Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Alexander Panossian
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000859534400001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/ph15091051
- eISSN
- 1424-8247
- Externe Identifier
- Clarivate Analytics Document Solution ID: 4V5RO
- PubMed Identifier: 36145272
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- PHARMACEUTICALS
- Schlüsselwörter
- network pharmacology
- adaptogens
- gene expression
- pleiotropic action
- nonspecific
- specific action
- Artikelnummer
- ARTN 1051
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
- Sub types
- Review
- Ausgabe der Zeitschrift
- 15
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified.</jats:p>
- Autoren
- Alexander Panossian
- Thomas Efferth
- DOI
- 10.3390/ph15091051
- eISSN
- 1424-8247
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Pharmaceuticals
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 1051 - 1051
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/ph15091051
- Datum der Datenerfassung
- 2022
- Titel
- Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
- Ausgabe der Zeitschrift
- 15
Data source: Crossref
- Abstract
- The reductionist concept, based on the ligand-receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified.
- Addresses
- Phytomed AB, Bofinkvagen 1, 31275 Vaxtorp, Sweden.
- Autoren
- Alexander Panossian
- Thomas Efferth
- DOI
- 10.3390/ph15091051
- eISSN
- 1424-8247
- Externe Identifier
- PubMed Identifier: 36145272
- PubMed Central ID: PMC9504187
- Open access
- true
- ISSN
- 1424-8247
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Pharmaceuticals (Basel, Switzerland)
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 1051
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 15
Files
https://www.mdpi.com/1424-8247/15/9/1051/pdf?version=1661494293 https://europepmc.org/articles/PMC9504187?pdf=render
Data source: Europe PubMed Central
- Abstract
- The reductionist concept, based on the ligand-receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified.
- Date of acceptance
- 2022
- Autoren
- Alexander Panossian
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36145272
- DOI
- 10.3390/ph15091051
- Externe Identifier
- PubMed Central ID: PMC9504187
- ISSN
- 1424-8247
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Pharmaceuticals (Basel)
- Schlüsselwörter
- adaptogens
- gene expression
- network pharmacology
- nonspecific
- pleiotropic action
- specific action
- Sprache
- eng
- Country
- Switzerland
- PII
- ph15091051
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Titel
- Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 15
Data source: PubMed
- Beziehungen:
- Property of