A Dual-Sensing Receptor Confers Robust Cellular Homeostasis
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Hannah Schramke
- Filipe Tostevin
- Ralf Heermann
- Ulrich Gerland
- Kirsten Jung
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000378950700019&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.celrep.2016.05.081
- Externe Identifier
- Clarivate Analytics Document Solution ID: DQ1GY
- PubMed Identifier: 27320909
- ISSN
- 2211-1247
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- CELL REPORTS
- Paginierung
- 213 - 221
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- A Dual-Sensing Receptor Confers Robust Cellular Homeostasis
- Sub types
- Article
- Ausgabe der Zeitschrift
- 16
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Hannah Schramke
- Filipe Tostevin
- Ralf Heermann
- Ulrich Gerland
- Kirsten Jung
- DOI
- 10.1016/j.celrep.2016.05.081
- ISSN
- 2211-1247
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Cell Reports
- Sprache
- en
- Paginierung
- 213 - 221
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.celrep.2016.05.081
- Datum der Datenerfassung
- 2022
- Titel
- A Dual-Sensing Receptor Confers Robust Cellular Homeostasis
- Ausgabe der Zeitschrift
- 16
Data source: Crossref
- Abstract
- Cells have evolved diverse mechanisms that maintain intracellular homeostasis in fluctuating environments. In bacteria, control is often exerted by bifunctional receptors acting as both kinase and phosphatase to regulate gene expression, a design known to provide robustness against noise. Yet how such antagonistic enzymatic activities are balanced as a function of environmental change remains poorly understood. We find that the bifunctional receptor that regulates K(+) uptake in Escherichia coli is a dual sensor, which modulates its autokinase and phosphatase activities in response to both extracellular and intracellular K(+) concentration. Using mathematical modeling, we show that dual sensing is a superior strategy for ensuring homeostasis when both the supply of and demand for a limiting resource fluctuate. By engineering standards, this molecular control system displays a strikingly high degree of functional integration, providing a reference for the vast numbers of receptors for which the sensing strategy remains elusive.
- Addresses
- Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Großhaderner Straße 2-4, 82152 Martinsried, Germany; Department of Biology I, Microbiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 2-4, 82152 Martinsried, Germany.
- Autoren
- Hannah Schramke
- Filipe Tostevin
- Ralf Heermann
- Ulrich Gerland
- Kirsten Jung
- DOI
- 10.1016/j.celrep.2016.05.081
- eISSN
- 2211-1247
- Externe Identifier
- PubMed Identifier: 27320909
- Open access
- false
- ISSN
- 2211-1247
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Cell reports
- Schlüsselwörter
- Periplasm
- Escherichia coli
- Potassium
- Phosphoric Monoester Hydrolases
- Protein Kinases
- Escherichia coli Proteins
- Temperature
- Amino Acid Sequence
- Protein Structure, Secondary
- Homeostasis
- Models, Biological
- Mutant Proteins
- Stress, Physiological
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 213 - 221
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Publisher licence
- CC BY-NC-ND
- Datum der Datenerfassung
- 2016
- Titel
- A Dual-Sensing Receptor Confers Robust Cellular Homeostasis.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 16
Data source: Europe PubMed Central
- Abstract
- Cells have evolved diverse mechanisms that maintain intracellular homeostasis in fluctuating environments. In bacteria, control is often exerted by bifunctional receptors acting as both kinase and phosphatase to regulate gene expression, a design known to provide robustness against noise. Yet how such antagonistic enzymatic activities are balanced as a function of environmental change remains poorly understood. We find that the bifunctional receptor that regulates K(+) uptake in Escherichia coli is a dual sensor, which modulates its autokinase and phosphatase activities in response to both extracellular and intracellular K(+) concentration. Using mathematical modeling, we show that dual sensing is a superior strategy for ensuring homeostasis when both the supply of and demand for a limiting resource fluctuate. By engineering standards, this molecular control system displays a strikingly high degree of functional integration, providing a reference for the vast numbers of receptors for which the sensing strategy remains elusive.
- Date of acceptance
- 2016
- Autoren
- Hannah Schramke
- Filipe Tostevin
- Ralf Heermann
- Ulrich Gerland
- Kirsten Jung
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/27320909
- DOI
- 10.1016/j.celrep.2016.05.081
- eISSN
- 2211-1247
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Cell Rep
- Schlüsselwörter
- Amino Acid Sequence
- Escherichia coli
- Escherichia coli Proteins
- Homeostasis
- Models, Biological
- Mutant Proteins
- Periplasm
- Phosphoric Monoester Hydrolases
- Potassium
- Protein Kinases
- Protein Structure, Secondary
- Stress, Physiological
- Temperature
- Sprache
- eng
- Country
- United States
- Paginierung
- 213 - 221
- PII
- S2211-1247(16)30694-5
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- A Dual-Sensing Receptor Confers Robust Cellular Homeostasis.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 16
Data source: PubMed
- Beziehungen:
- Property of