Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 x Tg-AD transgenic mice

Publication type:
Journal article
Metadata:
Autoren
  • Zhiwei Xu
  • Xiaojie Zhou
  • Xiao Hong
  • Sichen Wang
  • Jiale Wei
  • Junhao Huang
  • Liting Ji
  • Yuanxiao Yang
  • Thomas Efferth
  • Chunlan Hong
  • Changyu Li
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000944257200001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2023.154695
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 9P4LM
  • PubMed Identifier: 36774844
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Acorus tatarinowii
  • Alzheimer's disease
  • Neuroinflammation
  • NLRP3 inflammasome
  • Phytotherapy
Artikelnummer
ARTN 154695
Datum der Veröffentlichung
2023
Status
Published
Titel
Essential oil of <i>Acorus tatarinowii</i> Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 x Tg-AD transgenic mice
Sub types
  • Article
Ausgabe der Zeitschrift
112

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Zhiwei Xu
  • Xiaojie Zhou
  • Xiao Hong
  • Sichen Wang
  • Jiale Wei
  • Junhao Huang
  • Liting Ji
  • Yuanxiao Yang
  • Thomas Efferth
  • Chunlan Hong
  • Changyu Li
DOI
10.1016/j.phymed.2023.154695
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
154695
Paginierung
154695 - 154695
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2023.154695
Datum der Datenerfassung
2024
Titel
Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice
Ausgabe der Zeitschrift
112

Data source: Crossref

Abstract
<h4>Background</h4>Shi chang pu (Acorus tatarinowii Schott) is a herbal used in the treatment of Alzheimer's disease (AD) in China. The essential oil of Shi chang pu (SCP-oil) is the main active component. However, its effects on the neuroinflammation of AD have not been well studied.<h4>Purpose</h4>Neuroinflammation mediated by the NLRP3 inflammasome plays a crucial role in AD. This study was designed to evaluate the effect of SCP-oil on cognitive impairment of App<sub>Swe</sub>/PSEN1<sub>M146V</sub>/MAPT<sub>P301L</sub> triple transgenic (3 × Tg-AD) mice model and investigate the mechanism underlying its anti-inflammation effects.<h4>Methods</h4>Thirty-two 3 × Tg-AD mice at 12 months and 8 wild-type B6 mice were used for this experiment. The 3 × Tg-AD mice were administered with SCP-oil or donepezil hydrochloride for 8 weeks. Morris water maze test and step-down test were used to evaluate the cognitive ability of mice. The pathological changes, neuroinflammation, and the NLRP3 inflammasome related-protein of AD mice were detected by histomorphological examination, TUNEL staining, immunofluorescence, immunohistochemistry, qRT-PCR, Elisa, and western blot assays.<h4>Results</h4>SCP-oil treatment attenuated cognitive dysfunction of 3 × Tg-AD mice. Moreover, SCP-oil also ameliorated characteristics pathological of AD, such as pathological changes damage, deposition of Aβ, phosphorylation of Tau, and neuronal loss. Additionally, SCP-oil treatment alleviated the neuroinflammation and inhibited phosphorylation of IKKβ, NF-κB, and NLRP3 inflammasome related-protein NLRP3, ASC, Caspase-1, cleaved-Caspase-1, and GSDMD-N in the hippocampus of 3 × Tg-AD mice.<h4>Conclusion</h4>Overall, SCP-oil contributed to neuroprotection in 3 × Tg-AD mice by reduced activation of NLRP3 inflammasome by inhibiting the NF-κB signaling pathway.
Addresses
  • School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Autoren
  • Zhiwei Xu
  • Xiaojie Zhou
  • Xiao Hong
  • Sichen Wang
  • Jiale Wei
  • Junhao Huang
  • Liting Ji
  • Yuanxiao Yang
  • Thomas Efferth
  • Chunlan Hong
  • Changyu Li
DOI
10.1016/j.phymed.2023.154695
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 36774844
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Animals
  • Mice, Transgenic
  • Mice
  • Acorus
  • Alzheimer Disease
  • Caspase 1
  • Oils, Volatile
  • NF-kappa B
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Neuroinflammatory Diseases
Sprache
eng
Medium
Print-Electronic
Online publication date
2023
Paginierung
154695
Datum der Veröffentlichung
2023
Status
Published
Datum der Datenerfassung
2023
Titel
Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
112

Data source: Europe PubMed Central

Abstract
BACKGROUND: Shi chang pu (Acorus tatarinowii Schott) is a herbal used in the treatment of Alzheimer's disease (AD) in China. The essential oil of Shi chang pu (SCP-oil) is the main active component. However, its effects on the neuroinflammation of AD have not been well studied. PURPOSE: Neuroinflammation mediated by the NLRP3 inflammasome plays a crucial role in AD. This study was designed to evaluate the effect of SCP-oil on cognitive impairment of AppSwe/PSEN1M146V/MAPTP301L triple transgenic (3 × Tg-AD) mice model and investigate the mechanism underlying its anti-inflammation effects. METHODS: Thirty-two 3 × Tg-AD mice at 12 months and 8 wild-type B6 mice were used for this experiment. The 3 × Tg-AD mice were administered with SCP-oil or donepezil hydrochloride for 8 weeks. Morris water maze test and step-down test were used to evaluate the cognitive ability of mice. The pathological changes, neuroinflammation, and the NLRP3 inflammasome related-protein of AD mice were detected by histomorphological examination, TUNEL staining, immunofluorescence, immunohistochemistry, qRT-PCR, Elisa, and western blot assays. RESULTS: SCP-oil treatment attenuated cognitive dysfunction of 3 × Tg-AD mice. Moreover, SCP-oil also ameliorated characteristics pathological of AD, such as pathological changes damage, deposition of Aβ, phosphorylation of Tau, and neuronal loss. Additionally, SCP-oil treatment alleviated the neuroinflammation and inhibited phosphorylation of IKKβ, NF-κB, and NLRP3 inflammasome related-protein NLRP3, ASC, Caspase-1, cleaved-Caspase-1, and GSDMD-N in the hippocampus of 3 × Tg-AD mice. CONCLUSION: Overall, SCP-oil contributed to neuroprotection in 3 × Tg-AD mice by reduced activation of NLRP3 inflammasome by inhibiting the NF-κB signaling pathway.
Date of acceptance
2023
Autoren
  • Zhiwei Xu
  • Xiaojie Zhou
  • Xiao Hong
  • Sichen Wang
  • Jiale Wei
  • Junhao Huang
  • Liting Ji
  • Yuanxiao Yang
  • Thomas Efferth
  • Chunlan Hong
  • Changyu Li
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/36774844
DOI
10.1016/j.phymed.2023.154695
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Acorus tatarinowii
  • Alzheimer's disease
  • NLRP3 inflammasome
  • Neuroinflammation
  • Phytotherapy
  • Mice
  • Animals
  • Inflammasomes
  • Alzheimer Disease
  • Mice, Transgenic
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Acorus
  • NF-kappa B
  • Neuroinflammatory Diseases
  • Oils, Volatile
  • Caspase 1
Sprache
eng
Country
Germany
Paginierung
154695
PII
S0944-7113(23)00055-7
Datum der Veröffentlichung
2023
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Titel
Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
112

Data source: PubMed

Beziehungen:
Property of

Tools