Much higher prevalence of keratoconus than announced results of the Gutenberg Health Study (GHS)

Publication type:
Journal article
Metadata:
Abstract
<jats:sec> <jats:title>Abstract </jats:title> <jats:p>Keratoconus appears to be a rare corneal disease with a prevalence previously estimated at 1:2000. The aim of our study was to investigate the prevalence of keratoconus in a large German cohort and to evaluate possible associated factors.</jats:p> </jats:sec><jats:sec> <jats:title>Method</jats:title> <jats:p>In the population-based, prospective, monocentric cohort study, Gutenberg Health Study, 12,423 subjects aged 40–80 years were examined at the 5-year follow-up. Subjects underwent a detailed medical history and a general and ophthalmologic examination including Scheimpflug imaging. Keratoconus diagnosis was performed in two steps: all subjects with conspicuous TKC analysis of corneal tomography were included in further grading.</jats:p> <jats:p>Prevalence and 95% confidence intervals were calculated. Logistic regression analysis was carried out to investigate association with age, sex, BMI, thyroid hormone, smoking, diabetes, arterial hypertension, atopy, allergy, steroid use, sleep apnea, asthma, and depression.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Of 10,419 subjects, 75 eyes of 51 subjects were classified as having keratoconus. The prevalence for keratoconus in the German cohort was 0.49% (1:204; 95% CI: 0.36–0.64%) and was approximately equally distributed across the age decades. No gender predisposition could be demonstrated.</jats:p> <jats:p>Logistic regression showed no association between keratoconus and age, sex, BMI, thyroid hormone, smoking, diabetes, arterial hypertension, atopy, allergy, steroid use, sleep apnea, asthma, and depression in our sample.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The prevalence of keratoconus disease in a mainly Caucasian population is approximately tenfold higher than previously reported in the literature using latest technologies (Scheimpflug imaging). Contrary to previous assumptions, we did not find associations with sex, existing atopy, thyroid dysfunction, diabetes, smoking, and depression.</jats:p> </jats:sec>
Autoren
  • Susanne Marx-Gross
  • Achim Fieß
  • Thomas Münzel
  • Philipp Sebastian Wild
  • Manfred Elmar Beutel
  • Irene Schmidtmann
  • Karl Johannes Lackner
  • Norbert Pfeiffer
  • Alexander Karl-Georg Schuster
DOI
10.1007/s00417-023-06132-y
eISSN
1435-702X
ISSN
0721-832X
Ausgabe der Veröffentlichung
11
Zeitschrift
Graefe's Archive for Clinical and Experimental Ophthalmology
Sprache
en
Online publication date
2023
Paginierung
3241 - 3247
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00417-023-06132-y
Datum der Datenerfassung
2023
Titel
Much higher prevalence of keratoconus than announced results of the Gutenberg Health Study (GHS)
Ausgabe der Zeitschrift
261

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Susanne Marx-Gross
  • Achim Fieß
  • Thomas Münzel
  • Philipp Sebastian Wild
  • Manfred Elmar Beutel
  • Irene Schmidtmann
  • Karl Johannes Lackner
  • Norbert Pfeiffer
  • Alexander Karl-Georg Schuster
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-H
Resource version
Published version
DOI
10.1007/s00417-023-06132-y
File(s) embargoed
false
Open access
true
ISSN
1435-702X
Zeitschrift
Graefe's archive for clinical and experimental ophthalmology
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Datum der Veröffentlichung
2023
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/9420
Herausgeber
Springer
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Much higher prevalence of keratoconus than announced results of the Gutenberg Health Study (GHS)
Ausgabe der Zeitschrift
Version of Record (VoR)

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much_higher_prevalence_of_ker-20230815144043541.pdf

Data source: OPENSCIENCE.UB

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