Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries

Publication type:
Journal article
Metadata:
Autoren
  • Di He
  • Yafei Ren
  • Xin Hua
  • Jiao Zhang
  • Bin Zhang
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:001153084100001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2022.154196
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: VN4UB
  • PubMed Identifier: 35667259
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Edible fungus
  • Functional food
  • Pathophysiology
  • Phytochemistry
  • Phytotherapy
  • Mechanism of action
Artikelnummer
ARTN 154196
Datum der Veröffentlichung
2022
Status
Published
Titel
Phytochemistry and bioactivities of the main constituents of <i>Polyporus umbellatus</i> (Pers.) Fries
Sub types
  • Article
Ausgabe der Zeitschrift
103

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Di He
  • Yafei Ren
  • Xin Hua
  • Jiao Zhang
  • Bin Zhang
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
DOI
10.1016/j.phymed.2022.154196
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
154196
Paginierung
154196 - 154196
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2022.154196
Datum der Datenerfassung
2024
Titel
Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries
Ausgabe der Zeitschrift
103

Data source: Crossref

Abstract
<h4>Background</h4>Edible fungi resources have good application prospects in the research and development of food, medicine, and health products. Polyporus umbellatus (Pers.) Fries, as a precious edible and medicinal fungus, has long been used by Chinese medicine to treat urinary systems and related kidney diseases.<h4>Purpose</h4>In recent years, researchers have discovered and isolated a variety of active compounds from P. umbellatus. Modern phytochemical and pharmacological experiments showed that the crude extract of P. umbellatus had many biological functions and could be widely used in the fields of food, pharmaceutical and cosmetics. This paper summarizes the active components of P. umbellatus, through elaborating its mechanism of action, further clarify the action substances, in order to improve the utilization rate of P. umbellatus, promote the development and application of P. umbellatus in food, pharmaceutical and cosmetics industry.<h4>Methods</h4>In this paper, the literatures related to P. umbellatus were summarized and classified by "China National Knowledge Instructure (CNKI)", "Google Scholar" and "Web of Science". Compared with other articles, this work systematically sorted out all the active substances with clear structures in P. umbellatus. On this basis, combined with the chemical composition of P. umbellatus, its functional efficacy was expounded, and the effects of different types of active substances in P. umbellatus were further presented.<h4>Results</h4>The main chemical constituents of P. umbellatus include polysaccharide and sterol, and the secondary compounds include fatty acids, phenols and other small molecules. These active substances endowed P. umbellatus anti-cancer, antibacterial, diuretic, antioxidant, enhance immune system, promote hair growth and other pharmacological activities, which has been verified many times in vivo and in vitro experiments.<h4>Conclusion</h4>Modern in vitro or in vivo pharmacological experiments and clinical practice for the efficacy of P. umbellatus provides a strong support, and the separation of compounds in P. umbellatus has also deepened people's understanding of this traditional Chinese medicine, greatly promoted the development and application of P. umbellatus. However, the complex active substances of poring also hinder the research of P. umbellatus to some extent, and the mechanism of action and potential synergistic or antagonistic effect of the mixture of various active ingredients have not been clearly analyzed. How to use the bioactivity-guided separation strategy to identify more bioactive components and analyze the molecular mechanism of the main active components have become the main problems of P. umbellatus research, but also provides a direction for the further study of it.
Addresses
  • College of Life Sciences, Northwest A&F University, No.22 Xinong Road, Yangling, Shaanxi 712100, China.
Autoren
  • Di He
  • Yafei Ren
  • Xin Hua
  • Jiao Zhang
  • Bin Zhang
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
DOI
10.1016/j.phymed.2022.154196
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 35667259
Funding acknowledgements
  • National Key Research and Development Program of China: 2021YFD1000203
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Diuretics
  • Pharmaceutical Preparations
  • Medicine, Chinese Traditional
  • Ethnopharmacology
  • Polyporus
  • Phytochemicals
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Paginierung
154196
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
103

Data source: Europe PubMed Central

Abstract
BACKGROUND: Edible fungi resources have good application prospects in the research and development of food, medicine, and health products. Polyporus umbellatus (Pers.) Fries, as a precious edible and medicinal fungus, has long been used by Chinese medicine to treat urinary systems and related kidney diseases. PURPOSE: In recent years, researchers have discovered and isolated a variety of active compounds from P. umbellatus. Modern phytochemical and pharmacological experiments showed that the crude extract of P. umbellatus had many biological functions and could be widely used in the fields of food, pharmaceutical and cosmetics. This paper summarizes the active components of P. umbellatus, through elaborating its mechanism of action, further clarify the action substances, in order to improve the utilization rate of P. umbellatus, promote the development and application of P. umbellatus in food, pharmaceutical and cosmetics industry. METHODS: In this paper, the literatures related to P. umbellatus were summarized and classified by "China National Knowledge Instructure (CNKI)", "Google Scholar" and "Web of Science". Compared with other articles, this work systematically sorted out all the active substances with clear structures in P. umbellatus. On this basis, combined with the chemical composition of P. umbellatus, its functional efficacy was expounded, and the effects of different types of active substances in P. umbellatus were further presented. RESULTS: The main chemical constituents of P. umbellatus include polysaccharide and sterol, and the secondary compounds include fatty acids, phenols and other small molecules. These active substances endowed P. umbellatus anti-cancer, antibacterial, diuretic, antioxidant, enhance immune system, promote hair growth and other pharmacological activities, which has been verified many times in vivo and in vitro experiments. CONCLUSION: Modern in vitro or in vivo pharmacological experiments and clinical practice for the efficacy of P. umbellatus provides a strong support, and the separation of compounds in P. umbellatus has also deepened people's understanding of this traditional Chinese medicine, greatly promoted the development and application of P. umbellatus. However, the complex active substances of poring also hinder the research of P. umbellatus to some extent, and the mechanism of action and potential synergistic or antagonistic effect of the mixture of various active ingredients have not been clearly analyzed. How to use the bioactivity-guided separation strategy to identify more bioactive components and analyze the molecular mechanism of the main active components have become the main problems of P. umbellatus research, but also provides a direction for the further study of it.
Date of acceptance
2022
Autoren
  • Di He
  • Yafei Ren
  • Xin Hua
  • Jiao Zhang
  • Bin Zhang
  • Juane Dong
  • Thomas Efferth
  • Pengda Ma
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35667259
DOI
10.1016/j.phymed.2022.154196
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Edible fungus
  • Functional food
  • Mechanism of action
  • Pathophysiology
  • Phytochemistry
  • Phytotherapy
  • Diuretics
  • Ethnopharmacology
  • Humans
  • Medicine, Chinese Traditional
  • Pharmaceutical Preparations
  • Phytochemicals
  • Polyporus
Sprache
eng
Country
Germany
Paginierung
154196
PII
S0944-7113(22)00274-4
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
103

Data source: PubMed

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