Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000858554400001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2022.154347
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 4U1HS
  • PubMed Identifier: 35914361
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Knee osteoarthritis
  • Medicinal plants
  • Molecular pharmacology
  • Phytotherapy
  • Secondary metabolites
Artikelnummer
ARTN 154347
Datum der Veröffentlichung
2022
Status
Published
Titel
Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review
Sub types
  • Review
Ausgabe der Zeitschrift
105

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000861364700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=7c6cbd95cc08067bf5cec85ffdc20efd
DOI
10.1016/j.phymed.2022.154347
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 4Y2MQ
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Knee osteoarthritis
  • Medicinal plants
  • Molecular pharmacology
  • Phytotherapy
  • Secondary metabolites
Artikelnummer
ARTN 154347
Datum der Veröffentlichung
2022
Status
Published
Titel
Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review
Sub types
  • Review
Ausgabe der Zeitschrift
105

Data source: Web of Science (Lite)

Autoren
DOI
10.1016/j.phymed.2022.154347
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
154347
Paginierung
154347 - 154347
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2022.154347
Datum der Datenerfassung
2024
Titel
Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review
Ausgabe der Zeitschrift
105

Data source: Crossref

Abstract
<h4>Background</h4>With the increasing ages of the general population, the incidence of knee osteoarthritis (KOA) is also rising, and KOA has become a major health problem worldwide. Recently, medicinal plants and their secondary metabolites have gained interest due to their activity in treating KOA. In this paper, a comprehensive systematic review of the literature was performed concerning the effects of medicinal plant extracts and natural compounds against KOA in recent years. The related molecular pathways of natural compounds against KOA were summarized, and the possible crosstalk among components in chondrocytes was discussed to propose possible solutions for the current situation of treating KOA.<h4>Purpose</h4>This review focused on the molecular mechanisms by which medicinal plants and their secondary metabolites act against KOA.<h4>Methods</h4>Literature searches were performed in the PUBMED, Embase, Science Direct, and Web of Science databases for a 10-year period from 2011 to 2022 with the search terms "medicinal plants," "bioactive compounds," "natural products," "phytochemical," "knee osteoarthritis," "knee joint osteoarthritis," "knee osteoarthritis," "osteoarthritis of the knee," and "osteoarthritis of knee joint."<h4>Results</h4>According to the results, substantial plant extracts and secondary metabolites show a positive effect in fighting KOA. Plant extracts and their secondary metabolites can affect the diagnostic and prognostic biomarkers of KOA. Natural products inhibit the expression of MMP1, MMP3, MMP19, syndecan IV, ADAMTS-4, ADAMTS-5, iNOS, COX-2, collagenases, IL-6, IL-1β, and TNF-α in vitro and in vivo and . Cytokines also upregulate the expression of collagen II and aggrecan. The main signaling pathways affected by the extracts and isolated compounds include AMPK, SIRT, NLRP3, MAPKs, PI3K/AKT, mTOR, NF-κB, WNT/β-catenin, JAK/STAT3, and NRF2, as well as the cell death modes apoptosis, autophagy, pyroptosis, and ferroptosis.<h4>Conclusion</h4>The role of secondary metabolites in different signaling pathways supplies a better understanding of their potential to develop further curative options for KOA.
Addresses
  • School of Kinesiology, Shenyang Sport University, No. 36 Jinqiansong East Road, Shenyang, China.
Autoren
DOI
10.1016/j.phymed.2022.154347
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 35914361
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Plants, Medicinal
  • Osteoarthritis, Knee
  • NF-kappa B
  • Plant Extracts
  • Phosphatidylinositol 3-Kinases
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Paginierung
154347
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review.
Sub types
  • Systematic Review
  • Review
  • Journal Article
Ausgabe der Zeitschrift
105

Data source: Europe PubMed Central

Abstract
BACKGROUND: With the increasing ages of the general population, the incidence of knee osteoarthritis (KOA) is also rising, and KOA has become a major health problem worldwide. Recently, medicinal plants and their secondary metabolites have gained interest due to their activity in treating KOA. In this paper, a comprehensive systematic review of the literature was performed concerning the effects of medicinal plant extracts and natural compounds against KOA in recent years. The related molecular pathways of natural compounds against KOA were summarized, and the possible crosstalk among components in chondrocytes was discussed to propose possible solutions for the current situation of treating KOA. PURPOSE: This review focused on the molecular mechanisms by which medicinal plants and their secondary metabolites act against KOA. METHODS: Literature searches were performed in the PUBMED, Embase, Science Direct, and Web of Science databases for a 10-year period from 2011 to 2022 with the search terms "medicinal plants," "bioactive compounds," "natural products," "phytochemical," "knee osteoarthritis," "knee joint osteoarthritis," "knee osteoarthritis," "osteoarthritis of the knee," and "osteoarthritis of knee joint." RESULTS: According to the results, substantial plant extracts and secondary metabolites show a positive effect in fighting KOA. Plant extracts and their secondary metabolites can affect the diagnostic and prognostic biomarkers of KOA. Natural products inhibit the expression of MMP1, MMP3, MMP19, syndecan IV, ADAMTS-4, ADAMTS-5, iNOS, COX-2, collagenases, IL-6, IL-1β, and TNF-α in vitro and in vivo and . Cytokines also upregulate the expression of collagen II and aggrecan. The main signaling pathways affected by the extracts and isolated compounds include AMPK, SIRT, NLRP3, MAPKs, PI3K/AKT, mTOR, NF-κB, WNT/β-catenin, JAK/STAT3, and NRF2, as well as the cell death modes apoptosis, autophagy, pyroptosis, and ferroptosis. CONCLUSION: The role of secondary metabolites in different signaling pathways supplies a better understanding of their potential to develop further curative options for KOA.
Date of acceptance
2022
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35914361
DOI
10.1016/j.phymed.2022.154347
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Knee osteoarthritis
  • Medicinal plants
  • Molecular pharmacology
  • Phytotherapy
  • Secondary metabolites
  • Humans
  • NF-kappa B
  • Osteoarthritis, Knee
  • Phosphatidylinositol 3-Kinases
  • Plant Extracts
  • Plants, Medicinal
Sprache
eng
Country
Germany
Paginierung
154347
PII
S0944-7113(22)00426-3
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review.
Sub types
  • Journal Article
  • Review
  • Systematic Review
Ausgabe der Zeitschrift
105

Data source: PubMed

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