Untapping the protective role of carotenoids against respiratory diseases

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000831816300004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2022.154286
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 3H1QL
  • PubMed Identifier: 35820304
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Carotenoids
  • In vitro and in vivo models
  • NRF2/HO-1 pathway
  • Phytochemicals
  • Respiratory diseases
  • Terpenoids
Artikelnummer
ARTN 154286
Datum der Veröffentlichung
2022
Status
Published
Titel
Untapping the protective role of carotenoids against respiratory diseases
Sub types
  • Review
Ausgabe der Zeitschrift
104

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2022.154286
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
154286
Paginierung
154286 - 154286
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2022.154286
Datum der Datenerfassung
2024
Titel
Untapping the protective role of carotenoids against respiratory diseases
Ausgabe der Zeitschrift
104

Data source: Crossref

Abstract
<h4>Background</h4>Recent studies revealed a substantial role of carotenoids to treat respiratory diseases. This review aimed to give an updated overview of the investigational evidence on the preventive properties of carotenoids against respiratory diseases both in vitro and in vivo along with their pathophysiology and mechanisms of action.<h4>Hypothesis</h4>Carotenoids as a potential therapeutic class of bioactive compounds to treat respiratory diseases.<h4>Results</h4>Carotenoids such as β-carotene, lycopene, crocin, bixin, lutein, and astaxanthin show beneficial effects against chronic lung diseases (e.g., asthma, emphysema, fibrosis, COPD, acute lung injury, and lung cancer). Moreover, in vitro and in vivo studies also supported the preventive role of carotenoids. These carotenoids showed a beneficial role by activation of the NRF2/HO-1 pathway and inhibition of the NF-кB, MAPK, JAK/STAT-3, and PI3K/AKT pathways. Additionally, epidemiological studies also showed that dietary intake of carotenoids lowers the risk of lung diseases.<h4>Conclusion</h4>Carotenoids may be used as drugs or can be given in combination with other drugs to prevent and treat respiratory diseases. Although in vitro and in vivo results are encouraging, further well-conducted randomized clinical trials are required to approve carotenoids as drug candidates.
Addresses
  • School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014 Tamil Nadu, India.
Autoren
DOI
10.1016/j.phymed.2022.154286
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 35820304
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Carotenoids
  • Antioxidants
  • Acute Lung Injury
  • Phosphatidylinositol 3-Kinases
  • Lycopene
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Paginierung
154286
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Untapping the protective role of carotenoids against respiratory diseases.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
104

Data source: Europe PubMed Central

Abstract
BACKGROUND: Recent studies revealed a substantial role of carotenoids to treat respiratory diseases. This review aimed to give an updated overview of the investigational evidence on the preventive properties of carotenoids against respiratory diseases both in vitro and in vivo along with their pathophysiology and mechanisms of action. HYPOTHESIS: Carotenoids as a potential therapeutic class of bioactive compounds to treat respiratory diseases. RESULTS: Carotenoids such as β-carotene, lycopene, crocin, bixin, lutein, and astaxanthin show beneficial effects against chronic lung diseases (e.g., asthma, emphysema, fibrosis, COPD, acute lung injury, and lung cancer). Moreover, in vitro and in vivo studies also supported the preventive role of carotenoids. These carotenoids showed a beneficial role by activation of the NRF2/HO-1 pathway and inhibition of the NF-кB, MAPK, JAK/STAT-3, and PI3K/AKT pathways. Additionally, epidemiological studies also showed that dietary intake of carotenoids lowers the risk of lung diseases. CONCLUSION: Carotenoids may be used as drugs or can be given in combination with other drugs to prevent and treat respiratory diseases. Although in vitro and in vivo results are encouraging, further well-conducted randomized clinical trials are required to approve carotenoids as drug candidates.
Date of acceptance
2022
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35820304
DOI
10.1016/j.phymed.2022.154286
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Carotenoids
  • In vitro and in vivo models
  • NRF2/HO-1 pathway
  • Phytochemicals
  • Respiratory diseases
  • Terpenoids
  • Acute Lung Injury
  • Antioxidants
  • Carotenoids
  • Humans
  • Lycopene
  • Phosphatidylinositol 3-Kinases
Sprache
eng
Country
Germany
Paginierung
154286
PII
S0944-7113(22)00365-8
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Untapping the protective role of carotenoids against respiratory diseases.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
104

Data source: PubMed

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