Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Jose JG Marin
- Maria J Monte
- Rocio IR Macias
- Marta R Romero
- Elisa Herraez
- Maitane Asensio
- Sara Ortiz-Rivero
- Candela Cives-Losada
- Silvia Di Giacomo
- Javier Gonzalez-Gallego
- Jose L Mauriz
- Thomas Efferth
- Oscar Briz
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000832400600001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/cancers14143524
- eISSN
- 2072-6694
- Externe Identifier
- Clarivate Analytics Document Solution ID: 3I0EV
- PubMed Identifier: 35884584
- Ausgabe der Veröffentlichung
- 14
- Zeitschrift
- CANCERS
- Schlüsselwörter
- ATP-binding cassette protein
- anticancer drug
- drug refractoriness
- multidrug resistance
- transport
- Artikelnummer
- ARTN 3524
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers
- Sub types
- Review
- Ausgabe der Zeitschrift
- 14
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>Hepatobiliary, pancreatic, and gastrointestinal cancers account for 36% of the ten million deaths caused by cancer worldwide every year. The two main reasons for this high mortality are their late diagnosis and their high refractoriness to pharmacological treatments, regardless of whether these are based on classical chemotherapeutic agents, targeted drugs, or newer immunomodulators. Mechanisms of chemoresistance (MOC) defining the multidrug resistance (MDR) phenotype of each tumor depend on the synergic function of proteins encoded by more than one hundred genes classified into seven groups (MOC1-7). Among them, the efflux of active agents from cancer cells across the plasma membrane caused by members of the superfamily of ATP-binding cassette (ABC) proteins (MOC-1b) plays a crucial role in determining tumor MDR. Although seven families of human ABC proteins are known, only a few pumps (mainly MDR1, MRP1-6, and BCRP) have been associated with reducing drug content and hence inducing chemoresistance in hepatobiliary, pancreatic, and gastrointestinal cancer cells. The present descriptive review, which compiles the updated information on the expression of these ABC proteins, will be helpful because there is still some confusion on the actual relevance of these pumps in response to pharmacological regimens currently used in treating these cancers. Moreover, we aim to define the MOC pattern on a tumor-by-tumor basis, even in a dynamic way, because it can vary during tumor progression and in response to chemotherapy. This information is indispensable for developing novel strategies for sensitization.</jats:p>
- Autoren
- Jose Marin
- Maria Monte
- Rocio Macias
- Marta Romero
- Elisa Herraez
- Maitane Asensio
- Sara Ortiz-Rivero
- Candela Cives-Losada
- Silvia Di Giacomo
- Javier Gonzalez-Gallego
- Jose Mauriz
- Thomas Efferth
- Oscar Briz
- DOI
- 10.3390/cancers14143524
- eISSN
- 2072-6694
- Ausgabe der Veröffentlichung
- 14
- Zeitschrift
- Cancers
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 3524 - 3524
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/cancers14143524
- Datum der Datenerfassung
- 2022
- Titel
- Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers
- Ausgabe der Zeitschrift
- 14
Data source: Crossref
- Abstract
- Hepatobiliary, pancreatic, and gastrointestinal cancers account for 36% of the ten million deaths caused by cancer worldwide every year. The two main reasons for this high mortality are their late diagnosis and their high refractoriness to pharmacological treatments, regardless of whether these are based on classical chemotherapeutic agents, targeted drugs, or newer immunomodulators. Mechanisms of chemoresistance (MOC) defining the multidrug resistance (MDR) phenotype of each tumor depend on the synergic function of proteins encoded by more than one hundred genes classified into seven groups (MOC1-7). Among them, the efflux of active agents from cancer cells across the plasma membrane caused by members of the superfamily of ATP-binding cassette (ABC) proteins (MOC-1b) plays a crucial role in determining tumor MDR. Although seven families of human ABC proteins are known, only a few pumps (mainly MDR1, MRP1-6, and BCRP) have been associated with reducing drug content and hence inducing chemoresistance in hepatobiliary, pancreatic, and gastrointestinal cancer cells. The present descriptive review, which compiles the updated information on the expression of these ABC proteins, will be helpful because there is still some confusion on the actual relevance of these pumps in response to pharmacological regimens currently used in treating these cancers. Moreover, we aim to define the MOC pattern on a tumor-by-tumor basis, even in a dynamic way, because it can vary during tumor progression and in response to chemotherapy. This information is indispensable for developing novel strategies for sensitization.
- Addresses
- Experimental Hepatology and Drug Targeting (HEVEPHARM) Group, University of Salamanca, IBSAL, 37007 Salamanca, Spain.
- Autoren
- Jose JG Marin
- Maria J Monte
- Rocio IR Macias
- Marta R Romero
- Elisa Herraez
- Maitane Asensio
- Sara Ortiz-Rivero
- Candela Cives-Losada
- Silvia Di Giacomo
- Javier Gonzalez-Gallego
- Jose L Mauriz
- Thomas Efferth
- Oscar Briz
- DOI
- 10.3390/cancers14143524
- eISSN
- 2072-6694
- Externe Identifier
- PubMed Identifier: 35884584
- PubMed Central ID: PMC9320734
- Funding acknowledgements
- Fundació Marato TV3: 201916-31
- Instituto de Salud Carlos III: PI19/00819, PI20/00189
- Spanish Ministry of Science and Innovation: MCIN/AEI/10.13039/501100011033, PID2020-119164RB-I00
- Junta de Castilla y León: SA074P20
- Open access
- true
- ISSN
- 2072-6694
- Ausgabe der Veröffentlichung
- 14
- Zeitschrift
- Cancers
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 3524
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 14
Files
https://www.mdpi.com/2072-6694/14/14/3524/pdf?version=1663293315 https://europepmc.org/articles/PMC9320734?pdf=render
Data source: Europe PubMed Central
- Abstract
- Hepatobiliary, pancreatic, and gastrointestinal cancers account for 36% of the ten million deaths caused by cancer worldwide every year. The two main reasons for this high mortality are their late diagnosis and their high refractoriness to pharmacological treatments, regardless of whether these are based on classical chemotherapeutic agents, targeted drugs, or newer immunomodulators. Mechanisms of chemoresistance (MOC) defining the multidrug resistance (MDR) phenotype of each tumor depend on the synergic function of proteins encoded by more than one hundred genes classified into seven groups (MOC1-7). Among them, the efflux of active agents from cancer cells across the plasma membrane caused by members of the superfamily of ATP-binding cassette (ABC) proteins (MOC-1b) plays a crucial role in determining tumor MDR. Although seven families of human ABC proteins are known, only a few pumps (mainly MDR1, MRP1-6, and BCRP) have been associated with reducing drug content and hence inducing chemoresistance in hepatobiliary, pancreatic, and gastrointestinal cancer cells. The present descriptive review, which compiles the updated information on the expression of these ABC proteins, will be helpful because there is still some confusion on the actual relevance of these pumps in response to pharmacological regimens currently used in treating these cancers. Moreover, we aim to define the MOC pattern on a tumor-by-tumor basis, even in a dynamic way, because it can vary during tumor progression and in response to chemotherapy. This information is indispensable for developing novel strategies for sensitization.
- Date of acceptance
- 2022
- Autoren
- Jose JG Marin
- Maria J Monte
- Rocio IR Macias
- Marta R Romero
- Elisa Herraez
- Maitane Asensio
- Sara Ortiz-Rivero
- Candela Cives-Losada
- Silvia Di Giacomo
- Javier Gonzalez-Gallego
- Jose L Mauriz
- Thomas Efferth
- Oscar Briz
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35884584
- DOI
- 10.3390/cancers14143524
- Externe Identifier
- PubMed Central ID: PMC9320734
- Funding acknowledgements
- Instituto de Salud Carlos III: PI19/00819, PI20/00189
- Spanish Ministry of Science and Innovation: MCIN/AEI/10.13039/501100011033, PID2020-119164RB-I00
- Junta de Castilla y León: SA074P20
- Fundació Marato TV3: 201916-31
- ISSN
- 2072-6694
- Ausgabe der Veröffentlichung
- 14
- Zeitschrift
- Cancers (Basel)
- Schlüsselwörter
- ATP-binding cassette protein
- anticancer drug
- drug refractoriness
- multidrug resistance
- transport
- Sprache
- eng
- Country
- Switzerland
- PII
- cancers14143524
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Titel
- Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 14
Data source: PubMed
- Beziehungen:
- Property of