Antimicrobial tolerance and its role in the development of resistance: Lessons from enterococci

Publication type:
Chapter
Metadata:
Autoren
  • Rachel L Darnell
  • Olivia Paxie
  • Francesca O Todd Rose
  • Sali Morris
  • Alexandra L Krause
  • Ian R Monk
  • Matigan JB Smith
  • Timothy P Stinear
  • Gregory M Cook
  • Susanne Gebhard
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000916924100003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/bs.ampbs.2022.06.004
Paginierung
25 - 65
Buchtitel
ADVANCES IN MICROBIAL PHYSIOLOGY, VOL. 81
Datum der Veröffentlichung
2022
Status
Published
Titel
Antimicrobial tolerance and its role in the development of resistance: Lessons from enterococci
Ausgabe der Zeitschrift
81

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Rachel L Darnell
  • Olivia Paxie
  • Francesca O Todd Rose
  • Sali Morris
  • Alexandra L Krause
  • Ian R Monk
  • Matigan JB Smith
  • Timothy P Stinear
  • Gregory M Cook
  • Susanne Gebhard
DOI
10.1016/bs.ampbs.2022.06.004
ISBN-13
9780323989886
Paginierung
25 - 65
Buchtitel
Advances in Microbial Physiology
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier
Herausgeber URL
http://dx.doi.org/10.1016/bs.ampbs.2022.06.004
Datum der Datenerfassung
2023
Titel
Antimicrobial tolerance and its role in the development of resistance: Lessons from enterococci

Data source: Crossref

Abstract
Bacteria have developed resistance against every antimicrobial in clinical use at an alarming rate. There is a critical need for more effective use of antimicrobials to both extend their shelf life and prevent resistance from arising. Significantly, antimicrobial tolerance, i.e., the ability to survive but not proliferate during antimicrobial exposure, has been shown to precede the development of bona fide antimicrobial resistance (AMR), sparking a renewed and rapidly increasing interest in this field. As a consequence, problematic infections for the first time are now being investigated for antimicrobial tolerance, with increasing reports demonstrating in-host evolution of antimicrobial tolerance. Tolerance has been identified in a wide array of bacterial species to all bactericidal antimicrobials. Of particular interest are enterococci, which contain the opportunistic bacterial pathogens Enterococcus faecalis and Enterococcus faecium. Enterococci are one of the leading causes of hospital-acquired infection and possess intrinsic tolerance to a number of antimicrobial classes. Persistence of these infections in the clinic is of growing concern, particularly for the immunocompromised. Here, we review current known mechanisms of antimicrobial tolerance, and include an in-depth analysis of those identified in enterococci with implications for both the development and prevention of AMR.
Addresses
  • Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, New Zealand. Electronic address: rachel.darnell@otago.ac.nz.
Autoren
  • Rachel L Darnell
  • Olivia Paxie
  • Francesca O Todd Rose
  • Sali Morris
  • Alexandra L Krause
  • Ian R Monk
  • Matigan JB Smith
  • Timothy P Stinear
  • Gregory M Cook
  • Susanne Gebhard
DOI
10.1016/bs.ampbs.2022.06.004
Funding Acknowledgements
  • University of Otago:
  • Health Research Council of New Zealand:
Open access
false
Schlüsselwörter
  • Enterococcus
  • Enterococcus faecium
  • Anti-Infective Agents
  • Anti-Bacterial Agents
  • Drug Resistance, Bacterial
Medium
Print-Electronic
Online publication date
2022
Paginierung
25 - 65
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Antimicrobial tolerance and its role in the development of resistance: Lessons from enterococci.
Ausgabe der Zeitschrift
81

Data source: Europe PubMed Central

Abstract
Bacteria have developed resistance against every antimicrobial in clinical use at an alarming rate. There is a critical need for more effective use of antimicrobials to both extend their shelf life and prevent resistance from arising. Significantly, antimicrobial tolerance, i.e., the ability to survive but not proliferate during antimicrobial exposure, has been shown to precede the development of bona fide antimicrobial resistance (AMR), sparking a renewed and rapidly increasing interest in this field. As a consequence, problematic infections for the first time are now being investigated for antimicrobial tolerance, with increasing reports demonstrating in-host evolution of antimicrobial tolerance. Tolerance has been identified in a wide array of bacterial species to all bactericidal antimicrobials. Of particular interest are enterococci, which contain the opportunistic bacterial pathogens Enterococcus faecalis and Enterococcus faecium. Enterococci are one of the leading causes of hospital-acquired infection and possess intrinsic tolerance to a number of antimicrobial classes. Persistence of these infections in the clinic is of growing concern, particularly for the immunocompromised. Here, we review current known mechanisms of antimicrobial tolerance, and include an in-depth analysis of those identified in enterococci with implications for both the development and prevention of AMR.
Autoren
  • Rachel L Darnell
  • Olivia Paxie
  • Francesca O Todd Rose
  • Sali Morris
  • Alexandra L Krause
  • Ian R Monk
  • Matigan JB Smith
  • Timothy P Stinear
  • Gregory M Cook
  • Susanne Gebhard
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/36167442
DOI
10.1016/bs.ampbs.2022.06.004
Schlüsselwörter
  • Antimicrobial resistance
  • Antimicrobial tolerance
  • Enterococcus
  • Mechanisms
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug Resistance, Bacterial
  • Enterococcus
  • Enterococcus faecium
Paginierung
25 - 65
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Antimicrobial tolerance and its role in the development of resistance: Lessons from enterococci.
Ausgabe der Zeitschrift
81

Data source: PubMed

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