Carotenoids for lung cancer chemoprevention and chemotherapy: Promises and controversies

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001001278600001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2023.154850
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: I2QK2
  • PubMed Identifier: 37187036
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Lung cancer
  • Carotenoids
  • Chemoprevention
  • Chemotherapy
  • Clinical trials
Artikelnummer
ARTN 154850
Datum der Veröffentlichung
2023
Status
Published
Titel
Carotenoids for lung cancer chemoprevention and chemotherapy: Promises and controversies
Sub types
  • Review
Ausgabe der Zeitschrift
116

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2023.154850
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
154850
Paginierung
154850 - 154850
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2023.154850
Datum der Datenerfassung
2024
Titel
Carotenoids for lung cancer chemoprevention and chemotherapy: Promises and controversies
Ausgabe der Zeitschrift
116

Data source: Crossref

Abstract
<h4>Background</h4>Lung cancer is one of the leading causes of malignancy in the world. Several therapeutical and chemopreventive approaches have been practised to mitigate the disease. The use of phytopigments including carotenoids is a well-known approach. However, some of the prominent clinical trials interrogated the efficacy of carotenoids in lung cancer prevention.<h4>Methods</h4>A elaborate literature survey have been performed investigating in vitro, in vivo, and clinical studies reported on the administration of carotenoids for chemoprevention and chemotherapy.<h4>Results</h4>Tobacco consumption, genetic factors, dietary patterns, occupational carcinogens, lung diseases, infection, and sex disparities are some of the prominent factors leading to lung cancer. Significant evidence has been found underlining the efficiency of carotenoids in alleviating cancer. In vitro studies have proven that carotenoids act through PI3K/ AKT/mTOR, ERK-MAPK pathways and induce apoptosis through PPAR, IFNs, RAR, which are p53 intermediators in lung cancer signaling. Animal models and cell lines studies showed promising results, while the outcomes of clinical trials are contradictory and require further verification.<h4>Conclusion</h4>The carotenoids exert chemotherapeutic and chemopreventive effects on lung tumors which has been evidenced in numerous investigations. However, further analyses are necessary to the answer the uncertainties raised by several clinical trials.
Addresses
  • Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute, Technology, Vellore 632014, India.
Autoren
DOI
10.1016/j.phymed.2023.154850
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 37187036
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Animals
  • Lung Neoplasms
  • Carotenoids
  • Anticarcinogenic Agents
  • Antioxidants
  • Chemoprevention
Sprache
eng
Medium
Print-Electronic
Online publication date
2023
Paginierung
154850
Datum der Veröffentlichung
2023
Status
Published
Datum der Datenerfassung
2023
Titel
Carotenoids for lung cancer chemoprevention and chemotherapy: Promises and controversies.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
116

Data source: Europe PubMed Central

Abstract
BACKGROUND: Lung cancer is one of the leading causes of malignancy in the world. Several therapeutical and chemopreventive approaches have been practised to mitigate the disease. The use of phytopigments including carotenoids is a well-known approach. However, some of the prominent clinical trials interrogated the efficacy of carotenoids in lung cancer prevention. METHODS: A elaborate literature survey have been performed investigating in vitro, in vivo, and clinical studies reported on the administration of carotenoids for chemoprevention and chemotherapy. RESULTS: Tobacco consumption, genetic factors, dietary patterns, occupational carcinogens, lung diseases, infection, and sex disparities are some of the prominent factors leading to lung cancer. Significant evidence has been found underlining the efficiency of carotenoids in alleviating cancer. In vitro studies have proven that carotenoids act through PI3K/ AKT/mTOR, ERK-MAPK pathways and induce apoptosis through PPAR, IFNs, RAR, which are p53 intermediators in lung cancer signaling. Animal models and cell lines studies showed promising results, while the outcomes of clinical trials are contradictory and require further verification. CONCLUSION: The carotenoids exert chemotherapeutic and chemopreventive effects on lung tumors which has been evidenced in numerous investigations. However, further analyses are necessary to the answer the uncertainties raised by several clinical trials.
Date of acceptance
2023
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/37187036
DOI
10.1016/j.phymed.2023.154850
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Carotenoids
  • Chemoprevention
  • Chemotherapy
  • Clinical trials
  • Lung cancer
  • Animals
  • Carotenoids
  • Lung Neoplasms
  • Chemoprevention
  • Anticarcinogenic Agents
  • Antioxidants
Sprache
eng
Country
Germany
Paginierung
154850
PII
S0944-7113(23)00211-8
Datum der Veröffentlichung
2023
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Titel
Carotenoids for lung cancer chemoprevention and chemotherapy: Promises and controversies.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
116

Data source: PubMed

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