S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress

Publication type:
Journal article
Metadata:
Autoren
  • Isabel Denzer
  • Gerald Muench
  • Monika Pischetsrieder
  • Kristina Friedland
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000364248900108&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.foodchem.2015.08.052
eISSN
1873-7072
Externe Identifier
  • Clarivate Analytics Document Solution ID: CV4PL
  • PubMed Identifier: 26471626
ISSN
0308-8146
Zeitschrift
FOOD CHEMISTRY
Schlüsselwörter
  • Mitochondrial dysfunction
  • Oxidative stress
  • Nrf2
  • Alzheimer's disease
  • Aging
Paginierung
843 - 848
Datum der Veröffentlichung
2016
Status
Published
Titel
S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress
Sub types
  • Article
Ausgabe der Zeitschrift
194

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Isabel Denzer
  • Gerald Münch
  • Monika Pischetsrieder
  • Kristina Friedland
DOI
10.1016/j.foodchem.2015.08.052
ISSN
0308-8146
Zeitschrift
Food Chemistry
Sprache
en
Paginierung
843 - 848
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.foodchem.2015.08.052
Datum der Datenerfassung
2019
Titel
S-allyl-l-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress
Ausgabe der Zeitschrift
194

Data source: Crossref

Abstract
Oxidative and nitrosative stress resulting in mitochondrial dysfunction are an early event in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid-2-related factor 2 (Nrf2) is a key transcription factor and regulator of the cellular response to oxidative stress. Thus known Nrf2 activators from food materials were tested for improvement of mitochondrial membrane potential (MMP) and ATP level in neuronal pheochromocytoma cell (PC12) models of oxidative and nitrosative stress. The effects of rotenone and sodium nitroprusside (complex inhibitors of the respiratory chain) on mitochondrial function were also studied. Furthermore, Nrf2 activators were tested in human embryonic kidney cells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellular model of familial AD. Preincubation with S-allyl-l-cysteine and isoliquiritigenin increased MMP in both PC12 cell models in a similar range as the positive control l-sulforaphane. None of the test compounds, however, improved MMP and ATP level in APP(sw) HEK cells.
Addresses
  • Department of Chemistry and Pharmacy, Molecular and Clinical Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Cauerstr. 4, Haus 6, 91058 Erlangen, Germany; Department of Chemistry and Pharmacy, Emil Fischer Center, Henriette Schmidt-Burkhardt Chair of Food Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Schuhstr. 19, 91052 Erlangen, Germany. Electronic address: isabel.denzer@fau.de.
Autoren
  • Isabel Denzer
  • Gerald Münch
  • Monika Pischetsrieder
  • Kristina Friedland
DOI
10.1016/j.foodchem.2015.08.052
eISSN
1873-7072
Externe Identifier
  • PubMed Identifier: 26471626
Funding acknowledgements
  • FAU Emerging Fields Initiative:
Open access
false
ISSN
1873-7072
Zeitschrift
Food chemistry
Schlüsselwörter
  • Mitochondria
  • Animals
  • Humans
  • Rats
  • Alzheimer Disease
  • Chalcones
  • Cysteine
  • Oxidation-Reduction
  • Oxidative Stress
  • Aging
Sprache
eng
Medium
Print-Electronic
Online publication date
2015
Paginierung
843 - 848
Datum der Veröffentlichung
2016
Status
Published
Datum der Datenerfassung
2015
Titel
S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
194

Data source: Europe PubMed Central

Abstract
Oxidative and nitrosative stress resulting in mitochondrial dysfunction are an early event in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid-2-related factor 2 (Nrf2) is a key transcription factor and regulator of the cellular response to oxidative stress. Thus known Nrf2 activators from food materials were tested for improvement of mitochondrial membrane potential (MMP) and ATP level in neuronal pheochromocytoma cell (PC12) models of oxidative and nitrosative stress. The effects of rotenone and sodium nitroprusside (complex inhibitors of the respiratory chain) on mitochondrial function were also studied. Furthermore, Nrf2 activators were tested in human embryonic kidney cells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellular model of familial AD. Preincubation with S-allyl-l-cysteine and isoliquiritigenin increased MMP in both PC12 cell models in a similar range as the positive control l-sulforaphane. None of the test compounds, however, improved MMP and ATP level in APP(sw) HEK cells.
Date of acceptance
2015
Autoren
  • Isabel Denzer
  • Gerald Münch
  • Monika Pischetsrieder
  • Kristina Friedland
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/26471626
DOI
10.1016/j.foodchem.2015.08.052
eISSN
1873-7072
Zeitschrift
Food Chem
Schlüsselwörter
  • Aging
  • Alzheimer’s disease
  • Mitochondrial dysfunction
  • Nrf2
  • Oxidative stress
  • Aging
  • Alzheimer Disease
  • Animals
  • Chalcones
  • Cysteine
  • Humans
  • Mitochondria
  • Oxidation-Reduction
  • Oxidative Stress
  • Rats
Sprache
eng
Country
England
Paginierung
843 - 848
PII
S0308-8146(15)01250-9
Datum der Veröffentlichung
2016
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2016
Titel
S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
194

Data source: PubMed

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