Cell-Sized Confinements Alter Molecular Diffusion in Concentrated Polymer Solutions Due to Length-Dependent Wetting of Polymers

Publication type:
Journal article
Metadata:
Autoren
  • Yuki Kanakubo
  • Chiho Watanabe
  • Johtaro Yamamoto
  • Naoya Yanagisawa
  • Hiroki Sakuta
  • Arash Nikoubashman
  • Miho Yanagisawa
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001013686800001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/acsmaterialsau.3c00018
Externe Identifier
  • Clarivate Analytics Document Solution ID: R4RQ3
  • PubMed Identifier: 38089102
ISSN
2694-2461
Ausgabe der Veröffentlichung
5
Zeitschrift
ACS MATERIALS AU
Schlüsselwörter
  • macromolecular crowding
  • artificial cell
  • depletioneffect
  • FCS
  • fluorescence correlation spectroscopy
  • molecular simulation
Paginierung
442 - 449
Datum der Veröffentlichung
2023
Status
Published
Titel
Cell-Sized Confinements Alter Molecular Diffusion in Concentrated Polymer Solutions Due to Length-Dependent Wetting of Polymers
Sub types
  • Article
Ausgabe der Zeitschrift
3

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Yuki Kanakubo
  • Chiho Watanabe
  • Johtaro Yamamoto
  • Naoya Yanagisawa
  • Hiroki Sakuta
  • Arash Nikoubashman
  • Miho Yanagisawa
DOI
10.1021/acsmaterialsau.3c00018
eISSN
2694-2461
ISSN
2694-2461
Ausgabe der Veröffentlichung
5
Zeitschrift
ACS Materials Au
Sprache
en
Online publication date
2023
Paginierung
442 - 449
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/acsmaterialsau.3c00018
Datum der Datenerfassung
2023
Titel
Cell-Sized Confinements Alter Molecular Diffusion in Concentrated Polymer Solutions Due to Length-Dependent Wetting of Polymers
Ausgabe der Zeitschrift
3

Data source: Crossref

Abstract
Living cells are characterized by the micrometric confinement of various macromolecules at high concentrations. Using droplets containing binary polymer blends as artificial cells, we previously showed that cell-sized confinement causes phase separation of the binary polymer solutions because of the length-dependent wetting of the polymers. Here, we demonstrate that the confinement-induced heterogeneity of polymers also emerges in single-component polymer solutions. The resulting structural heterogeneity also leads to a slower transport of small molecules at the center of cell-sized droplets than that in bulk solutions. Coarse-grained molecular simulations support this confinement-induced heterogeneous distribution by polymer length and demonstrate that the effective wetting of the shorter chains at the droplet surface originates from the length-dependent conformational entropy. Our results suggest that cell-sized confinement functions as a structural regulator for polydisperse polymer solutions that specifically manipulates the diffusion of molecules, particularly those with sizes close to the correlation length of the polymer chains.
Addresses
  • Komaba Institute for Science, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro, Tokyo 153-8902, Japan.
Autoren
  • Yuki Kanakubo
  • Chiho Watanabe
  • Johtaro Yamamoto
  • Naoya Yanagisawa
  • Hiroki Sakuta
  • Arash Nikoubashman
  • Miho Yanagisawa
DOI
10.1021/acsmaterialsau.3c00018
eISSN
2694-2461
Externe Identifier
  • PubMed Identifier: 38089102
  • PubMed Central ID: PMC10510498
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: 470113688
  • Japan Society for the Promotion of Science: 20K14425
  • Japan Society for the Promotion of Science: 22H01188
  • Japan Science and Technology Agency: JPMJFR213Y
  • Japan Science and Technology Agency: JPMJAX191L
  • Japan Society for the Promotion of Science: 21H05871
Open access
true
ISSN
2694-2461
Ausgabe der Veröffentlichung
5
Zeitschrift
ACS materials Au
Sprache
eng
Medium
Electronic-eCollection
Online publication date
2023
Open access status
Open Access
Paginierung
442 - 449
Datum der Veröffentlichung
2023
Status
Published
Publisher licence
CC BY-NC-ND
Datum der Datenerfassung
2023
Titel
Cell-Sized Confinements Alter Molecular Diffusion in Concentrated Polymer Solutions Due to Length-Dependent Wetting of Polymers.
Sub types
  • rapid-communication
  • Journal Article
Ausgabe der Zeitschrift
3

Files

https://europepmc.org/articles/PMC10510498?pdf=render

Data source: Europe PubMed Central

Abstract
Living cells are characterized by the micrometric confinement of various macromolecules at high concentrations. Using droplets containing binary polymer blends as artificial cells, we previously showed that cell-sized confinement causes phase separation of the binary polymer solutions because of the length-dependent wetting of the polymers. Here, we demonstrate that the confinement-induced heterogeneity of polymers also emerges in single-component polymer solutions. The resulting structural heterogeneity also leads to a slower transport of small molecules at the center of cell-sized droplets than that in bulk solutions. Coarse-grained molecular simulations support this confinement-induced heterogeneous distribution by polymer length and demonstrate that the effective wetting of the shorter chains at the droplet surface originates from the length-dependent conformational entropy. Our results suggest that cell-sized confinement functions as a structural regulator for polydisperse polymer solutions that specifically manipulates the diffusion of molecules, particularly those with sizes close to the correlation length of the polymer chains.
Date of acceptance
2023
Autoren
  • Yuki Kanakubo
  • Chiho Watanabe
  • Johtaro Yamamoto
  • Naoya Yanagisawa
  • Hiroki Sakuta
  • Arash Nikoubashman
  • Miho Yanagisawa
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/38089102
DOI
10.1021/acsmaterialsau.3c00018
eISSN
2694-2461
Externe Identifier
  • PubMed Central ID: PMC10510498
Ausgabe der Veröffentlichung
5
Zeitschrift
ACS Mater Au
Sprache
eng
Country
United States
Paginierung
442 - 449
Datum der Veröffentlichung
2023
Status
Published online
Titel
Cell-Sized Confinements Alter Molecular Diffusion in Concentrated Polymer Solutions Due to Length-Dependent Wetting of Polymers.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
3

Data source: PubMed

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