Hyperforin: To Be or Not to Be an Activator of TRPC(6)

Publication type:
Chapter
Metadata:
Autoren
  • Kristina Friedland
  • Christian Harteneck
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000370600100001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/112_2015_25
ISBN-13
978-3-319-26563-6
Schlüsselwörter
  • Calcium homeostasis
  • Depression
  • Hyperforin
  • Ion channel
  • Protonophore
  • St. John's wort
  • TRP channel
Paginierung
1 - 24
Buchtitel
REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 169
Datum der Veröffentlichung
2015
Status
Published
Titel
Hyperforin: To Be or Not to Be an Activator of TRPC(6)
Ausgabe der Zeitschrift
169

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Kristina Friedland
  • Christian Harteneck
DOI
10.1007/112_2015_25
ISBN-13
9783319265636
Online publication date
2015
Paginierung
1 - 24
Buchtitel
Reviews of Physiology, Biochemistry and Pharmacology Vol. 169
Datum der Veröffentlichung
2015
Status
Published
Herausgeber
Springer International Publishing
Herausgeber URL
http://dx.doi.org/10.1007/112_2015_25
Datum der Datenerfassung
2023
Titel
Hyperforin: To Be or Not to Be an Activator of TRPC(6)

Data source: Crossref

Abstract
Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the pharmacological profile of the plant extract used in therapy of depression. We will summarize the different concepts described for hyperforin's antidepressive activity. Starting with unspecific protein-independent mechanisms due to changes in pH, we will summarize data of protein-based concepts beginning with concepts based on involvement of a variety of proteins and will finally present concepts based on the modulation of a single protein.
Addresses
  • Department of Molecular and Clinical Pharmacy, Friedrich-Alexander University Erlangen/Nuremberg, Cauerstr. 4, 91058, Erlangen, Germany. kristina.leuner@fau.de.
Autoren
  • Kristina Friedland
  • Christian Harteneck
DOI
10.1007/112_2015_25
Open access
false
Schlüsselwörter
  • Animals
  • Humans
  • Terpenes
  • Phloroglucinol
  • Drug Stability
  • TRPC Cation Channels
  • Cytochrome P-450 Enzyme Inducers
  • TRPC6 Cation Channel
Medium
Print
Paginierung
1 - 24
Datum der Veröffentlichung
2015
Status
Published
Datum der Datenerfassung
2015
Titel
Hyperforin: To Be or Not to Be an Activator of TRPC(6).
Ausgabe der Zeitschrift
169

Data source: Europe PubMed Central

Abstract
Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the pharmacological profile of the plant extract used in therapy of depression. We will summarize the different concepts described for hyperforin's antidepressive activity. Starting with unspecific protein-independent mechanisms due to changes in pH, we will summarize data of protein-based concepts beginning with concepts based on involvement of a variety of proteins and will finally present concepts based on the modulation of a single protein.
Autoren
  • Kristina Friedland
  • Christian Harteneck
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/26384487
DOI
10.1007/112_2015_25
Schlüsselwörter
  • Calcium homeostasis
  • Depression
  • Hyperforin
  • Ion channel
  • Protonophore
  • St. John's wort
  • TRP channel
  • Animals
  • Cytochrome P-450 Enzyme Inducers
  • Drug Stability
  • Humans
  • Phloroglucinol
  • TRPC Cation Channels
  • TRPC6 Cation Channel
  • Terpenes
Paginierung
1 - 24
Datum der Veröffentlichung
2015
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2016
Titel
Hyperforin: To Be or Not to Be an Activator of TRPC(6).
Ausgabe der Zeitschrift
169

Data source: PubMed

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