Dry Eye Parameters and Lid Geometry in Adults Born Extremely, Very, and Moderately Preterm with and without ROP: Results from the Gutenberg Prematurity Eye Study

Publication type:
Journal article
Metadata:
Abstract
<jats:p>Background/Aims: This study aimed to analyze the effects of perinatal history on tear film properties and lid geometry in adults born preterm. Methods: The Gutenberg Prematurity Eye Study (GPES) is a German prospective examination of adults born preterm and term aged 18 to 52 years with Keratograph® 5M and Schirmer test I. Main outcome measures were first non-invasive tear film break-up time (F-NITBUT), bulbar redness (BR), Schirmer test, and nasal palpebral angle measurement. The associations with gestational age (GA), birth weight (BW), and BW percentile, retinopathy of prematurity (ROP), ROP treatment, and other perinatal factors were evaluated using regression analyses. Results: 489 eyes of 255 preterm and 277 eyes of 139 full-term individuals (aged 28.6 +/− 8.8 years, 220 females) were included. Of these, 33 participants (56 eyes) had a history of spontaneously regressed ROP and 9 participants (16 eyes) had a history of ROP treatment. After adjustment for age and sex, lower F-NITBUT (&lt;20 s) was associated with ROP treatment (OR = 4.42; p = 0.025). Lower GA correlated with increased bulbar redness (B = −0.02; p = 0.011) and increased length of wetting in the Schirmer test (B = −0.69; p = 0.003). Furthermore, low GA was associated with narrowing of the nasal palpebral angle (B = 0.22; p = 0.011) adjusted for age and sex, but not when considering ROP in the multivariable model. Conclusion: Our analyses indicate that perinatal history affects ocular surface properties, tear production and lid geometry in adults born term and preterm. This might indicate that affected persons have a predisposition to diseases of the corneal surface such as the dry eye disease.</jats:p>
Autoren
  • Achim Fieß
  • Clara Hufschmidt-Merizian
  • Sandra Gißler
  • Ulrike Hampel
  • Eva Mildenberger
  • Michael S Urschitz
  • Fred Zepp
  • Bernhard Stoffelns
  • Norbert Pfeiffer
  • Alexander K Schuster
DOI
10.3390/jcm11102702
eISSN
2077-0383
Ausgabe der Veröffentlichung
10
Zeitschrift
Journal of Clinical Medicine
Sprache
en
Online publication date
2022
Paginierung
2702 - 2702
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/jcm11102702
Datum der Datenerfassung
2022
Titel
Dry Eye Parameters and Lid Geometry in Adults Born Extremely, Very, and Moderately Preterm with and without ROP: Results from the Gutenberg Prematurity Eye Study
Ausgabe der Zeitschrift
11

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Achim Fieß
  • Clara Hufschmidt-Merizian
  • Sandra Gißler
  • Ulrike Hampel
  • Eva Mildenberger
  • Michael S Urschitz
  • Fred Zepp
  • Bernhard Stoffelns
  • Norbert Pfeiffer
  • Alexander K Schuster
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.3390/jcm11102702
Funding acknowledgements
  • Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577
File(s) embargoed
false
Open access
true
ISSN
2077-0383
Ausgabe der Veröffentlichung
10
Zeitschrift
Journal of Clinical Medicine
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
2702
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7047
Herausgeber
MDPI
Herausgeber URL
https://doi.org/10.3390/jcm11102702
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Dry eye parameters and lid geometry in adults born extremely, very, and moderately preterm with and without ROP : results from the Gutenberg Prematurity Eye Study
Ausgabe der Zeitschrift
11

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dry_eye_parameters_and_lid_ge-20220524114138644.pdf

Data source: OPENSCIENCE.UB

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