Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000882100700001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/ph15111345
eISSN
1424-8247
Externe Identifier
  • Clarivate Analytics Document Solution ID: 6C6CV
  • PubMed Identifier: 36355517
Ausgabe der Veröffentlichung
11
Zeitschrift
PHARMACEUTICALS
Schlüsselwörter
  • red ginseng
  • red sage/danshen
  • gene expression
  • IPA pathways
  • network pharmacology
  • transcriptomics
  • cancer
Artikelnummer
ARTN 1345
Datum der Veröffentlichung
2022
Status
Published
Titel
Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics
Sub types
  • Article
Ausgabe der Zeitschrift
15

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p>Background: This study aimed to assess the effect of a fixed combination of Red Ginseng and Red Sage (RG–RS) on the gene expression of neuronal cells to evaluate the potential impacts on cellular functions and predict its relevance in the treatment of stress and aging-related diseases and disorders. Methods: Gene expression profiling was conducted by transcriptome-wide mRNA microarray analyses of murine HT22 hippocampal cell culture after treatment with RG–RS preparation. Ingenuity pathway analysis (IPA) was performed with datasets of significantly upregulated or downregulated genes and the expected effects on the physiological and cellular function and the diseases were identified. Results: RG–RS deregulates 1028 genes associated with cancer and 139 with metastasis, suggesting a predicted decrease in tumorigenesis, the proliferation of tumor cells, tumor growth, metastasis, and an increase in apoptosis and autophagy by their effects on the various signaling and metabolic pathways, including the inhibition of Warburg’s aerobic glycolysis, estrogen-mediated S-phase entry signaling, osteoarthritis signaling, and the super-pathway of cholesterol biosynthesis. Conclusion: The results of this study provide evidence of the potential efficacy of the fixed combination of Red Ginseng (Panax ginseng C.A. Mey.) and Red Sage/Danshen (Salvia miltiorrhiza Bunge) in cancer. Further clinical and experimental studies are required to assess the efficacy and safety of RG–RS in preventing the progression of cancer, osteoarthritis, and other aging-related diseases.</jats:p>
Autoren
DOI
10.3390/ph15111345
eISSN
1424-8247
Ausgabe der Veröffentlichung
11
Zeitschrift
Pharmaceuticals
Sprache
en
Online publication date
2022
Paginierung
1345 - 1345
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/ph15111345
Datum der Datenerfassung
2022
Titel
Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics
Ausgabe der Zeitschrift
15

Data source: Crossref

Abstract
<h4>Background</h4>This study aimed to assess the effect of a fixed combination of Red Ginseng and Red Sage (RG-RS) on the gene expression of neuronal cells to evaluate the potential impacts on cellular functions and predict its relevance in the treatment of stress and aging-related diseases and disorders.<h4>Methods</h4>Gene expression profiling was conducted by transcriptome-wide mRNA microarray analyses of murine HT22 hippocampal cell culture after treatment with RG-RS preparation. Ingenuity pathway analysis (IPA) was performed with datasets of significantly upregulated or downregulated genes and the expected effects on the physiological and cellular function and the diseases were identified.<h4>Results</h4>RG-RS deregulates 1028 genes associated with cancer and 139 with metastasis, suggesting a predicted decrease in tumorigenesis, the proliferation of tumor cells, tumor growth, metastasis, and an increase in apoptosis and autophagy by their effects on the various signaling and metabolic pathways, including the inhibition of Warburg's aerobic glycolysis, estrogen-mediated S-phase entry signaling, osteoarthritis signaling, and the super-pathway of cholesterol biosynthesis.<h4>Conclusion</h4>The results of this study provide evidence of the potential efficacy of the fixed combination of Red Ginseng (<i>Panax ginseng</i> C.A. Mey.) and Red Sage/Danshen (<i>Salvia miltiorrhiza</i> Bunge) in cancer. Further clinical and experimental studies are required to assess the efficacy and safety of RG-RS in preventing the progression of cancer, osteoarthritis, and other aging-related diseases.
Addresses
  • EuroPharma USA Inc., Green Bay, WI 54311, USA.
Autoren
DOI
10.3390/ph15111345
eISSN
1424-8247
Externe Identifier
  • PubMed Identifier: 36355517
  • PubMed Central ID: PMC9696821
Funding acknowledgements
  • Botalys SA: 2019-03
  • Europharma USA:
Open access
true
ISSN
1424-8247
Ausgabe der Veröffentlichung
11
Zeitschrift
Pharmaceuticals (Basel, Switzerland)
Sprache
eng
Medium
Electronic
Online publication date
2022
Open access status
Open Access
Paginierung
1345
Datum der Veröffentlichung
2022
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2022
Titel
Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
15

Files

https://www.mdpi.com/1424-8247/15/11/1345/pdf?version=1667273539 https://europepmc.org/articles/PMC9696821?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: This study aimed to assess the effect of a fixed combination of Red Ginseng and Red Sage (RG-RS) on the gene expression of neuronal cells to evaluate the potential impacts on cellular functions and predict its relevance in the treatment of stress and aging-related diseases and disorders. METHODS: Gene expression profiling was conducted by transcriptome-wide mRNA microarray analyses of murine HT22 hippocampal cell culture after treatment with RG-RS preparation. Ingenuity pathway analysis (IPA) was performed with datasets of significantly upregulated or downregulated genes and the expected effects on the physiological and cellular function and the diseases were identified. RESULTS: RG-RS deregulates 1028 genes associated with cancer and 139 with metastasis, suggesting a predicted decrease in tumorigenesis, the proliferation of tumor cells, tumor growth, metastasis, and an increase in apoptosis and autophagy by their effects on the various signaling and metabolic pathways, including the inhibition of Warburg's aerobic glycolysis, estrogen-mediated S-phase entry signaling, osteoarthritis signaling, and the super-pathway of cholesterol biosynthesis. CONCLUSION: The results of this study provide evidence of the potential efficacy of the fixed combination of Red Ginseng (Panax ginseng C.A. Mey.) and Red Sage/Danshen (Salvia miltiorrhiza Bunge) in cancer. Further clinical and experimental studies are required to assess the efficacy and safety of RG-RS in preventing the progression of cancer, osteoarthritis, and other aging-related diseases.
Date of acceptance
2022
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/36355517
DOI
10.3390/ph15111345
Externe Identifier
  • PubMed Central ID: PMC9696821
ISSN
1424-8247
Ausgabe der Veröffentlichung
11
Zeitschrift
Pharmaceuticals (Basel)
Schlüsselwörter
  • IPA pathways
  • cancer
  • gene expression
  • network pharmacology
  • red ginseng
  • red sage/danshen
  • transcriptomics
Sprache
eng
Country
Switzerland
PII
ph15111345
Datum der Veröffentlichung
2022
Status
Published online
Titel
Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
15

Data source: PubMed

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