Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Olesya Vakhrusheva
- Holger HH Erb
- Vitus Braeunig
- Sascha D Markowitsch
- Patricia Schupp
- Patrick C Baer
- Kimberly Sue Slade
- Anita Thomas
- Igor Tsaur
- Martin Puhr
- Zoran Culig
- Jindrich Cinatl
- Martin Michaelis
- Thomas Efferth
- Axel Haferkamp
- Eva Juengel
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000760996500001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3389/fonc.2022.789284
- Externe Identifier
- Clarivate Analytics Document Solution ID: ZH5RS
- PubMed Identifier: 35198441
- ISSN
- 2234-943X
- Zeitschrift
- FRONTIERS IN ONCOLOGY
- Schlüsselwörter
- prostate cancer (PCa)
- docetaxel (DX) resistance
- artesunate (ART)
- Traditional Chinese Medicine (TCM)
- growth inhibition
- apoptosis
- ferroptosis
- Artikelnummer
- ARTN 789284
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 12
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to exhibit tumor suppressive properties. Therefore, the therapeutic potential of artesunate (ART) on the progressive growth of therapy-sensitive (parental) and docetaxel (DX)-resistant PCa cells was investigated. Parental and DX-resistant PCa cell lines DU145, PC3, and LNCaP were incubated with artesunate (ART) [1-100 µM]. ART-untreated and ‘non-cancerous’ cells served as controls. Cell growth, proliferation, cell cycle progression, cell death and the expression of involved proteins were evaluated. ART, dose- and time-dependently, significantly restricted cell growth and proliferation of parental and DX-resistant PCa cells, but not of ‘normal, non-cancerous’ cells. ART-induced growth and proliferation inhibition was accompanied by G0/G1 phase arrest and down-regulation of cell cycle activating proteins in all DX-resistant PCa cells and parental LNCaP. In the parental and DX-resistant PC3 and LNCaP cell lines, ART also promoted apoptotic cell death. Ferroptosis was exclusively induced by ART in parental and DX-resistant DU145 cells by increasing reactive oxygen species (ROS). The anti-cancer activity displayed by ART took effect in all three PCa cell lines, but through different mechanisms of action. Thus, in advanced PCa, ART may hold promise as a complementary treatment together with conventional therapy.</jats:p>
- Autoren
- Olesya Vakhrusheva
- Holger HH Erb
- Vitus Bräunig
- Sascha D Markowitsch
- Patricia Schupp
- Patrick C Baer
- Kimberly Sue Slade
- Anita Thomas
- Igor Tsaur
- Martin Puhr
- Zoran Culig
- Jindrich Cinatl
- Martin Michaelis
- Thomas Efferth
- Axel Haferkamp
- Eva Juengel
- DOI
- 10.3389/fonc.2022.789284
- eISSN
- 2234-943X
- Zeitschrift
- Frontiers in Oncology
- Online publication date
- 2022
- Status
- Published online
- Herausgeber
- Frontiers Media SA
- Herausgeber URL
- http://dx.doi.org/10.3389/fonc.2022.789284
- Datum der Datenerfassung
- 2022
- Titel
- Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells
- Ausgabe der Zeitschrift
- 12
Data source: Crossref
- Abstract
- Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to exhibit tumor suppressive properties. Therefore, the therapeutic potential of artesunate (ART) on the progressive growth of therapy-sensitive (parental) and docetaxel (DX)-resistant PCa cells was investigated. Parental and DX-resistant PCa cell lines DU145, PC3, and LNCaP were incubated with artesunate (ART) [1-100 µM]. ART-untreated and 'non-cancerous' cells served as controls. Cell growth, proliferation, cell cycle progression, cell death and the expression of involved proteins were evaluated. ART, dose- and time-dependently, significantly restricted cell growth and proliferation of parental and DX-resistant PCa cells, but not of 'normal, non-cancerous' cells. ART-induced growth and proliferation inhibition was accompanied by G0/G1 phase arrest and down-regulation of cell cycle activating proteins in all DX-resistant PCa cells and parental LNCaP. In the parental and DX-resistant PC3 and LNCaP cell lines, ART also promoted apoptotic cell death. Ferroptosis was exclusively induced by ART in parental and DX-resistant DU145 cells by increasing reactive oxygen species (ROS). The anti-cancer activity displayed by ART took effect in all three PCa cell lines, but through different mechanisms of action. Thus, in advanced PCa, ART may hold promise as a complementary treatment together with conventional therapy.
- Addresses
- Department of Urology and Pediatric Urology, University Medical Center Mainz, Mainz, Germany.
- Autoren
- Olesya Vakhrusheva
- Holger HH Erb
- Vitus Bräunig
- Sascha D Markowitsch
- Patricia Schupp
- Patrick C Baer
- Kimberly Sue Slade
- Anita Thomas
- Igor Tsaur
- Martin Puhr
- Zoran Culig
- Jindrich Cinatl
- Martin Michaelis
- Thomas Efferth
- Axel Haferkamp
- Eva Juengel
- DOI
- 10.3389/fonc.2022.789284
- eISSN
- 2234-943X
- Externe Identifier
- PubMed Identifier: 35198441
- PubMed Central ID: PMC8859178
- Open access
- true
- ISSN
- 2234-943X
- Zeitschrift
- Frontiers in oncology
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 789284
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 12
Files
https://www.frontiersin.org/articles/10.3389/fonc.2022.789284/pdf https://europepmc.org/articles/PMC8859178?pdf=render
Data source: Europe PubMed Central
- Abstract
- Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to exhibit tumor suppressive properties. Therefore, the therapeutic potential of artesunate (ART) on the progressive growth of therapy-sensitive (parental) and docetaxel (DX)-resistant PCa cells was investigated. Parental and DX-resistant PCa cell lines DU145, PC3, and LNCaP were incubated with artesunate (ART) [1-100 µM]. ART-untreated and 'non-cancerous' cells served as controls. Cell growth, proliferation, cell cycle progression, cell death and the expression of involved proteins were evaluated. ART, dose- and time-dependently, significantly restricted cell growth and proliferation of parental and DX-resistant PCa cells, but not of 'normal, non-cancerous' cells. ART-induced growth and proliferation inhibition was accompanied by G0/G1 phase arrest and down-regulation of cell cycle activating proteins in all DX-resistant PCa cells and parental LNCaP. In the parental and DX-resistant PC3 and LNCaP cell lines, ART also promoted apoptotic cell death. Ferroptosis was exclusively induced by ART in parental and DX-resistant DU145 cells by increasing reactive oxygen species (ROS). The anti-cancer activity displayed by ART took effect in all three PCa cell lines, but through different mechanisms of action. Thus, in advanced PCa, ART may hold promise as a complementary treatment together with conventional therapy.
- Date of acceptance
- 2022
- Autoren
- Olesya Vakhrusheva
- Holger HH Erb
- Vitus Bräunig
- Sascha D Markowitsch
- Patricia Schupp
- Patrick C Baer
- Kimberly Sue Slade
- Anita Thomas
- Igor Tsaur
- Martin Puhr
- Zoran Culig
- Jindrich Cinatl
- Martin Michaelis
- Thomas Efferth
- Axel Haferkamp
- Eva Juengel
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35198441
- DOI
- 10.3389/fonc.2022.789284
- Externe Identifier
- PubMed Central ID: PMC8859178
- ISSN
- 2234-943X
- Zeitschrift
- Front Oncol
- Schlüsselwörter
- Traditional Chinese Medicine (TCM)
- apoptosis
- artesunate (ART)
- docetaxel (DX) resistance
- ferroptosis
- growth inhibition
- prostate cancer (PCa)
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 789284
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Titel
- Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 12
Data source: PubMed
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