Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Hesham R El-Seedi
- Nermeen Yosri
- Bishoy El-Aarag
- Shaymaa H Mahmoud
- Ahmed Zayed
- Ming Du
- Aamer Saeed
- Syed G Musharraf
- Islam M El-Garawani
- Mohamed R Habib
- Haroon Elrasheid Tahir
- Momtaz M Hegab
- Xiaobo Zou
- Zhiming Guo
- Thomas Efferth
- Shaden AM Khalifa
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000868132800001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/molecules27196586
- eISSN
- 1420-3049
- Externe Identifier
- Clarivate Analytics Document Solution ID: 5I1NP
- PubMed Identifier: 36235123
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- MOLECULES
- Schlüsselwörter
- anticancer
- antiviral
- anti-inflammatory
- cardiotonic steroids
- bufadienolides
- bufotalin
- bufalin
- Artikelnummer
- ARTN 6586
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads
- Sub types
- Review
- Ausgabe der Zeitschrift
- 27
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such as plants, herbs, and marines. It is well known that cardiotonic steroids reveal effects against congestive heart failure and atrial fibrillation; therefore, the term "cardiotonic" has been coined. Cardiotonic steroids are divided into two distinct groups: cardenolides (plant-derived) and bufadienolides (mainly of animal origin). Cardenolides have an unsaturated five-membered lactone ring attached to the steroid nucleus at position 17; bufadienolides have a doubly unsaturated six-membered lactone ring. Cancer is a leading cause of mortality in humans all over the world. In 2040, the global cancer load is expected to be 28.4 million cases, which would be a 47% increase from 2020. Moreover, viruses and inflammations also have a very nebative impact on human health and lead to mortality. In the current review, we focus on the chemistry, antiviral and anti-cancer activities of cardiotonic steroids from the naturally derived (toads) venom to combat these chronic devastating health problems. The databases of different research engines (Google Scholar, PubMed, Science Direct, and Sci-Finder) were screened using different combinations of the following terms: “cardiotonic steroids”, “anti-inflammatory”, “antiviral”, “anticancer”, “toad venom”, “bufadienolides”, and “poison chemical composition”. Various cardiotonic steroids were isolated from diverse toad species and exhibited superior anti-inflammatory, anticancer, and antiviral activities in in vivo and in vitro models such as marinobufagenin, gammabufotalin, resibufogenin, and bufalin. These steroids are especially difficult to identify. However, several compounds and their bioactivities were identified by using different molecular and biotechnological techniques. Biotechnology is a new tool to fully or partially generate upscaled quantities of natural products, which are otherwise only available at trace amounts in organisms.</jats:p>
- Autoren
- Hesham R El-Seedi
- Nermeen Yosri
- Bishoy El-Aarag
- Shaymaa H Mahmoud
- Ahmed Zayed
- Ming Du
- Aamer Saeed
- Syed G Musharraf
- Islam M El-Garawani
- Mohamed R Habib
- Haroon Elrasheid Tahir
- Momtaz M Hegab
- Xiaobo Zou
- Zhiming Guo
- Thomas Efferth
- Shaden AM Khalifa
- DOI
- 10.3390/molecules27196586
- eISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- Molecules
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 6586 - 6586
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/molecules27196586
- Datum der Datenerfassung
- 2022
- Titel
- Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads
- Ausgabe der Zeitschrift
- 27
Data source: Crossref
- Abstract
- Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such as plants, herbs, and marines. It is well known that cardiotonic steroids reveal effects against congestive heart failure and atrial fibrillation; therefore, the term "cardiotonic" has been coined. Cardiotonic steroids are divided into two distinct groups: cardenolides (plant-derived) and bufadienolides (mainly of animal origin). Cardenolides have an unsaturated five-membered lactone ring attached to the steroid nucleus at position 17; bufadienolides have a doubly unsaturated six-membered lactone ring. Cancer is a leading cause of mortality in humans all over the world. In 2040, the global cancer load is expected to be 28.4 million cases, which would be a 47% increase from 2020. Moreover, viruses and inflammations also have a very nebative impact on human health and lead to mortality. In the current review, we focus on the chemistry, antiviral and anti-cancer activities of cardiotonic steroids from the naturally derived (toads) venom to combat these chronic devastating health problems. The databases of different research engines (Google Scholar, PubMed, Science Direct, and Sci-Finder) were screened using different combinations of the following terms: "cardiotonic steroids", "anti-inflammatory", "antiviral", "anticancer", "toad venom", "bufadienolides", and "poison chemical composition". Various cardiotonic steroids were isolated from diverse toad species and exhibited superior anti-inflammatory, anticancer, and antiviral activities in in vivo and in vitro models such as marinobufagenin, gammabufotalin, resibufogenin, and bufalin. These steroids are especially difficult to identify. However, several compounds and their bioactivities were identified by using different molecular and biotechnological techniques. Biotechnology is a new tool to fully or partially generate upscaled quantities of natural products, which are otherwise only available at trace amounts in organisms.
- Addresses
- International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
- Autoren
- Hesham R El-Seedi
- Nermeen Yosri
- Bishoy El-Aarag
- Shaymaa H Mahmoud
- Ahmed Zayed
- Ming Du
- Aamer Saeed
- Syed G Musharraf
- Islam M El-Garawani
- Mohamed R Habib
- Haroon Elrasheid Tahir
- Momtaz M Hegab
- Xiaobo Zou
- Zhiming Guo
- Thomas Efferth
- Shaden AM Khalifa
- DOI
- 10.3390/molecules27196586
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Identifier: 36235123
- PubMed Central ID: PMC9571018
- Open access
- true
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- Molecules (Basel, Switzerland)
- Schlüsselwörter
- Animals
- Bufonidae
- Humans
- Lactones
- Bufanolides
- Cardenolides
- Cardiac Glycosides
- Hormones
- Biological Products
- Antiviral Agents
- Poisons
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 6586
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 27
Files
https://www.mdpi.com/1420-3049/27/19/6586/pdf?version=1665311622 https://europepmc.org/articles/PMC9571018?pdf=render
Data source: Europe PubMed Central
- Abstract
- Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such as plants, herbs, and marines. It is well known that cardiotonic steroids reveal effects against congestive heart failure and atrial fibrillation; therefore, the term "cardiotonic" has been coined. Cardiotonic steroids are divided into two distinct groups: cardenolides (plant-derived) and bufadienolides (mainly of animal origin). Cardenolides have an unsaturated five-membered lactone ring attached to the steroid nucleus at position 17; bufadienolides have a doubly unsaturated six-membered lactone ring. Cancer is a leading cause of mortality in humans all over the world. In 2040, the global cancer load is expected to be 28.4 million cases, which would be a 47% increase from 2020. Moreover, viruses and inflammations also have a very nebative impact on human health and lead to mortality. In the current review, we focus on the chemistry, antiviral and anti-cancer activities of cardiotonic steroids from the naturally derived (toads) venom to combat these chronic devastating health problems. The databases of different research engines (Google Scholar, PubMed, Science Direct, and Sci-Finder) were screened using different combinations of the following terms: "cardiotonic steroids", "anti-inflammatory", "antiviral", "anticancer", "toad venom", "bufadienolides", and "poison chemical composition". Various cardiotonic steroids were isolated from diverse toad species and exhibited superior anti-inflammatory, anticancer, and antiviral activities in in vivo and in vitro models such as marinobufagenin, gammabufotalin, resibufogenin, and bufalin. These steroids are especially difficult to identify. However, several compounds and their bioactivities were identified by using different molecular and biotechnological techniques. Biotechnology is a new tool to fully or partially generate upscaled quantities of natural products, which are otherwise only available at trace amounts in organisms.
- Date of acceptance
- 2022
- Autoren
- Hesham R El-Seedi
- Nermeen Yosri
- Bishoy El-Aarag
- Shaymaa H Mahmoud
- Ahmed Zayed
- Ming Du
- Aamer Saeed
- Syed G Musharraf
- Islam M El-Garawani
- Mohamed R Habib
- Haroon Elrasheid Tahir
- Momtaz M Hegab
- Xiaobo Zou
- Zhiming Guo
- Thomas Efferth
- Shaden AM Khalifa
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36235123
- DOI
- 10.3390/molecules27196586
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Central ID: PMC9571018
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- Molecules
- Schlüsselwörter
- anti-inflammatory
- anticancer
- antiviral
- bufadienolides
- bufalin
- bufotalin
- cardiotonic steroids
- Animals
- Antiviral Agents
- Biological Products
- Bufanolides
- Bufonidae
- Cardenolides
- Cardiac Glycosides
- Hormones
- Humans
- Lactones
- Poisons
- Sprache
- eng
- Country
- Switzerland
- PII
- molecules27196586
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 27
Data source: PubMed
- Beziehungen:
-