Paramagnetic self-assembled nanoparticles as supramolecular MRI contrast agents

Abstract

Nanometer‐sized materials offer a wide range of applications in biomedical technologies, particularly imaging and diagnostics. Current scaffolds in the nanometer range predominantly make use of inorganic particles, organic polymers or natural peptide‐based macromolecules. In contrast we hereby report a supramolecular approach for the preparation of self‐assembled dendritic‐like nanoparticles for applications as MRI contrast agents. This strategy combines the benefits from low molecular weight imaging agents with the ones of high molecular weight. Their in vitro properties are confirmed by in vivo measurements: post injection of well‐defined and meta‐stable nanoparticles allows for high‐resolution blood‐pool imaging, even at very low Gd(III) doses. These dynamic and modular imaging agents are an important addition to the young field of supramolecular medicine using well‐defined nanometer‐sized assemblies. Copyright © 2012 John Wiley & Sons, Ltd.

Autoren

Pol Besenius
Joeri LM Heynens
Roel Straathof
Marko ML Nieuwenhuizen
Paul HH Bomans
Enzo Terreno
Silvio Aime
Gustav J Strijkers
Klaas Nicolay
EW Meijer

DOI

10.1002/cmmi.498

eISSN

1555-4317

ISSN

1555-4309

Ausgabe der Veröffentlichung

3

Zeitschrift

Contrast Media & Molecular Imaging

Sprache

en

Online publication date

2012

Paginierung

356 - 361

Datum der Veröffentlichung

2012

Status

Published

Herausgeber

Wiley

Herausgeber URL

http://dx.doi.org/10.1002/cmmi.498

Datum der Datenerfassung

2023

Titel

Paramagnetic self‐assembled nanoparticles as supramolecular MRI contrast agents

Ausgabe der Zeitschrift

7

Data source: Crossref

Abstract

Nanometer-sized materials offer a wide range of applications in biomedical technologies, particularly imaging and diagnostics. Current scaffolds in the nanometer range predominantly make use of inorganic particles, organic polymers or natural peptide-based macromolecules. In contrast we hereby report a supramolecular approach for the preparation of self-assembled dendritic-like nanoparticles for applications as MRI contrast agents. This strategy combines the benefits from low molecular weight imaging agents with the ones of high molecular weight. Their in vitro properties are confirmed by in vivo measurements: post injection of well-defined and meta-stable nanoparticles allows for high-resolution blood-pool imaging, even at very low Gd(III) doses. These dynamic and modular imaging agents are an important addition to the young field of supramolecular medicine using well-defined nanometer-sized assemblies.

Addresses

Institute for Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.

Autoren

Pol Besenius
Joeri LM Heynens
Roel Straathof
Marko ML Nieuwenhuizen
Paul HH Bomans
Enzo Terreno
Silvio Aime
Gustav J Strijkers
Klaas Nicolay
EW Meijer

DOI

10.1002/cmmi.498

eISSN

1555-4317

Externe Identifier

PubMed Identifier: 22539406

Funding acknowledgements

European Commission FP7: FP7_235914

Open access

false

ISSN

1555-4309

Ausgabe der Veröffentlichung

3

Zeitschrift

Contrast media & molecular imaging

Schlüsselwörter

Animals
Mice, Inbred C57BL
Mice
Gadolinium DTPA
Macromolecular Substances
Contrast Media
Magnetic Resonance Imaging
Brain Mapping
Male
Nanoparticles

Sprache

eng

Medium

Print

Paginierung

356 - 361

Datum der Veröffentlichung

2012

Status

Published

Datum der Datenerfassung

2012

Titel

Paramagnetic self-assembled nanoparticles as supramolecular MRI contrast agents.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

7

Data source: Europe PubMed Central

Abstract

Nanometer-sized materials offer a wide range of applications in biomedical technologies, particularly imaging and diagnostics. Current scaffolds in the nanometer range predominantly make use of inorganic particles, organic polymers or natural peptide-based macromolecules. In contrast we hereby report a supramolecular approach for the preparation of self-assembled dendritic-like nanoparticles for applications as MRI contrast agents. This strategy combines the benefits from low molecular weight imaging agents with the ones of high molecular weight. Their in vitro properties are confirmed by in vivo measurements: post injection of well-defined and meta-stable nanoparticles allows for high-resolution blood-pool imaging, even at very low Gd(III) doses. These dynamic and modular imaging agents are an important addition to the young field of supramolecular medicine using well-defined nanometer-sized assemblies.

Autoren

Pol Besenius
Joeri LM Heynens
Roel Straathof
Marko ML Nieuwenhuizen
Paul HH Bomans
Enzo Terreno
Silvio Aime
Gustav J Strijkers
Klaas Nicolay
EW Meijer

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/22539406

DOI

10.1002/cmmi.498

eISSN

1555-4317

Ausgabe der Veröffentlichung

3

Zeitschrift

Contrast Media Mol Imaging

Schlüsselwörter

Animals
Brain Mapping
Contrast Media
Gadolinium DTPA
Macromolecular Substances
Magnetic Resonance Imaging
Male
Mice
Mice, Inbred C57BL
Nanoparticles

Sprache

eng

Country

England

Paginierung

356 - 361

Datum der Veröffentlichung

2012

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2012

Titel

Paramagnetic self-assembled nanoparticles as supramolecular MRI contrast agents.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

7

Data source: PubMed

Paramagnetic self-assembled nanoparticles as supramolecular MRI contrast agents

Tools