Natural products in drug discovery: Advances and opportunities
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Atanas G Atanasov
- Sergey B Zotchev
- Verena M Dirsch
- Claudiu T Supuran
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000612711300001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/s41573-020-00114-z
- eISSN
- 1474-1784
- Externe Identifier
- Clarivate Analytics Document Solution ID: QS5SD
- PubMed Identifier: 33510482
- ISSN
- 1474-1776
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- NATURE REVIEWS DRUG DISCOVERY
- Paginierung
- 200 - 216
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Natural products in drug discovery: advances and opportunities
- Sub types
- Review
- Ausgabe der Zeitschrift
- 20
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Atanas G Atanasov
- Sergey B Zotchev
- Verena M Dirsch
- Claudiu T Supuran
- DOI
- 10.1038/s41573-020-00114-z
- eISSN
- 1474-1784
- ISSN
- 1474-1776
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Nature Reviews Drug Discovery
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 200 - 216
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41573-020-00114-z
- Datum der Datenerfassung
- 2023
- Titel
- Natural products in drug discovery: advances and opportunities
- Ausgabe der Zeitschrift
- 20
Data source: Crossref
- Abstract
- Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments - including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances - are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
- Addresses
- Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, Poland. a.atanasov.mailbox@gmail.com.
- Autoren
- Atanas G Atanasov
- Sergey B Zotchev
- Verena M Dirsch
- International Natural Product Sciences Taskforce
- Claudiu T Supuran
- DOI
- 10.1038/s41573-020-00114-z
- eISSN
- 1474-1784
- Externe Identifier
- PubMed Identifier: 33510482
- PubMed Central ID: PMC7841765
- Funding acknowledgements
- Austrian Science Fund FWF: P 32109
- NIA NIH HHS: R01 AG066749
- Medical Research Council: MC_UU_12011/4
- NIA NIH HHS: U24 AG047867
- National Institute for Health Research (NIHR): NIHR200286
- Economic and Social Research Council: ES/M00919X/1
- NIMHD NIH HHS: G12 MD007591
- Biotechnology and Biological Sciences Research Council: BB/L01923X/1
- National Institute for Health Research (NIHR): NF-SI-0515-10042
- Open access
- true
- ISSN
- 1474-1776
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Nature reviews. Drug discovery
- Schlüsselwörter
- International Natural Product Sciences Taskforce
- Humans
- Communicable Diseases
- Neoplasms
- Biological Products
- Genome
- Drug Industry
- Drug Discovery
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2021
- Open access status
- Open Access
- Paginierung
- 200 - 216
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum der Datenerfassung
- 2021
- Titel
- Natural products in drug discovery: advances and opportunities.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 20
Files
https://www.nature.com/articles/s41573-020-00114-z.pdf https://europepmc.org/articles/PMC7841765?pdf=render
Data source: Europe PubMed Central
- Abstract
- Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments - including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances - are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
- Date of acceptance
- 2020
- Autoren
- Atanas G Atanasov
- Sergey B Zotchev
- Verena M Dirsch
- International Natural Product Sciences Taskforce
- Claudiu T Supuran
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33510482
- DOI
- 10.1038/s41573-020-00114-z
- eISSN
- 1474-1784
- Externe Identifier
- PubMed Central ID: PMC7841765
- Funding acknowledgements
- Austrian Science Fund FWF: P 32109
- NIA NIH HHS: U24 AG047867
- NIMHD NIH HHS: G12 MD007591
- Medical Research Council: MC_UU_12011/4
- NIA NIH HHS: R01 AG066749
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Nat Rev Drug Discov
- Schlüsselwörter
- Biological Products
- Communicable Diseases
- Drug Discovery
- Drug Industry
- Genome
- Humans
- Neoplasms
- Sprache
- eng
- Country
- England
- Paginierung
- 200 - 216
- PII
- 10.1038/s41573-020-00114-z
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Natural products in drug discovery: advances and opportunities.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 20
Data source: PubMed
- Autoren
- Atanas G Atanasov
- Sergey B Zotchev
- Verena M Dirsch
- Claudiu T Supuran
- Zeitschrift
- Nature reviews Drug discovery
- Artikelnummer
- 3
- Paginierung
- 200 - 216
- Datum der Veröffentlichung
- 2021
- Datum der Datenerfassung
- 2023
- Titel
- Natural products in drug discovery: Advances and opportunities
- Sub types
- article
- Ausgabe der Zeitschrift
- 20
Data source: Manual
- Beziehungen:
- Property of