Cost evaluation of PAGE-B risk score guided HCC surveillance in patients with treated chronic hepatitis B

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The PAGE-B score (Platelet Age GEnder–HBV) selects chronic hepatitis B (cHB) patients showing no relevant 5-year risk for hepatocellular carcinoma (HCC). We, therefore, explored potential cost reduction following the introduction of a PAGE-B tailored ultrasound screening in a single center cohort of cHB patients receiving stable antiviral therapy.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>cHB patients attending throughout the year 2018 were documented. Patients eligible for PAGE-B score were classified into high (≥18 points), intermediate (10–17 points) and low (≤9 points) HCC risk groups. Patients of the low HCC risk group could postpone HCC screening to reduce HCC screening expenses. Full costs for hepatic ultrasound were assessed.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Throughout the year cHB patients (<jats:italic>n</jats:italic> = 607) attended our clinic, which included PAGE-B eligible patients (<jats:italic>n</jats:italic> = 227, 37.4%) of whom <jats:italic>n</jats:italic> = 94 (15.8%) were allocated to the low HCC risk group. Sonographic HCC screening during a median exam time of 12.4 min (IQR 9.2–17.2) resulted in total costs of 22.82 Euro/exam. Additional opportunistic expenses caused by patient’s lost earnings or productivity were 15.6–17.5 €/exam and 26.7 €/exam, respectively. Following a PAGE-B tailored HCC screening at our institution annual full costs for cHB patients could be reduced by 15.51%, which equals a cost reduction by 1.91% for our total sonography unit. In comparison, 1.35% up to 7.65% of HBV-infected patients of Caucasian descent could postpone HCC screening according to population-based estimates from Germany.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>PAGE-B risk score adapted screening for HCC is an efficient and cost neutral tool to reduce costs for sonography in Caucasian patients with chronic hepatitis B receiving antiviral treatment.</jats:p> </jats:sec>
Autoren
  • Martin F Sprinzl
  • Christina Feist
  • Sandra Koch
  • Wolfgang M Kremer
  • Karl J Lackner
  • Arndt Weinmann
  • Peter R Galle
DOI
10.1186/s12913-021-06794-6
eISSN
1472-6963
Ausgabe der Veröffentlichung
1
Zeitschrift
BMC Health Services Research
Sprache
en
Artikelnummer
846
Online publication date
2021
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1186/s12913-021-06794-6
Datum der Datenerfassung
2021
Titel
Cost evaluation of PAGE-B risk score guided HCC surveillance in patients with treated chronic hepatitis B
Ausgabe der Zeitschrift
21

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Martin F Sprinzl
  • Christina Feist
  • Sandra Koch
  • Wolfgang Maximilian Kremer
  • Karl J Lackner
  • Arndt Weinmann
  • Peter R Galle
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1186/s12913-021-06794-6
File(s) embargoed
false
Open access
true
ISSN
1472-6963
Zeitschrift
BMC health services research
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
846
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7281
Herausgeber
BioMed Central
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Cost evaluation of PAGE-B risk score guided HCC surveillance in patients with treated chronic hepatitis B
Ausgabe der Zeitschrift
21

Files

cost_evaluation_of_pageb_risk-20220630121855371.pdf

Data source: OPENSCIENCE.UB

Tools