Refractive error, accommodation and lens opacification in adults born preterm and full‐term: Results from the Gutenberg Prematurity Eye Study (GPES)

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>To evaluate the long‐term effects of different degrees of prematurity, retinopathy of prematurity (ROP) and associated perinatal factors on refractive error, accommodation and lens opacification development in adults born preterm aged 18–52 years.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The Gutenberg Prematurity Eye Study (GPES) investigated adults born preterm and full‐term at 18–52 years in Germany to assess refractive error, accommodation amplitude and lens opacification. The participants were grouped into normal gestational age (GA) ≥37 weeks (control group), preterm participants without ROP and GA 33–36 weeks (group 2), GA 29–32 weeks (group 3), GA ≤28 weeks (group 4) and those with ROP without (group 5) or with treatment (group 6). Main outcome measures were refractive error, anisometropia, accommodation amplitude and lens opacification.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In total, 856 eyes of 433 preterm and full‐term individuals (aged 28.4 +/− 8.6 years, 242 females) were included. A myopic refractive error of &gt;6 diopter was observed in 4% (11/278), 2.7% (7/264), 1.2% (2/174), 5.6% (2/36), 10.5% (8/78) and 26.9% (7/26) of eyes and anisometropia ≥2 diopter in 2.9% (4/139), 2.3% (3/132), 3.5% (3/87), 11.1% (2/18), 9.5% (4/44) and 38.5% (5/13) of participants in the respective groups. Spherical equivalent did not differ between participants without postnatal ROP born moderately, very and extremely preterm compared to the full‐term control group. ROP treatment was associated with lower accommodation and more lens opacifications.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Retinopathy of prematurity treatment using cryocoagulation and laser coagulation increases refractive error associated with increased lens opacifications and reduced accommodation. Preterm delivery has little effect on absolute refractive error but is associated with anisometropia in adulthood.</jats:p></jats:sec>
Autoren
  • Achim Fieß
  • Agnes Fauer
  • Eva Mildenberger
  • Michael S Urschitz
  • Heike M Elflein
  • Fred Zepp
  • Bernhard Stoffelns
  • Norbert Pfeiffer
  • Alexander K Schuster
DOI
10.1111/aos.15116
eISSN
1755-3768
ISSN
1755-375X
Ausgabe der Veröffentlichung
7
Zeitschrift
Acta Ophthalmologica
Sprache
en
Online publication date
2022
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/aos.15116
Datum der Datenerfassung
2023
Titel
Refractive error, accommodation and lens opacification in adults born preterm and full‐term: Results from the Gutenberg Prematurity Eye Study (<scp>GPES</scp>)
Ausgabe der Zeitschrift
100

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY-NC
Autoren
  • Achim Fieß
  • Agnes Fauer
  • Eva Mildenberger
  • Michael S Urschitz
  • Heike Elflein
  • Fred Zepp
  • Bernahrd Stoffelns
  • Norbert Pfeiffer
  • Alexander K Schuster
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-H
Resource version
Published version
DOI
10.1111/aos.15116
Funding acknowledgements
  • Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577
File(s) embargoed
false
Open access
true
ISSN
1755-3768
Ausgabe der Veröffentlichung
7
Zeitschrift
Acta ophthalmologica
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
e1439 - e1450
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8636
Herausgeber
Blackwell
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Refractive error, accommodation and lens opacification in adults born preterm and full-term : results from the Gutenberg Prematurity Eye Study (GPES)
Ausgabe der Zeitschrift
100

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refractive_error_accommodatio-20230120124425643.pdf

Data source: OPENSCIENCE.UB

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