The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Platelet indices have been associated with traditional cardiovascular risk factors, cardiovascular diseases and all‐cause mortality. This study aimed to investigate the role of platelet count, mean platelet volume (MPV) and platelet‐to‐leukocyte ratio, including platelet‐to‐monocyte and platelet‐to‐lymphocyte ratio with cardiac function, heart failure (HF) phenotypes and clinical outcome, worsening of HF.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Univariate and multivariable linear and Cox regression analyses were used to investigate the associations between platelet indices, cardiac function and worsening of HF in 3250 subjects enrolled in the MyoVasc study. Higher MPV, lower platelet count, lower platelet‐to‐leukocyte and platelet‐to‐monocyte ratios have been associated with reduced left ventricular ejection fraction (beta estimate [β]<jats:sub>MPV [fL]</jats:sub> = −0.05 [−0.09; −0.02], β<jats:sub>platelet count (× 10</jats:sub><jats:sub>/L)</jats:sub><jats:sup>9</jats:sup> = 3.4 [1.2; 5.6], β<jats:sub>platelet‐to‐leukocyte ratio</jats:sub> = 1.4 [1.1; 1.8], β<jats:sub>platelet‐to‐monocyte ratio</jats:sub> = 28 [20; 36]) and increased E/E' ratio (β <jats:sub>MPV [fL]</jats:sub> = 0.04 [0.003; 0.07], β<jats:sub>platelet count (× 10</jats:sub><jats:sub>/L)</jats:sub><jats:sup>9</jats:sup> = −3.1 [−5.3; −0.92], β<jats:sub>platelet‐to‐leukocyte ratio</jats:sub> = −0.83 [−1.2; −0.46], β<jats:sub>platelet‐to‐monocyte ratio</jats:sub> = −20 [−28; −12]), independent of age and sex. Cox regression demonstrated an increased risk for worsening of HF in subjects with MPV &gt; 75th percentile (hazard ratio [HR] = 1.47 [1.16; 1.87]), platelet count &lt; 25th percentile (HR = 1.36 [1.07; 1.74]), platelet‐to‐leukocyte &lt; 25th percentile (HR = 1.53 [1.20; 1.95]), platelet‐to‐monocyte &lt; 25th percentile (HR = 1.38 [1.08; 1.77]) and platelet‐to‐lymphocyte &gt; 75th percentile (HR = 1.50 [1.17; 1.93]) ratios, independent of potential confounders. MPV &gt; 75th percentile and platelet count &lt; 25th percentile were strongly related to outcome in HFpEF vs. HFrEF (<jats:italic>P</jats:italic> for difference = 0.040). Platelet‐to‐leukocyte ratios were associated with worse outcome in both HF phenotypes, without a significant difference between HFpEF and HFrEF.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Platelet indices are linked with worse cardiac function and adverse clinical outcome, independent of subjects' underlying cardiovascular profile. This study emphasizes their important value to provide additional information on pathophysiology and risk stratification in HF syndrome.</jats:p></jats:sec>
Autoren
  • Bianca Dahlen
  • Andreas Schulz
  • Sebastian Göbel
  • Sven‐Oliver Tröbs
  • Sören Schwuchow‐Thonke
  • Henri M Spronk
  • Jürgen H Prochaska
  • Natalie Arnold
  • Karl J Lackner
  • Tommaso Gori
  • Hugo ten Cate
  • Thomas Münzel
  • Philipp S Wild
  • Marina Panova‐Noeva
DOI
10.1002/ehf2.13390
eISSN
2055-5822
ISSN
2055-5822
Ausgabe der Veröffentlichung
4
Zeitschrift
ESC Heart Failure
Sprache
en
Online publication date
2021
Paginierung
2991 - 3001
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/ehf2.13390
Datum der Datenerfassung
2023
Titel
The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study
Ausgabe der Zeitschrift
8

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY-NC-ND
Autoren
  • Bianca Dahlen
  • Andreas Schulz
  • Sebastian Göbel
  • Sven-Oliver Tröbs
  • Sören Schwuchow-Thonke
  • Henri M Spronk
  • Jürgen H Prochaska
  • Natalie Arnold
  • Karl Lackner
  • Tommaso Gori
  • Hugo ten Cate
  • Thomas Münzel
  • Philipp S Wild
  • Marina Panova-Noeva
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1002/ehf2.13390
File(s) embargoed
false
Open access
true
ISSN
2055-5822
Ausgabe der Veröffentlichung
4
Zeitschrift
ESC heart failure
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
2991 - 3001
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8892
Herausgeber
Wiley
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
The impact of platelet indices on clinical outcome in heart failure : results from the MyoVasc study
Ausgabe der Zeitschrift
8

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the_impact_of_platelet_indice-20230303104946620.pdf

Data source: OPENSCIENCE.UB

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