key areas for development are in prolonging polarization lifetimes, making hyperpolarization techniques more generally applicable to chemical/biological systems, reducing the technical and equipment requirements, and creating more efficient excitation and detection schemes. We hope this review will facilitate the sharing of knowledge between subfields within the broad topic of hyperpolarization, to help overcome existing challenges in magnetic resonance and enable novel applications.

Addresses

Institute for Bioengineering of Catalonia, Barcelona Institute of Science and Technology, 08028Barcelona, Spain.

Autoren

James Eills
Dmitry Budker
Silvia Cavagnero
Eduard Y Chekmenev
Stuart J Elliott
Sami Jannin
Anne Lesage
Jörg Matysik
Thomas Meersmann
Thomas Prisner
Jeffrey A Reimer
Hanming Yang
Igor V Koptyug

DOI

10.1021/acs.chemrev.2c00534

eISSN

1520-6890

Externe Identifier

PubMed Identifier: 36701528
PubMed Central ID: PMC9951229

Funding acknowledgements

Russian Science Foundation: 22-43-04426
Deutsche Forschungsgemeinschaft: 465084791
European Research Council: 695405
National Institute of Biomedical Imaging and Bioengineering: R01EB029829
National Heart, Lung, and Blood Institute: R21HL154032
Centre National de la Recherche Scientifique:
Dutch Research Council (NWO):
European Research Council: 714519
Division of Chemistry: CHE-1904780
Division of Molecular and Cellular Biosciences: MCB 2124672
Deutsche Forschungsgemeinschaft: PRISMA+ EXC 2118/1
NIBIB NIH HHS: R01 EB029829
NIH HHS: S10 OD012245
U.S. Department of Defense: W81XWH-20-10576
NIGMS NIH HHS: R01 GM125995
H2020 Marie Sklodowska-Curie Actions: 766402
Division of Chemical, Bioengineering, Environmental, and Transport Systems: CBET-1912259
Office of the Director: S10OD012245
NHLBI NIH HHS: R21 HL154032
Bruker BioSpin:
Universit? Claude Bernard Lyon 1:
National Institute of General Medical Sciences: R01GM125995
?cole Normale Sup?rieure de Lyon:
Barcelona Institute of Science and Technology:
Volkswagen Foundation:
H2020 Excellent Science: 101008500
H2020 Marie Sklodowska-Curie Actions: 101063517
Deutsche Forschungsgemeinschaft: 39083149
Deutsche Forschungsgemeinschaft: 505655990
U.S. Department of Energy: BES-DE-SC0020638

Open access

true

ISSN

0009-2665

Ausgabe der Veröffentlichung

4

Zeitschrift

Chemical reviews

Sprache

eng

Medium

Print-Electronic

Online publication date

2023

Open access status

Open Access

Paginierung

1417 - 1551

Datum der Veröffentlichung

2023

Status

Published

Publisher licence

CC BY

Datum der Datenerfassung

2023

Titel

Spin Hyperpolarization in Modern Magnetic Resonance.

Sub types

review-article
Review
Journal Article

Ausgabe der Zeitschrift

123

Files

https://europepmc.org/articles/PMC9951229?pdf=render

Data source: Europe PubMed Central

Abstract

Magnetic resonance techniques are successfully utilized in a broad range of scientific disciplines and in various practical applications, with medical magnetic resonance imaging being the most widely known example. Currently, both fundamental and applied magnetic resonance are enjoying a major boost owing to the rapidly developing field of spin hyperpolarization. Hyperpolarization techniques are able to enhance signal intensities in magnetic resonance by several orders of magnitude, and thus to largely overcome its major disadvantage of relatively low sensitivity. This provides new impetus for existing applications of magnetic resonance and opens the gates to exciting new possibilities. In this review, we provide a unified picture of the many methods and techniques that fall under the umbrella term "hyperpolarization" but are currently seldom perceived as integral parts of the same field. Specifically, before delving into the individual techniques, we provide a detailed analysis of the underlying principles of spin hyperpolarization. We attempt to uncover and classify the origins of hyperpolarization, to establish its sources and the specific mechanisms that enable the flow of polarization from a source to the target spins. We then give a more detailed analysis of individual hyperpolarization techniques: the mechanisms by which they work, fundamental and technical requirements, characteristic applications, unresolved issues, and possible future directions. We are seeing a continuous growth of activity in the field of spin hyperpolarization, and we expect the field to flourish as new and improved hyperpolarization techniques are implemented. Some key areas for development are in prolonging polarization lifetimes, making hyperpolarization techniques more generally applicable to chemical/biological systems, reducing the technical and equipment requirements, and creating more efficient excitation and detection schemes. We hope this review will facilitate the sharing of knowledge between subfields within the broad topic of hyperpolarization, to help overcome existing challenges in magnetic resonance and enable novel applications.

Autoren

James Eills
Dmitry Budker
Silvia Cavagnero
Eduard Y Chekmenev
Stuart J Elliott
Sami Jannin
Anne Lesage
Jörg Matysik
Thomas Meersmann
Thomas Prisner
Jeffrey A Reimer
Hanming Yang
Igor V Koptyug

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/36701528

DOI

10.1021/acs.chemrev.2c00534

eISSN

1520-6890

Externe Identifier

PubMed Central ID: PMC9951229

Funding acknowledgements

NIBIB NIH HHS: R01 EB029829
NIGMS NIH HHS: R01 GM125995
NHLBI NIH HHS: R21 HL154032
NIH HHS: S10 OD012245

Ausgabe der Veröffentlichung

4

Zeitschrift

Chem Rev

Sprache

eng

Country

United States

Paginierung

1417 - 1551

Datum der Veröffentlichung

2023

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2023

Titel

Spin Hyperpolarization in Modern Magnetic Resonance.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

123

Data source: PubMed

Author's licence

CC-BY

Autoren

James Eills
Dmitry Budker
Silvia Cavagnero
Eduard Y Chekmenev
Stuart J Elliott
Sami Jannin
Anne Lesage
Jörg Matysik
Thomas Meersmann
Thomas Prisner
Jeffrey A Reimer
Hanming Yang
Igor V Koptyug

Hosting institution

Universitätsbibliothek Mainz

Sammlungen

JGU-Publikationen

Resource version

Published version

DOI

10.1021/acs.chemrev.2c00534

File(s) embargoed

false

Open access

true

ISSN

0009-2665

Ausgabe der Veröffentlichung

4

Zeitschrift

Chemical reviews

Schlüsselwörter

530 Physik
530 Physics
540 Chemie
540 Chemistry and allied sciences

Sprache

eng

Open access status

Open Access

Paginierung

1417 - 1551

Datum der Veröffentlichung

2023

Public URL

https://openscience.ub.uni-mainz.de/handle/20.500.12030/9641

Herausgeber

ACS Publ.

Datum der Datenerfassung

2023

Datum, an dem der Datensatz öffentlich gemacht wurde

2023

Zugang

Public

Titel

Spin hyperpolarization in modern magnetic resonance

Ausgabe der Zeitschrift

123

Files

spin_hyperpolarization_in_mod-20231017204804274.pdf

Data source: OPENSCIENCE.UB

Spin Hyperpolarization in Modern Magnetic Resonance

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