Coarse-grained simulations of membranes under tension

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000275825500047&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1063/1.3352583
eISSN
1089-7690
Externe Identifier
  • Clarivate Analytics Document Solution ID: 572IZ
  • PubMed Identifier: 20331316
ISSN
0021-9606
Ausgabe der Veröffentlichung
11
Zeitschrift
JOURNAL OF CHEMICAL PHYSICS
Schlüsselwörter
  • biomechanics
  • biomembranes
  • cellular biophysics
  • elasticity
  • fluids
  • gels
  • lipid bilayers
  • Monte Carlo methods
Artikelnummer
ARTN 115101
Datum der Veröffentlichung
2010
Status
Published
Titel
Coarse-grained simulations of membranes under tension
Sub types
  • Article
Ausgabe der Zeitschrift
132

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p>We investigate the properties of membranes under tension by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers. We give a comprising overview of the behavior of several membrane characteristics, such as the area per lipid, the monolayer overlap, the nematic order, and pressure profiles. Both the low-temperature regime, where the membranes are in a gel Lβ′ phase, and the high-temperature regime, where they are in the fluid Lα phase, are considered. In the Lβ′ state, the membrane is hardly influenced by tension. In the fluid state, high tensions lead to structural changes in the membrane, which result in different compressibility regimes. The ripple state Pβ′, which is found at tension zero in the transition regime between Lα and Lβ′, disappears under tension and gives way to an interdigitated phase. We also study the membrane fluctuations in the fluid phase. In the low-tension regime the data can be fitted nicely to a suitably extended elastic theory. At higher tensions the elastic fit consistently underestimates the strength of long-wavelength fluctuations. Finally, we investigate the influence of tension on the effective interaction between simple transmembrane inclusions and show that tension can be used to tune the hydrophobic mismatch interaction between membrane proteins.</jats:p>
Autoren
DOI
10.1063/1.3352583
eISSN
1089-7690
ISSN
0021-9606
Ausgabe der Veröffentlichung
11
Zeitschrift
The Journal of Chemical Physics
Sprache
en
Online publication date
2010
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
AIP Publishing
Herausgeber URL
http://dx.doi.org/10.1063/1.3352583
Datum der Datenerfassung
2023
Titel
Coarse-grained simulations of membranes under tension
Ausgabe der Zeitschrift
132

Data source: Crossref

Abstract
We investigate the properties of membranes under tension by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers. We give a comprising overview of the behavior of several membrane characteristics, such as the area per lipid, the monolayer overlap, the nematic order, and pressure profiles. Both the low-temperature regime, where the membranes are in a gel L(beta(')) phase, and the high-temperature regime, where they are in the fluid L(alpha) phase, are considered. In the L(beta(')) state, the membrane is hardly influenced by tension. In the fluid state, high tensions lead to structural changes in the membrane, which result in different compressibility regimes. The ripple state P(beta(')), which is found at tension zero in the transition regime between L(alpha) and L(beta(')), disappears under tension and gives way to an interdigitated phase. We also study the membrane fluctuations in the fluid phase. In the low-tension regime the data can be fitted nicely to a suitably extended elastic theory. At higher tensions the elastic fit consistently underestimates the strength of long-wavelength fluctuations. Finally, we investigate the influence of tension on the effective interaction between simple transmembrane inclusions and show that tension can be used to tune the hydrophobic mismatch interaction between membrane proteins.
Addresses
  • Department of Physics, University of Konstanz, 78457 Konstanz, Germany. joerg.neder@uni-konstanz.de
Autoren
DOI
10.1063/1.3352583
eISSN
1089-7690
Externe Identifier
  • PubMed Identifier: 20331316
Open access
false
ISSN
0021-9606
Ausgabe der Veröffentlichung
11
Zeitschrift
The Journal of chemical physics
Schlüsselwörter
  • Lipids
  • Lipid Bilayers
  • Monte Carlo Method
  • Temperature
  • Diffusion
  • Surface Tension
  • Pressure
  • Molecular Dynamics Simulation
Sprache
eng
Medium
Print
Paginierung
115101
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Coarse-grained simulations of membranes under tension.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
132

Data source: Europe PubMed Central

Abstract
We investigate the properties of membranes under tension by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers. We give a comprising overview of the behavior of several membrane characteristics, such as the area per lipid, the monolayer overlap, the nematic order, and pressure profiles. Both the low-temperature regime, where the membranes are in a gel L(beta(')) phase, and the high-temperature regime, where they are in the fluid L(alpha) phase, are considered. In the L(beta(')) state, the membrane is hardly influenced by tension. In the fluid state, high tensions lead to structural changes in the membrane, which result in different compressibility regimes. The ripple state P(beta(')), which is found at tension zero in the transition regime between L(alpha) and L(beta(')), disappears under tension and gives way to an interdigitated phase. We also study the membrane fluctuations in the fluid phase. In the low-tension regime the data can be fitted nicely to a suitably extended elastic theory. At higher tensions the elastic fit consistently underestimates the strength of long-wavelength fluctuations. Finally, we investigate the influence of tension on the effective interaction between simple transmembrane inclusions and show that tension can be used to tune the hydrophobic mismatch interaction between membrane proteins.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20331316
DOI
10.1063/1.3352583
eISSN
1089-7690
Ausgabe der Veröffentlichung
11
Zeitschrift
J Chem Phys
Schlüsselwörter
  • Diffusion
  • Lipid Bilayers
  • Lipids
  • Molecular Dynamics Simulation
  • Monte Carlo Method
  • Pressure
  • Surface Tension
  • Temperature
Sprache
eng
Country
United States
Paginierung
115101
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
Coarse-grained simulations of membranes under tension.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
132

Data source: PubMed

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