The German S3 guideline on titanium hypersensitivity in implant dentistry: consensus statements and recommendations

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>There is currently a lack of guidelines for clinicians regarding titanium hypersensitivity in implant dentistry. Diagnostic tests such as the epicutaneous test or the lymphocyte transformation test showed inconsistent results regarding reliability and validity and thus, evidence-based consensus recommendations regarding diagnostic and therapeutic options may be helpful in clinical decision-making. Therefore, the German S3 guideline on titanium hypersensitivity in implant dentistry was developed.</jats:p> </jats:sec><jats:sec> <jats:title>Findings</jats:title> <jats:p>In the objectives, procedure, voting method and venue were defined and the consensus participants were invited. A systematic literature research was performed, and the overall quality of the evidence was rated according to the GRADE working group. Eight recommendations were formulated within the framework of a structured consensus conference under independent moderation and could be voted on with strong consensus (&gt; 95% agreement). The formulated statements and recommendations were developed in small groups according to the guidelines of the Association of the Scientific Medical Societies in Germany (AWMF) and were discussed and agreed upon in the plenum.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>For reasonable decision-making, a patient’s clinical symptoms should be regarded as leading parameters, which are usually expressed by a local inflammatory reaction with subsequent disturbed osseous integration. Allergy tests, such as the epicutaneous test or the lymphocyte transformation test are not helpful in titanium intolerance assessments, since these tests indicate T cell-mediated allergies, which are not observed in titanium intolerance reactions. Other metals and impurities that might be present in superstructures or alloys also need to be considered as the cause of an intolerance reaction and a trigger for contact sensitization. In the case of a suspected titanium particle-related, local immunologically induced inflammatory reaction with subsequent impaired osseous integration, dental ceramic implants can be considered as a therapeutic option.</jats:p> </jats:sec><jats:sec> <jats:title>Graphical Abstract</jats:title> </jats:sec>
Autoren
  • Lena Katharina Müller-Heupt
  • Eik Schiegnitz
  • Sebahat Kaya
  • Elisabeth Jacobi-Gresser
  • Peer Wolfgang Kämmerer
  • Bilal Al-Nawas
DOI
10.1186/s40729-022-00451-1
eISSN
2198-4034
Ausgabe der Veröffentlichung
1
Zeitschrift
International Journal of Implant Dentistry
Sprache
en
Artikelnummer
51
Online publication date
2022
Status
Published online
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1186/s40729-022-00451-1
Datum der Datenerfassung
2023
Titel
The German S3 guideline on titanium hypersensitivity in implant dentistry: consensus statements and recommendations
Ausgabe der Zeitschrift
8

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Lena Katharina Müller-Heupt
  • Eik Schiegnitz
  • Sebahat Kaya
  • Elisabeth Jacobi-Gresser
  • Peer Wolfgang Kämmerer
  • Bilal Al-Nawas
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.1186/s40729-022-00451-1
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
2198-4034
Zeitschrift
International journal of implant dentistry
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
51
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8910
Herausgeber
Springer
Herausgeber URL
https://doi.org/10.1186/s40729-022-00451-1
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
The German S3 guideline on titanium hypersensitivity in implant dentistry : consensus statements and recommendations
Ausgabe der Zeitschrift
8

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the_german_s3_guideline_on_ti-20230307121343791.pdf

Data source: OPENSCIENCE.UB

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