Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Cigarette smoking is a threat to global human health and a leading cause of the cardiovascular disease (CVD) morbidity and mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key event in the development of atherosclerotic CVD, remain still elusive. Thus, this study sought out to investigate sex-specific associations between smoking and measures of arterial stiffness.</jats:p> </jats:sec><jats:sec> <jats:title>Methods and results</jats:title> <jats:p>Overall, 15,010 participants (7584 men and 7426 women aged 35–74 years) of the Gutenberg Health Study were examined at baseline during 2007–2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a standardized computer-assisted interview. Arterial stiffness and wave reflection were determined by stiffness index (SI) and augmentation index (AI). In the total sample, 45.8% had never smoked, 34.7% were former smokers, and 19.4% were current smokers. Median cumulative smoking exposure was 22.0 pack-years in current male smokers and 16.0 in current female smokers. In general, multivariable linear regression models adjusted for a comprehensive set of confounders revealed that smoking status, pack-years of smoking, and years since quitting smoking were dose-dependently associated with markers of arterial stiffness. In sex-specific analyses, these associations were overall more pronounced in men and SI was stronger related to the male sex, whereas differences between men and women in the case of AI appeared to be less substantial.</jats:p> </jats:sec><jats:sec> <jats:title>Discussion</jats:title> <jats:p>The present results indicate that chronic smoking is strongly and dose-dependently associated with increased arterial stiffness in a large population-based cohort regardless of sex but with a stronger association in men.</jats:p> </jats:sec>
Autoren
  • Omar Hahad
  • Volker H Schmitt
  • Natalie Arnold
  • Karsten Keller
  • Jürgen H Prochaska
  • Philipp S Wild
  • Andreas Schulz
  • Karl J Lackner
  • Norbert Pfeiffer
  • Irene Schmidtmann
  • Matthias Michal
  • Jörn M Schattenberg
  • Oliver Tüscher
  • Andreas Daiber
  • Thomas Münzel
DOI
10.1007/s00392-022-02092-1
eISSN
1861-0692
ISSN
1861-0684
Ausgabe der Veröffentlichung
2
Zeitschrift
Clinical Research in Cardiology
Sprache
en
Online publication date
2022
Paginierung
270 - 284
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00392-022-02092-1
Datum der Datenerfassung
2023
Titel
Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort
Ausgabe der Zeitschrift
112

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Omar Hahad
  • Volker H Schmitt
  • Natalie Arnold
  • Karsten Keller
  • Jürgen H Prochaska
  • Philipp S Wild
  • Karl J Lackner
  • Norbert Pfeiffer
  • Irene Schmidtmann
  • Matthias Michal
  • Jörn M Schattenberg
  • Oliver Tüscher
  • Andreas Daiber
  • Thomas Münzel
  • Andreas Schulz
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-H
Resource version
Published version
DOI
10.1007/s00392-022-02092-1
Funding acknowledgements
  • Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577
File(s) embargoed
false
Open access
true
ISSN
1861-0692
Zeitschrift
Clinical research in cardiology
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8408
Herausgeber
Springer
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Chronic cigarette smoking is associated with increased arterial stiffness in men and women : evidence from a large population-based cohort
Ausgabe der Zeitschrift
Version of Record (VoR)

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chronic_cigarette_smoking_is_-20221124121218581.pdf

Data source: OPENSCIENCE.UB

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