Pharmacist-Led Medication Reviews to Identify and Collaboratively Resolve Drug-Related Problems in Psychiatry - A Controlled, Clinical Trial
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Carolin Wolf
- Anne Pauly
- Andreas Mayr
- Teja Groemer
- Bernd Lenz
- Johannes Kornhuber
- Kristina Friedland
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000364398700070&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1371/journal.pone.0142011
- Externe Identifier
- Clarivate Analytics Document Solution ID: CV6RT
- PubMed Identifier: 26544202
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- PLOS ONE
- Artikelnummer
- ARTN e0142011
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- Pharmacist-Led Medication Reviews to Identify and Collaboratively Resolve Drug-Related Problems in Psychiatry - A Controlled, Clinical Trial
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Carolin Wolf
- Anne Pauly
- Andreas Mayr
- Teja Grömer
- Bernd Lenz
- Johannes Kornhuber
- Kristina Friedland
- DOI
- 10.1371/journal.pone.0142011
- Editoren
- Christopher G Davey
- eISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- PLOS ONE
- Sprache
- en
- Online publication date
- 2015
- Paginierung
- e0142011 - e0142011
- Status
- Published online
- Herausgeber
- Public Library of Science (PLoS)
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0142011
- Datum der Datenerfassung
- 2019
- Titel
- Pharmacist-Led Medication Reviews to Identify and Collaboratively Resolve Drug-Related Problems in Psychiatry – A Controlled, Clinical Trial
- Ausgabe der Zeitschrift
- 10
Data source: Crossref
- Abstract
- <h4>Aim of the study</h4>This prospective, controlled trial aimed to assess the effect of pharmacist-led medication reviews on the medication safety of psychiatric inpatients by the resolution of Drug-Related Problems (DRP). Both the therapy appropriateness measured with the Medication Appropriateness Index (MAI) and the number of unsolved DRP per patient were chosen as primary outcome measures.<h4>Methods</h4>Depending on their time of admission, 269 psychiatric patients that were admitted to a psychiatric university hospital were allocated in control (09/2012-03/2013) or intervention group (05/2013-12/2013). In both groups, DRP were identified by comprehensive medication reviews by clinical pharmacists at admission, during the hospital stay, and at discharge. In the intervention group, recommendations for identified DRP were compiled by the pharmacists and discussed with the therapeutic team. In the control group, recommendations were not provided except for serious or life threatening DRP. As a primary outcome measure, the changes in therapy appropriateness from admission to discharge as well as from admission to three months after discharge (follow-up) assessed with the MAI were compared between both groups. The second primary outcome was the number of unsolved DRP per patient after completing the study protocol. The DRP type, the relevance and the potential of drugs to cause DRP were also evaluated.<h4>Results</h4>The intervention led to a reduced MAI score by 1.4 points per patient (95% confidence interval [CI]: 0.8-2.0) at discharge and 1.3 points (95% CI: 0.7-1.9) at follow-up compared with controls. The number of unsolved DRP in the intervention group was 1.8 (95% CI: 1.5-2.1) less than in control.<h4>Conclusion</h4>The pharmaceutical medication reviews with interdisciplinary discussion of identified DRP appears to be a worthy strategy to improve medication safety in psychiatry as reflected by less unsolved DRP per patient and an enhanced appropriateness of therapy. The promising results of this trial likely warrant further research that evaluates direct clinical outcomes and health-related costs.<h4>Trial registration</h4>Deutsches Register Klinischer Studien (DRKS), DRKS00006358.
- Addresses
- Molecular & Clinical Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
- Autoren
- Carolin Wolf
- Anne Pauly
- Andreas Mayr
- Teja Grömer
- Bernd Lenz
- Johannes Kornhuber
- Kristina Friedland
- DOI
- 10.1371/journal.pone.0142011
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Identifier: 26544202
- PubMed Central ID: PMC4636233
- Open access
- true
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- PloS one
- Schlüsselwörter
- Humans
- Medication Errors
- Hospitalization
- Prospective Studies
- Cooperative Behavior
- Psychiatry
- Adolescent
- Adult
- Middle Aged
- Pharmacists
- Drug Utilization Review
- Female
- Male
- Young Adult
- Drug-Related Side Effects and Adverse Reactions
- Early Intervention, Educational
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2015
- Open access status
- Open Access
- Paginierung
- e0142011
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2015
- Titel
- Pharmacist-Led Medication Reviews to Identify and Collaboratively Resolve Drug-Related Problems in Psychiatry - A Controlled, Clinical Trial.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142011&type=printable https://europepmc.org/articles/PMC4636233?pdf=render
Data source: Europe PubMed Central
- Abstract
- AIM OF THE STUDY: This prospective, controlled trial aimed to assess the effect of pharmacist-led medication reviews on the medication safety of psychiatric inpatients by the resolution of Drug-Related Problems (DRP). Both the therapy appropriateness measured with the Medication Appropriateness Index (MAI) and the number of unsolved DRP per patient were chosen as primary outcome measures. METHODS: Depending on their time of admission, 269 psychiatric patients that were admitted to a psychiatric university hospital were allocated in control (09/2012-03/2013) or intervention group (05/2013-12/2013). In both groups, DRP were identified by comprehensive medication reviews by clinical pharmacists at admission, during the hospital stay, and at discharge. In the intervention group, recommendations for identified DRP were compiled by the pharmacists and discussed with the therapeutic team. In the control group, recommendations were not provided except for serious or life threatening DRP. As a primary outcome measure, the changes in therapy appropriateness from admission to discharge as well as from admission to three months after discharge (follow-up) assessed with the MAI were compared between both groups. The second primary outcome was the number of unsolved DRP per patient after completing the study protocol. The DRP type, the relevance and the potential of drugs to cause DRP were also evaluated. RESULTS: The intervention led to a reduced MAI score by 1.4 points per patient (95% confidence interval [CI]: 0.8-2.0) at discharge and 1.3 points (95% CI: 0.7-1.9) at follow-up compared with controls. The number of unsolved DRP in the intervention group was 1.8 (95% CI: 1.5-2.1) less than in control. CONCLUSION: The pharmaceutical medication reviews with interdisciplinary discussion of identified DRP appears to be a worthy strategy to improve medication safety in psychiatry as reflected by less unsolved DRP per patient and an enhanced appropriateness of therapy. The promising results of this trial likely warrant further research that evaluates direct clinical outcomes and health-related costs. TRIAL REGISTRATION: Deutsches Register Klinischer Studien (DRKS), DRKS00006358.
- Date of acceptance
- 2015
- Autoren
- Carolin Wolf
- Anne Pauly
- Andreas Mayr
- Teja Grömer
- Bernd Lenz
- Johannes Kornhuber
- Kristina Friedland
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/26544202
- DOI
- 10.1371/journal.pone.0142011
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Central ID: PMC4636233
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- PLoS One
- Schlüsselwörter
- Adolescent
- Adult
- Cooperative Behavior
- Drug Utilization Review
- Drug-Related Side Effects and Adverse Reactions
- Early Intervention, Educational
- Female
- Hospitalization
- Humans
- Male
- Medication Errors
- Middle Aged
- Pharmacists
- Prospective Studies
- Psychiatry
- Young Adult
- Sprache
- eng
- Country
- United States
- Paginierung
- e0142011
- PII
- PONE-D-15-08521
- Datum der Veröffentlichung
- 2015
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Pharmacist-Led Medication Reviews to Identify and Collaboratively Resolve Drug-Related Problems in Psychiatry - A Controlled, Clinical Trial.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 10
Data source: PubMed
- Beziehungen:
- Property of