Gene expression patterns underlying parasite-induced alterations in host behaviour and life history
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Barbara Feldmeyer
- Johanna Mazur
- Sara Beros
- Hannes Lerp
- Harald Binder
- Susanne Foitzik
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000369530000015&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1111/mec.13498
- eISSN
- 1365-294X
- Externe Identifier
- Clarivate Analytics Document Solution ID: DC9GU
- PubMed Identifier: 26615010
- ISSN
- 0962-1083
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- MOLECULAR ECOLOGY
- Schlüsselwörter
- behavioural manipulation
- extended phenotype
- host-parasite interactions
- insects
- transcriptome
- Paginierung
- 648 - 660
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Gene expression patterns underlying parasite-induced alterations in host behaviour and life history
- Sub types
- Article
- Ausgabe der Zeitschrift
- 25
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Many parasites manipulate their hosts’ phenotype. In particular, parasites with complex life cycles take control of their intermediate hosts’ behaviour and life history to increase transmission to their definitive host. The proximate mechanisms underlying these parasite‐induced alterations are poorly understood. The cestode <jats:italic>Anomotaenia brevis</jats:italic> affects the behaviour, life history and morphology of parasitized <jats:italic>Temnothorax nylanderi</jats:italic> ants and indirectly of their unparasitized nestmates. To gain insights on how parasites alter host phenotypes, we contrast brain gene expression patterns of <jats:italic>T. nylanderi</jats:italic> workers parasitized with the cestode, their unparasitized nestmates and unparasitized workers from unparasitized colonies. Over 400 differentially expressed genes between the three groups were identified, with most uniquely expressed genes detected in parasitized workers. Among these are genes that can be linked to the increased lifespan of parasitized workers. Furthermore, many muscle (functionality) genes are downregulated in these workers, potentially causing the observed muscular deformations and their inactive behaviour. Alterations in lifespan and activity could be adaptive for the parasite by increasing the likelihood that infected workers residing in acorns are eaten by their definitive host, a woodpecker. Our transcriptome analysis reveals numerous gene expression changes in parasitized workers and their uninfected nestmates and indicates possible routes of parasite manipulation. Although causality still needs to be established, parasite‐induced alterations in lifespan and host behaviour appear to be partly explained by morphological muscle atrophy instead of central nervous system interference, which is often the core of behavioural regulation. Results of this study will shed light upon the molecular basis of antagonistic species interactions.</jats:p>
- Autoren
- Barbara Feldmeyer
- Johanna Mazur
- Sara Beros
- Hannes Lerp
- Harald Binder
- Susanne Foitzik
- DOI
- 10.1111/mec.13498
- eISSN
- 1365-294X
- ISSN
- 0962-1083
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Molecular Ecology
- Sprache
- en
- Online publication date
- 2016
- Paginierung
- 648 - 660
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1111/mec.13498
- Datum der Datenerfassung
- 2023
- Titel
- Gene expression patterns underlying parasite‐induced alterations in host behaviour and life history
- Ausgabe der Zeitschrift
- 25
Data source: Crossref
- Abstract
- Many parasites manipulate their hosts' phenotype. In particular, parasites with complex life cycles take control of their intermediate hosts' behaviour and life history to increase transmission to their definitive host. The proximate mechanisms underlying these parasite-induced alterations are poorly understood. The cestode Anomotaenia brevis affects the behaviour, life history and morphology of parasitized Temnothorax nylanderi ants and indirectly of their unparasitized nestmates. To gain insights on how parasites alter host phenotypes, we contrast brain gene expression patterns of T. nylanderi workers parasitized with the cestode, their unparasitized nestmates and unparasitized workers from unparasitized colonies. Over 400 differentially expressed genes between the three groups were identified, with most uniquely expressed genes detected in parasitized workers. Among these are genes that can be linked to the increased lifespan of parasitized workers. Furthermore, many muscle (functionality) genes are downregulated in these workers, potentially causing the observed muscular deformations and their inactive behaviour. Alterations in lifespan and activity could be adaptive for the parasite by increasing the likelihood that infected workers residing in acorns are eaten by their definitive host, a woodpecker. Our transcriptome analysis reveals numerous gene expression changes in parasitized workers and their uninfected nestmates and indicates possible routes of parasite manipulation. Although causality still needs to be established, parasite-induced alterations in lifespan and host behaviour appear to be partly explained by morphological muscle atrophy instead of central nervous system interference, which is often the core of behavioural regulation. Results of this study will shed light upon the molecular basis of antagonistic species interactions.
- Addresses
- Evolutionary Biology, Johannes Gutenberg University Mainz, Johannes-von-Müller-Weg 6, 55128, Mainz, Germany.
- Autoren
- Barbara Feldmeyer
- Johanna Mazur
- Sara Beros
- Hannes Lerp
- Harald Binder
- Susanne Foitzik
- DOI
- 10.1111/mec.13498
- eISSN
- 1365-294X
- Externe Identifier
- PubMed Identifier: 26615010
- Open access
- false
- ISSN
- 0962-1083
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Molecular ecology
- Schlüsselwörter
- Animals
- Ants
- Cestoda
- Cluster Analysis
- Behavior, Animal
- Longevity
- Phenotype
- Genes, Insect
- Host-Parasite Interactions
- Transcriptome
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 648 - 660
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- Gene expression patterns underlying parasite-induced alterations in host behaviour and life history.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 25
Data source: Europe PubMed Central
- Abstract
- Many parasites manipulate their hosts' phenotype. In particular, parasites with complex life cycles take control of their intermediate hosts' behaviour and life history to increase transmission to their definitive host. The proximate mechanisms underlying these parasite-induced alterations are poorly understood. The cestode Anomotaenia brevis affects the behaviour, life history and morphology of parasitized Temnothorax nylanderi ants and indirectly of their unparasitized nestmates. To gain insights on how parasites alter host phenotypes, we contrast brain gene expression patterns of T. nylanderi workers parasitized with the cestode, their unparasitized nestmates and unparasitized workers from unparasitized colonies. Over 400 differentially expressed genes between the three groups were identified, with most uniquely expressed genes detected in parasitized workers. Among these are genes that can be linked to the increased lifespan of parasitized workers. Furthermore, many muscle (functionality) genes are downregulated in these workers, potentially causing the observed muscular deformations and their inactive behaviour. Alterations in lifespan and activity could be adaptive for the parasite by increasing the likelihood that infected workers residing in acorns are eaten by their definitive host, a woodpecker. Our transcriptome analysis reveals numerous gene expression changes in parasitized workers and their uninfected nestmates and indicates possible routes of parasite manipulation. Although causality still needs to be established, parasite-induced alterations in lifespan and host behaviour appear to be partly explained by morphological muscle atrophy instead of central nervous system interference, which is often the core of behavioural regulation. Results of this study will shed light upon the molecular basis of antagonistic species interactions.
- Date of acceptance
- 2015
- Autoren
- Barbara Feldmeyer
- Johanna Mazur
- Sara Beros
- Hannes Lerp
- Harald Binder
- Susanne Foitzik
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/26615010
- DOI
- 10.1111/mec.13498
- eISSN
- 1365-294X
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Mol Ecol
- Schlüsselwörter
- behavioural manipulation
- extended phenotype
- host-parasite interactions
- insects
- transcriptome
- Animals
- Ants
- Behavior, Animal
- Cestoda
- Cluster Analysis
- Genes, Insect
- Host-Parasite Interactions
- Longevity
- Phenotype
- Transcriptome
- Sprache
- eng
- Country
- England
- Paginierung
- 648 - 660
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Gene expression patterns underlying parasite-induced alterations in host behaviour and life history.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 25
Data source: PubMed
- Beziehungen:
- Property of