Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program

Publication type:
Journal article
Metadata:
Autoren
  • Yvonne Huber
  • Daniel Pfirrmann
  • Ines Gebhardt
  • Christian Labenz
  • Nadine Gehrke
  • Beate K Straub
  • Christian Ruckes
  • Heike Bantel
  • Eugenio Belda
  • Karine Clement
  • Diana J Leeming
  • Morten A Karsdal
  • Peter R Galle
  • Perikles Simon
  • Joern M Schattenberg
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000479552900001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1111/apt.15427
eISSN
1365-2036
Externe Identifier
  • Clarivate Analytics Document Solution ID: JC1FF
  • PubMed Identifier: 31342533
ISSN
0269-2813
Ausgabe der Veröffentlichung
8
Zeitschrift
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Paginierung
930 - 939
Datum der Veröffentlichung
2019
Status
Published
Titel
Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program
Sub types
  • Article
Ausgabe der Zeitschrift
50

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Lifestyle modifications remain the cornerstone of treatment in non‐alcoholic fatty liver disease (NAFLD). However, they requently fail related to the inability of patients to implement lasting changes.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To evaluate the effects of a short, web‐based, individualised exercise program on non‐invasive markers of hepatic steatosis, inflammation and fibrosis.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with histologically confirmed NAFLD underwent an 8‐week, web‐based, individualised exercise program that contained bidirectional feedback.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Forty‐four patients entered the study and 41 completed the assigned training goal (93.2%). In the completer population, 8 weeks of individualised exercise increased the VO<jats:sub>2peak</jats:sub> by 12.2% compared to baseline (<jats:italic>P</jats:italic> &lt; .001). ALT and AST decreased by 14.3% (<jats:italic>P</jats:italic> = .002) and 18.2% (<jats:italic>P</jats:italic> &lt; .001) and remained at this level until follow‐up 12 weeks after the intervention. Markers of inflammation including hsCRP, ferritin, and M30 decreased. In parallel, gut microbiota exhibited increased metagenomic richness (<jats:italic>P</jats:italic> &lt; .05) and at the taxonomic levels Bacteroidetes and Euryarchaeota increased whereas Actinobacteria phylum decreased. Surrogate scores of steatosis and fibrosis including the fatty liver index (FLI), FiB‐4, APRI and transient elastography showed significant reductions. In parallel, a marker of procollagen‐3 turnover (PRO‐C3) decreased while C4M2, reflecting type IV collagen, degradation increased suggesting beneficial hepatic fibrosis remodelling from exercise. Also, an enhancement in health‐related quality of life was reported.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The current study underlines the plausibility and potential of an 8 week individualised web‐based exercise program in NAFLD.</jats:p><jats:p>Clinical trial number<jats:bold>:</jats:bold> NCT02526732</jats:p></jats:sec>
Autoren
  • Yvonne Huber
  • Daniel Pfirrmann
  • Ines Gebhardt
  • Christian Labenz
  • Nadine Gehrke
  • Beate K Straub
  • Christian Ruckes
  • Heike Bantel
  • Eugenio Belda
  • Karine Clément
  • Diana J Leeming
  • Morten A Karsdal
  • Peter R Galle
  • Perikles Simon
  • Jörn M Schattenberg
DOI
10.1111/apt.15427
eISSN
1365-2036
ISSN
0269-2813
Ausgabe der Veröffentlichung
8
Zeitschrift
Alimentary Pharmacology &amp; Therapeutics
Sprache
en
Online publication date
2019
Paginierung
930 - 939
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/apt.15427
Datum der Datenerfassung
2023
Titel
Improvement of non‐invasive markers of NAFLD from an individualised, web‐based exercise program
Ausgabe der Zeitschrift
50

Data source: Crossref

Abstract
<h4>Background</h4>Lifestyle modifications remain the cornerstone of treatment in non-alcoholic fatty liver disease (NAFLD). However, they requently fail related to the inability of patients to implement lasting changes.<h4>Aims</h4>To evaluate the effects of a short, web-based, individualised exercise program on non-invasive markers of hepatic steatosis, inflammation and fibrosis.<h4>Methods</h4>Patients with histologically confirmed NAFLD underwent an 8-week, web-based, individualised exercise program that contained bidirectional feedback.<h4>Results</h4>Forty-four patients entered the study and 41 completed the assigned training goal (93.2%). In the completer population, 8 weeks of individualised exercise increased the VO<sub>2peak</sub> by 12.2% compared to baseline (P < .001). ALT and AST decreased by 14.3% (P = .002) and 18.2% (P < .001) and remained at this level until follow-up 12 weeks after the intervention. Markers of inflammation including hsCRP, ferritin, and M30 decreased. In parallel, gut microbiota exhibited increased metagenomic richness (P < .05) and at the taxonomic levels Bacteroidetes and Euryarchaeota increased whereas Actinobacteria phylum decreased. Surrogate scores of steatosis and fibrosis including the fatty liver index (FLI), FiB-4, APRI and transient elastography showed significant reductions. In parallel, a marker of procollagen-3 turnover (PRO-C3) decreased while C4M2, reflecting type IV collagen, degradation increased suggesting beneficial hepatic fibrosis remodelling from exercise. Also, an enhancement in health-related quality of life was reported.<h4>Conclusion</h4>The current study underlines the plausibility and potential of an 8 week individualised web-based exercise program in NAFLD. Clinical trial number: NCT02526732.
Addresses
  • Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Autoren
  • Yvonne Huber
  • Daniel Pfirrmann
  • Ines Gebhardt
  • Christian Labenz
  • Nadine Gehrke
  • Beate K Straub
  • Christian Ruckes
  • Heike Bantel
  • Eugenio Belda
  • Karine Clément
  • Diana J Leeming
  • Morten A Karsdal
  • Peter R Galle
  • Perikles Simon
  • Jörn M Schattenberg
DOI
10.1111/apt.15427
eISSN
1365-2036
Externe Identifier
  • PubMed Identifier: 31342533
Funding acknowledgements
  • Johannes Gutenberg-Universität Mainz:
  • European Research Council: 634413
  • Seventh Framework Programme: HEALTH-F4-2012-305312
  • German Liver Foundation:
  • Johannes Gutenberg-University Mainz:
Open access
false
ISSN
0269-2813
Ausgabe der Veröffentlichung
8
Zeitschrift
Alimentary pharmacology & therapeutics
Schlüsselwörter
  • Humans
  • Exercise
  • Exercise Therapy
  • Life Style
  • Quality of Life
  • Internet
  • Adult
  • Middle Aged
  • Female
  • Male
  • Elasticity Imaging Techniques
  • Young Adult
  • Non-alcoholic Fatty Liver Disease
  • Biomarkers
  • Precision Medicine
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Paginierung
930 - 939
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2019
Titel
Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.
Sub types
  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
50

Data source: Europe PubMed Central

Abstract
BACKGROUND: Lifestyle modifications remain the cornerstone of treatment in non-alcoholic fatty liver disease (NAFLD). However, they requently fail related to the inability of patients to implement lasting changes. AIMS: To evaluate the effects of a short, web-based, individualised exercise program on non-invasive markers of hepatic steatosis, inflammation and fibrosis. METHODS: Patients with histologically confirmed NAFLD underwent an 8-week, web-based, individualised exercise program that contained bidirectional feedback. RESULTS: Forty-four patients entered the study and 41 completed the assigned training goal (93.2%). In the completer population, 8 weeks of individualised exercise increased the VO2peak by 12.2% compared to baseline (P < .001). ALT and AST decreased by 14.3% (P = .002) and 18.2% (P < .001) and remained at this level until follow-up 12 weeks after the intervention. Markers of inflammation including hsCRP, ferritin, and M30 decreased. In parallel, gut microbiota exhibited increased metagenomic richness (P < .05) and at the taxonomic levels Bacteroidetes and Euryarchaeota increased whereas Actinobacteria phylum decreased. Surrogate scores of steatosis and fibrosis including the fatty liver index (FLI), FiB-4, APRI and transient elastography showed significant reductions. In parallel, a marker of procollagen-3 turnover (PRO-C3) decreased while C4M2, reflecting type IV collagen, degradation increased suggesting beneficial hepatic fibrosis remodelling from exercise. Also, an enhancement in health-related quality of life was reported. CONCLUSION: The current study underlines the plausibility and potential of an 8 week individualised web-based exercise program in NAFLD. Clinical trial number: NCT02526732.
Date of acceptance
2019
Autoren
  • Yvonne Huber
  • Daniel Pfirrmann
  • Ines Gebhardt
  • Christian Labenz
  • Nadine Gehrke
  • Beate K Straub
  • Christian Ruckes
  • Heike Bantel
  • Eugenio Belda
  • Karine Clément
  • Diana J Leeming
  • Morten A Karsdal
  • Peter R Galle
  • Perikles Simon
  • Jörn M Schattenberg
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31342533
DOI
10.1111/apt.15427
eISSN
1365-2036
Funding acknowledgements
  • H2020 European Research Council: 634413
  • Seventh Framework Programme: HEALTH-F4-2012-305312
  • German Liver Foundation:
  • Johannes Gutenberg-University Mainz:
Ausgabe der Veröffentlichung
8
Zeitschrift
Aliment Pharmacol Ther
Schlüsselwörter
  • Adult
  • Biomarkers
  • Elasticity Imaging Techniques
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Internet
  • Life Style
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease
  • Precision Medicine
  • Quality of Life
  • Young Adult
Sprache
eng
Country
England
Paginierung
930 - 939
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.
Sub types
  • Clinical Trial
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
50

Data source: PubMed

Beziehungen:
Property of

Tools