OXTR-Related Markers in Clinical Depression: a Longitudinal Case–Control Psychotherapy Study
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>We investigated stability and change of plasma and urinary oxytocin as well as <jats:italic>OXTR</jats:italic> DNA methylation patterns through psychotherapy. Furthermore, we explored the potential impact of inpatient psychotherapy on oxytocin-related biomarkers and vice versa by differentiating patients who remitted from depression versus non-remitters. Blood and urine samples were taken from 85 premenopausal women (aged 19–52), 43 clinically depressed patients from a psychosomatic inpatient unit, and 42 healthy control subjects matched for age and education at two points of time. Serum and urine oxytocin were measured using standard ELISA, and DNA methylation of the <jats:italic>OXTR</jats:italic> gene was assessed using bisulfite sequencing at the time of admission (baseline) and at discharge and from controls at matched time points. Oxytocin plasma levels were not associated with depression and were influenced by neither time in healthy controls nor psychotherapy in patients. Non-remitting depressed patients had significantly lower oxytocin urine levels before and after psychotherapy treatment. We found significantly lower exon 1 <jats:italic>OTXR</jats:italic> methylation in depressed patients over time and these differences were driven by patients remitting due to psychotherapy. A reverse pattern — higher levels of methylation in remitters — was found for exon 2 <jats:italic>OXTR</jats:italic> DNA methylation. Plasma oxytocin, urinary oxytocin, and <jats:italic>OXTR</jats:italic> DNA methylation patterns were intrapersonally relatively stable. <jats:italic>OXTR</jats:italic>-related factors were seemingly unaffected by inpatient psychotherapeutic treatment, but we found significant differences between remitting and non-remitting patients in urinary oxytocin and <jats:italic>OXTR</jats:italic> DNA methylation. If replicated, this suggests that <jats:italic>OXTR</jats:italic>-related markers may predict inpatient treatment outcomes of clinically depressed patients.</jats:p>
- Autoren
- Iris C Reiner
- Gerald Gimpl
- Manfred E Beutel
- Marian J Bakermans-Kranenburg
- Helge Frieling
- DOI
- 10.1007/s12031-021-01930-7
- eISSN
- 1559-1166
- ISSN
- 0895-8696
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Journal of Molecular Neuroscience
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 695 - 707
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s12031-021-01930-7
- Datum der Datenerfassung
- 2022
- Titel
- OXTR-Related Markers in Clinical Depression: a Longitudinal Case–Control Psychotherapy Study
- Ausgabe der Zeitschrift
- 72
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Iris C Reiner
- Gerald Gimpl
- Manfred E Beutel
- Marian J Bakermans-Kranenburg
- Helge Frieling
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1007/s12031-021-01930-7
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1559-1166
- Zeitschrift
- Journal of molecular neuroscience
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 695 - 707
- Datum der Veröffentlichung
- 2022
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7671
- Herausgeber
- Springer
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- OXTR-related markers in clinical depression : a longitudinal case-control psychotherapy study
- Ausgabe der Zeitschrift
- 72
Files
oxtrrelated_markers_in_clinic-20220829144718037.pdf
Data source: OPENSCIENCE.UB