Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby

Publication type:
Journal article
Metadata:
Autoren
  • Cui Wang
  • Kenny Ebel
  • Katja Heinze
  • Ute Resch-Genger
  • Ilko Bald
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000950045900001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/chem.202203719
eISSN
1521-3765
Externe Identifier
  • Clarivate Analytics Document Solution ID: ET8O0
  • PubMed Identifier: 36734093
ISSN
0947-6539
Ausgabe der Veröffentlichung
23
Zeitschrift
CHEMISTRY-A EUROPEAN JOURNAL
Schlüsselwörter
  • chromium
  • DNA origami
  • DNA strand breaks
  • photodynamic therapy
  • photosensitizer
Datum der Veröffentlichung
2023
Status
Published
Titel
Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby
Sub types
  • Article
Ausgabe der Zeitschrift
29

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>Photodynamic therapy (PDT) used for treating cancer relies on the generation of highly reactive oxygen species, for example, singlet oxygen<jats:sup>1</jats:sup>O<jats:sub>2</jats:sub>, by light‐induced excitation of a photosensitizer (PS) in the presence of molecular oxygen, inducing DNA damage in close proximity of the PS. Although many precious metal complexes have been explored as PS for PDT and received clinical approval, only recently, the potential of photoactive complexes of non‐noble metals as PS has been discovered. Using the DNA origami technology that can absolutely quantify DNA strand break cross sections, we assessed the potential of the luminescent transition metal complex [Cr(ddpd)<jats:sub>2</jats:sub>]<jats:sup>3+</jats:sup>(ddpd=<jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>′‐dimethyl‐N,N′‐dipyridine‐2‐ylpyridine‐2,6‐diamine) to damage DNA in an air‐saturated aqueous environment upon UV/Vis illumination. The quantum yield for strand breakage, that is, the ratio of DNA strand breaks to the number of absorbed photons, was determined to 1–4 %, indicating efficient transformation of photons into DNA strand breaks by [Cr(ddpd)<jats:sub>2</jats:sub>]<jats:sup>3+</jats:sup>.</jats:p>
Autoren
  • Cui Wang
  • Kenny Ebel
  • Katja Heinze
  • Ute Resch‐Genger
  • Ilko Bald
DOI
10.1002/chem.202203719
eISSN
1521-3765
ISSN
0947-6539
Ausgabe der Veröffentlichung
23
Zeitschrift
Chemistry – A European Journal
Sprache
en
Online publication date
2023
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/chem.202203719
Datum der Datenerfassung
2023
Titel
Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby
Ausgabe der Zeitschrift
29

Data source: Crossref

Abstract
Photodynamic therapy (PDT) used for treating cancer relies on the generation of highly reactive oxygen species, for example, singlet oxygen <sup>1</sup> O<sub>2</sub> , by light-induced excitation of a photosensitizer (PS) in the presence of molecular oxygen, inducing DNA damage in close proximity of the PS. Although many precious metal complexes have been explored as PS for PDT and received clinical approval, only recently, the potential of photoactive complexes of non-noble metals as PS has been discovered. Using the DNA origami technology that can absolutely quantify DNA strand break cross sections, we assessed the potential of the luminescent transition metal complex [Cr(ddpd)<sub>2</sub> ]<sup>3+</sup> (ddpd=N,N'-dimethyl-N,N'-dipyridine-2-ylpyridine-2,6-diamine) to damage DNA in an air-saturated aqueous environment upon UV/Vis illumination. The quantum yield for strand breakage, that is, the ratio of DNA strand breaks to the number of absorbed photons, was determined to 1-4 %, indicating efficient transformation of photons into DNA strand breaks by [Cr(ddpd)<sub>2</sub> ]<sup>3+</sup> .
Addresses
  • Division Biophotonics, Federal Institute for Materials Research and Testing (BAM), Richard-Willstaetter Strasse 11, 12489, Berlin, Germany.
Autoren
  • Cui Wang
  • Kenny Ebel
  • Katja Heinze
  • Ute Resch-Genger
  • Ilko Bald
DOI
10.1002/chem.202203719
eISSN
1521-3765
Externe Identifier
  • PubMed Identifier: 36734093
Funding acknowledgements
  • European Research Council: 772752
  • Deutsche Forschungsgemeinschaft: RE 1203/23-2
  • Deutsche Forschungsgemeinschaft: HE 2778/10-2
Open access
false
ISSN
0947-6539
Ausgabe der Veröffentlichung
23
Zeitschrift
Chemistry (Weinheim an der Bergstrasse, Germany)
Schlüsselwörter
  • DNA Damage
  • Reactive Oxygen Species
  • Phenylenediamines
  • DNA
  • Photosensitizing Agents
Sprache
eng
Medium
Print-Electronic
Online publication date
2023
Paginierung
e202203719
Datum der Veröffentlichung
2023
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2023
Titel
Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
29

Data source: Europe PubMed Central

Abstract
Photodynamic therapy (PDT) used for treating cancer relies on the generation of highly reactive oxygen species, for example, singlet oxygen 1 O2 , by light-induced excitation of a photosensitizer (PS) in the presence of molecular oxygen, inducing DNA damage in close proximity of the PS. Although many precious metal complexes have been explored as PS for PDT and received clinical approval, only recently, the potential of photoactive complexes of non-noble metals as PS has been discovered. Using the DNA origami technology that can absolutely quantify DNA strand break cross sections, we assessed the potential of the luminescent transition metal complex [Cr(ddpd)2 ]3+ (ddpd=N,N'-dimethyl-N,N'-dipyridine-2-ylpyridine-2,6-diamine) to damage DNA in an air-saturated aqueous environment upon UV/Vis illumination. The quantum yield for strand breakage, that is, the ratio of DNA strand breaks to the number of absorbed photons, was determined to 1-4 %, indicating efficient transformation of photons into DNA strand breaks by [Cr(ddpd)2 ]3+ .
Autoren
  • Cui Wang
  • Kenny Ebel
  • Katja Heinze
  • Ute Resch-Genger
  • Ilko Bald
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/36734093
DOI
10.1002/chem.202203719
eISSN
1521-3765
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: RE 1203/23-2
  • Deutsche Forschungsgemeinschaft: HE 2778/10-2
  • H2020 European Research Council: 772752
Ausgabe der Veröffentlichung
23
Zeitschrift
Chemistry
Schlüsselwörter
  • DNA origami
  • DNA strand breaks
  • chromium
  • photodynamic therapy
  • photosensitizer
  • DNA
  • Phenylenediamines
  • DNA Damage
  • Reactive Oxygen Species
  • Photosensitizing Agents
Sprache
eng
Country
Germany
Paginierung
e202203719
Datum der Veröffentlichung
2023
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Titel
Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
29

Data source: PubMed

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