Cannibalism stress response in Bacillus subtilis
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Carolin Hoefler
- Judith Heckmann
- Anne Fritsch
- Philipp Popp
- Susanne Gebhard
- Georg Fritz
- Thorsten Maschert
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000370461500017&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1099/mic.0.000176
- eISSN
- 1465-2080
- Externe Identifier
- Clarivate Analytics Document Solution ID: DE2MN
- PubMed Identifier: 26364265
- ISSN
- 1350-0872
- Zeitschrift
- MICROBIOLOGY-SGM
- Paginierung
- 164 - 176
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Cannibalism stress response in <i>Bacillus subtilis</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 162
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Carolin Höfler
- Judith Heckmann
- Anne Fritsch
- Philipp Popp
- Susanne Gebhard
- Georg Fritz
- Thorsten Mascher
- DOI
- 10.1099/mic.0.000176
- eISSN
- 1465-2080
- ISSN
- 1350-0872
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Microbiology
- Sprache
- en
- Paginierung
- 164 - 176
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Microbiology Society
- Herausgeber URL
- http://dx.doi.org/10.1099/mic.0.000176
- Datum der Datenerfassung
- 2020
- Titel
- Cannibalism stress response in Bacillus subtilis
- Ausgabe der Zeitschrift
- 162
Data source: Crossref
- Abstract
- When faced with carbon source limitation, the Gram-positive soil organism Bacillus subtilis initiates a survival strategy called sporulation, which leads to the formation of highly resistant endospores that allow B. subtilis to survive even long periods of starvation. In order to avoid commitment to this energy-demanding and irreversible process, B. subtilis employs another strategy called 'cannibalism' to delay sporulation as long as possible. Cannibalism involves the production and secretion of two cannibalism toxins, sporulation delaying protein (SDP) and sporulation killing factor (SKF), which are able to lyse sensitive siblings. The lysed cells are thought to then provide nutrients for the cannibals to slow down or even prevent them from entering sporulation. In this study, we uncovered the role of the cell envelope stress response (CESR), especially the Bce-like antimicrobial peptide detoxification modules, in the cannibalism stress response during the stationary phase. SDP and SKF specifically induce Bce-like systems and some extracytoplasmic function σ factors in stationary-phase cultures, but only the latter provide some degree of protection. A full Bce response is only triggered by mature toxins, and not by toxin precursors. Our study provides insights into the close relationship between stationary-phase survival and the CESR of B. subtilis.
- Addresses
- Department Biology I, Ludwig-Maximilians-Universität München, Großhaderner Strasse 2-4, 82152 Planegg-Martinsried, Germany.
- Autoren
- Carolin Höfler
- Judith Heckmann
- Anne Fritsch
- Philipp Popp
- Susanne Gebhard
- Georg Fritz
- Thorsten Mascher
- DOI
- 10.1099/mic.0.000176
- eISSN
- 1465-2080
- Externe Identifier
- PubMed Identifier: 26364265
- Open access
- false
- ISSN
- 1350-0872
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Microbiology (Reading, England)
- Schlüsselwörter
- Bacillus subtilis
- Bacterial Proteins
- Bacterial Toxins
- Gene Expression Regulation, Bacterial
- Stress, Physiological
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 164 - 176
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- Cannibalism stress response in Bacillus subtilis.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 162
Data source: Europe PubMed Central
- Abstract
- When faced with carbon source limitation, the Gram-positive soil organism Bacillus subtilis initiates a survival strategy called sporulation, which leads to the formation of highly resistant endospores that allow B. subtilis to survive even long periods of starvation. In order to avoid commitment to this energy-demanding and irreversible process, B. subtilis employs another strategy called 'cannibalism' to delay sporulation as long as possible. Cannibalism involves the production and secretion of two cannibalism toxins, sporulation delaying protein (SDP) and sporulation killing factor (SKF), which are able to lyse sensitive siblings. The lysed cells are thought to then provide nutrients for the cannibals to slow down or even prevent them from entering sporulation. In this study, we uncovered the role of the cell envelope stress response (CESR), especially the Bce-like antimicrobial peptide detoxification modules, in the cannibalism stress response during the stationary phase. SDP and SKF specifically induce Bce-like systems and some extracytoplasmic function σ factors in stationary-phase cultures, but only the latter provide some degree of protection. A full Bce response is only triggered by mature toxins, and not by toxin precursors. Our study provides insights into the close relationship between stationary-phase survival and the CESR of B. subtilis.
- Autoren
- Carolin Höfler
- Judith Heckmann
- Anne Fritsch
- Philipp Popp
- Susanne Gebhard
- Georg Fritz
- Thorsten Mascher
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/26364265
- DOI
- 10.1099/mic.0.000176
- eISSN
- 1465-2080
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Microbiology (Reading)
- Schlüsselwörter
- Bacillus subtilis
- Bacterial Proteins
- Bacterial Toxins
- Gene Expression Regulation, Bacterial
- Stress, Physiological
- Sprache
- eng
- Country
- England
- Paginierung
- 164 - 176
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Cannibalism stress response in Bacillus subtilis.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 162
Data source: PubMed
- Beziehungen:
- Property of