Bio- inspired temporal regulation of ion- transport in nanochannels
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- KP Sonu
- Sushmitha Vinikumar
- Shikha Dhiman
- Subi J George
- Muthusamy Eswaramoorthy
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000477090200024&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1039/c8na00414e
- Externe Identifier
- Clarivate Analytics Document Solution ID: IL1VK
- PubMed Identifier: 36134245
- ISSN
- 2516-0230
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- NANOSCALE ADVANCES
- Paginierung
- 1847 - 1852
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- Bio- inspired temporal regulation of ion- transport in nanochannels
- Sub types
- Article
- Ausgabe der Zeitschrift
- 1
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <p>Mesoporous silica showing pH responsive gating was coupled with an enzymatic reaction to achieve the temporal regulation of ion transport.</p>
- Autoren
- KP Sonu
- Sushmitha Vinikumar
- Shikha Dhiman
- Subi J George
- Muthusamy Eswaramoorthy
- DOI
- 10.1039/c8na00414e
- eISSN
- 2516-0230
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nanoscale Advances
- Sprache
- en
- Online publication date
- 2019
- Paginierung
- 1847 - 1852
- Status
- Published online
- Herausgeber
- Royal Society of Chemistry (RSC)
- Herausgeber URL
- http://dx.doi.org/10.1039/c8na00414e
- Datum der Datenerfassung
- 2024
- Titel
- Bio-inspired temporal regulation of ion-transport in nanochannels
- Ausgabe der Zeitschrift
- 1
Data source: Crossref
- Abstract
- Temporal regulation of mass transport across the membrane is a vital feature of biological systems. Such regulatory mechanisms rely on complex biochemical reaction networks, often operating far from equilibrium. Herein, we demonstrate biochemical reaction mediated temporal regulation of mass transport in nanochannels of mesoporous silica sphere. The rationally designed nanochannels with pH responsive electrostatic gating are fabricated through a hetero-functionalization approach utilizing propylamine and carboxylic acid moieties. At basic pH, cationic small molecules can diffuse into the nanochannels which release back to the solution at acidic pH. The transient ion transport is temporally controlled using a base as fuel along with esterase enzyme as the mediator. The slow enzymatic hydrolysis of a dormant deactivator (ethyl acetate) determines the lifetime of transient encapsulated state, which can be programmed easily by modulating the enzymatic activity of esterase. This system represents a unique approach to create autonomous artificial cellular models.
- Addresses
- Nanomaterials and Catalysis Laboratory, Chemistry and Physics of Materials Unit, School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research Jakkur P.O. Bangalore 560064 India eswar@jncasr.ac.in.
- Autoren
- KP Sonu
- Sushmitha Vinikumar
- Shikha Dhiman
- Subi J George
- Muthusamy Eswaramoorthy
- DOI
- 10.1039/c8na00414e
- eISSN
- 2516-0230
- Externe Identifier
- PubMed Identifier: 36134245
- PubMed Central ID: PMC9418411
- Funding acknowledgements
- Jawaharlal Nehru Centre for Advanced Scientific Research:
- Sheikh Saqr Laboratory:
- Open access
- true
- ISSN
- 2516-0230
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nanoscale advances
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2019
- Open access status
- Open Access
- Paginierung
- 1847 - 1852
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Bio-inspired temporal regulation of ion-transport in nanochannels.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 1
Files
https://pubs.rsc.org/en/content/articlepdf/2019/na/c8na00414e https://europepmc.org/articles/PMC9418411?pdf=render
Data source: Europe PubMed Central
- Abstract
- Temporal regulation of mass transport across the membrane is a vital feature of biological systems. Such regulatory mechanisms rely on complex biochemical reaction networks, often operating far from equilibrium. Herein, we demonstrate biochemical reaction mediated temporal regulation of mass transport in nanochannels of mesoporous silica sphere. The rationally designed nanochannels with pH responsive electrostatic gating are fabricated through a hetero-functionalization approach utilizing propylamine and carboxylic acid moieties. At basic pH, cationic small molecules can diffuse into the nanochannels which release back to the solution at acidic pH. The transient ion transport is temporally controlled using a base as fuel along with esterase enzyme as the mediator. The slow enzymatic hydrolysis of a dormant deactivator (ethyl acetate) determines the lifetime of transient encapsulated state, which can be programmed easily by modulating the enzymatic activity of esterase. This system represents a unique approach to create autonomous artificial cellular models.
- Date of acceptance
- 2019
- Autoren
- KP Sonu
- Sushmitha Vinikumar
- Shikha Dhiman
- Subi J George
- Muthusamy Eswaramoorthy
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36134245
- DOI
- 10.1039/c8na00414e
- eISSN
- 2516-0230
- Externe Identifier
- PubMed Central ID: PMC9418411
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nanoscale Adv
- Sprache
- eng
- Country
- England
- Paginierung
- 1847 - 1852
- PII
- c8na00414e
- Datum der Veröffentlichung
- 2019
- Status
- Published online
- Titel
- Bio-inspired temporal regulation of ion-transport in nanochannels.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 1
Data source: PubMed
- Beziehungen:
-