Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Aims</jats:title> <jats:p>To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.</jats:p> </jats:sec><jats:sec> <jats:title>Methods and Results</jats:title> <jats:p>The study sample comprised 15,010 individuals aged 35–74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (<jats:italic>n</jats:italic> = 1415) and of T2DM 8.9% (<jats:italic>n</jats:italic> = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, <jats:italic>P</jats:italic> &lt; 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PR<jats:sub>prediabetes</jats:sub> 1.20, 95% CI 1.07–1.35, <jats:italic>P</jats:italic> = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01–1.08, <jats:italic>P</jats:italic> = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76–2.51, <jats:italic>P</jats:italic> &lt; 0.0001) and T2DM (HR 4.28, 95% CI 3.73–4.92, <jats:italic>P</jats:italic> &lt; 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63–2.20, <jats:italic>P</jats:italic> &lt; 0.0001) remained independently associated with increased all-cause mortality.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.</jats:p> </jats:sec>
Autoren
  • Volker H Schmitt
  • Anja Leuschner
  • Claus Jünger
  • Antonio Pinto
  • Omar Hahad
  • Andreas Schulz
  • Natalie Arnold
  • Sven-Oliver Tröbs
  • Marina Panova-Noeva
  • Karsten Keller
  • Tanja Zeller
  • Manfred Beutel
  • Norbert Pfeiffer
  • Konstantin Strauch
  • Stefan Blankenberg
  • Karl J Lackner
  • Jürgen H Prochaska
  • Philipp S Wild
  • Thomas Münzel
DOI
10.1007/s00392-021-01879-y
eISSN
1861-0692
ISSN
1861-0684
Ausgabe der Veröffentlichung
3
Zeitschrift
Clinical Research in Cardiology
Sprache
en
Online publication date
2021
Paginierung
272 - 283
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00392-021-01879-y
Datum der Datenerfassung
2022
Titel
Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study
Ausgabe der Zeitschrift
111

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Volker H Schmitt
  • Anja Leuschner
  • Claus Jünger
  • Antonio Pinto
  • Omar Hahad
  • Andreas Schulz
  • Natalie Arnold
  • Sven-Oliver Tröbs
  • Marina Panova-Noeva
  • Karsten Keller
  • Tanja Zeller
  • Manfred Beutel
  • Norbert Pfeiffer
  • Konstantin Strauch
  • Stefan Blankenberg
  • Karl J Lackner
  • Jürgen H Prochaska
  • Philipp S Wild
  • Thomas Münzel
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1007/s00392-021-01879-y
File(s) embargoed
false
Open access
true
ISSN
1861-0692
Zeitschrift
Clinical research in cardiology
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
272 - 283
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7624
Herausgeber
Springer
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Cardiovascular profiling in the diabetic continuum : results from the population-based Gutenberg Health Study
Ausgabe der Zeitschrift
111

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cardiovascular_profiling_in_t-20220822152839427.pdf

Data source: OPENSCIENCE.UB

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