Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Glomerular filtration rate (GFR) declines with age by approx. 1 ml/min/m<jats:sup>2</jats:sup> per year beginning in the third decade of life. At 70 years of age > 40 ml/min/m<jats:sup>2</jats:sup> of GFR will be lost. Thus, factors affecting loss of GFR have significant public health implications. Furthermore, the definition of chronic kidney disease based on GFR may not be appropriate for the elderly. We analyzed factors affecting absolute and relative change of eGFR over a 5 year period in 12,381 participants of the Gutenberg Health Study. We estimated GFR at baseline and after 5 years of follow-up by two different equations. Association with the decline of estimated GFR (eGFR) was assessed by multivariable regression analysis. We confirmed a median loss of eGFR per year of approx. 1 ml/min/m<jats:sup>2</jats:sup>. Aside from albuminuria systolic blood pressure was most strongly associated with faster decline of eGFR followed by echocardiographic evidence of left ventricular diastolic dysfunction and reduced ejection fraction. White blood cell count showed a moderate association with eGFR loss. Diastolic blood pressure, serum uric acid and serum albumin were associated with slower GFR decline in multivariable analysis. Sensitivity analysis with exclusion of individuals taking diuretics, antihypertensive, antidiabetic, or lipid lowering drugs confirmed these associations.</jats:p>
- Autoren
- Thomas Waas
- Andreas Schulz
- Johannes Lotz
- Heidi Rossmann
- Norbert Pfeiffer
- Manfred E Beutel
- Irene Schmidtmann
- Thomas Münzel
- Philipp S Wild
- Karl J Lackner
- DOI
- 10.1038/s41598-021-89442-7
- eISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific Reports
- Sprache
- en
- Artikelnummer
- 10165
- Online publication date
- 2021
- Status
- Published online
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-021-89442-7
- Datum der Datenerfassung
- 2022
- Titel
- Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
- Ausgabe der Zeitschrift
- 11
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Thomas Waas
- Andreas Schulz
- Johannes Lotz
- Heidi Rossmann
- Norbert Pfeiffer
- Manfred E Beutel
- Irene Schmidtmann
- Thomas Münzel
- Philipp S Wild
- Karl J Lackner
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1038/s41598-021-89442-7
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2045-2322
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 10165
- Datum der Veröffentlichung
- 2021
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7317
- Herausgeber
- Macmillan Publishers Limited, part of Springer Nature
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
- Ausgabe der Zeitschrift
- 11
Files
distribution_of_estimated_glo-20220705100428008.pdf
Data source: OPENSCIENCE.UB