Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Maria Letizia Di Pietro
- Claudio Stagno
- Thomas Efferth
- Ejlal A Omer
- Valeria D'Angelo
- Maria Paola Germano
- Anna Cacciola
- Federica De Gaetano
- Nunzio Iraci
- Nicola Micale
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000903476300001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/molecules27249000
- eISSN
- 1420-3049
- Externe Identifier
- Clarivate Analytics Document Solution ID: 7H8VW
- PubMed Identifier: 36558133
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- MOLECULES
- Schlüsselwörter
- platinum(II)-based complexes
- anticancer agents
- leukemia cell lines
- CAM assay
- molecular modeling studies
- Artikelnummer
- ARTN 9000
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes
- Sub types
- Article
- Ausgabe der Zeitschrift
- 27
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, LDP-1–4, synthesized and characterized according to previously reported procedures. Molecular-modelling studies highlighted that the top two LDP compounds (i.e., LDP-1 and LDP-4) might bind to both matched and mismatched base pair sites of the oligonucleotide 5′-(dCGGAAATTACCG)2-3′, supporting their anticancer potential. These two complexes displayed noteworthy cytotoxicity in vitro (sub-micromolar–micromolar range) against two leukaemia cell lines, i.e., CCRF-CEM and its multi-drug-resistant counterpart CEM/ADR5000, and remarkable anti-angiogenic properties (in the sub-micromolar range) evaluated in an in vivo model, i.e., a chick embryo chorioallantoic membrane (CAM) assay.</jats:p>
- Autoren
- Maria Letizia Di Pietro
- Claudio Stagno
- Thomas Efferth
- Ejlal A Omer
- Valeria D’Angelo
- Maria Paola Germanò
- Anna Cacciola
- Federica De Gaetano
- Nunzio Iraci
- Nicola Micale
- DOI
- 10.3390/molecules27249000
- eISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Molecules
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 9000 - 9000
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/molecules27249000
- Datum der Datenerfassung
- 2022
- Titel
- Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes
- Ausgabe der Zeitschrift
- 27
Data source: Crossref
- Abstract
- Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, <b>LDP-1-4</b>, synthesized and characterized according to previously reported procedures. Molecular-modelling studies highlighted that the top two <b>LDP</b> compounds (i.e., <b>LDP-1</b> and <b>LDP-4</b>) might bind to both matched and mismatched base pair sites of the oligonucleotide 5'-(dCGGAAATTACCG)<sub>2</sub>-3', supporting their anticancer potential. These two complexes displayed noteworthy cytotoxicity in vitro (sub-micromolar-micromolar range) against two leukaemia cell lines, i.e., CCRF-CEM and its multi-drug-resistant counterpart CEM/ADR5000, and remarkable anti-angiogenic properties (in the sub-micromolar range) evaluated in an in vivo model, i.e., a chick embryo chorioallantoic membrane (CAM) assay.
- Addresses
- Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
- Autoren
- Maria Letizia Di Pietro
- Claudio Stagno
- Thomas Efferth
- Ejlal A Omer
- Valeria D'Angelo
- Maria Paola Germanò
- Anna Cacciola
- Federica De Gaetano
- Nunzio Iraci
- Nicola Micale
- DOI
- 10.3390/molecules27249000
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Identifier: 36558133
- PubMed Central ID: PMC9786739
- Open access
- true
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Molecules (Basel, Switzerland)
- Schlüsselwörter
- Cell Line, Tumor
- Chick Embryo
- Animals
- Cisplatin
- Platinum
- DNA
- Antineoplastic Agents
- Coordination Complexes
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 9000
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 27
Files
https://www.mdpi.com/1420-3049/27/24/9000/pdf?version=1671681431 https://europepmc.org/articles/PMC9786739?pdf=render
Data source: Europe PubMed Central
- Abstract
- Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, LDP-1-4, synthesized and characterized according to previously reported procedures. Molecular-modelling studies highlighted that the top two LDP compounds (i.e., LDP-1 and LDP-4) might bind to both matched and mismatched base pair sites of the oligonucleotide 5'-(dCGGAAATTACCG)2-3', supporting their anticancer potential. These two complexes displayed noteworthy cytotoxicity in vitro (sub-micromolar-micromolar range) against two leukaemia cell lines, i.e., CCRF-CEM and its multi-drug-resistant counterpart CEM/ADR5000, and remarkable anti-angiogenic properties (in the sub-micromolar range) evaluated in an in vivo model, i.e., a chick embryo chorioallantoic membrane (CAM) assay.
- Date of acceptance
- 2022
- Autoren
- Maria Letizia Di Pietro
- Claudio Stagno
- Thomas Efferth
- Ejlal A Omer
- Valeria D'Angelo
- Maria Paola Germanò
- Anna Cacciola
- Federica De Gaetano
- Nunzio Iraci
- Nicola Micale
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36558133
- DOI
- 10.3390/molecules27249000
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Central ID: PMC9786739
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Molecules
- Schlüsselwörter
- CAM assay
- anticancer agents
- leukemia cell lines
- molecular modeling studies
- platinum(II)-based complexes
- Animals
- Chick Embryo
- Platinum
- Antineoplastic Agents
- Coordination Complexes
- Cisplatin
- DNA
- Cell Line, Tumor
- Sprache
- eng
- Country
- Switzerland
- PII
- molecules27249000
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 27
Data source: PubMed
- Beziehungen:
- Property of