Antimicrobial activity and cytotoxicity towards cancer cells of Melaleuca alternifolia (tea tree) oil
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Xia Liu
- Yuangang Zu
- Yujie Fu
- Liping Yao
- Chengbo Gu
- Wei Wang
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000266261400008&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1007/s00217-009-1057-5
- eISSN
- 1438-2385
- Externe Identifier
- Clarivate Analytics Document Solution ID: 448KL
- ISSN
- 1438-2377
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- EUROPEAN FOOD RESEARCH AND TECHNOLOGY
- Schlüsselwörter
- Antimicrobial activity
- Cell cycle
- Cytotoxicity to tumor cells
- Melaleuca alternifolia (Myrtaceae)
- Tea tree oil
- Paginierung
- 247 - 253
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Titel
- Antimicrobial activity and cytotoxicity towards cancer cells of <i>Melaleuca alternifolia</i> (tea tree) oil
- Sub types
- Article
- Ausgabe der Zeitschrift
- 229
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Xia Liu
- Yuangang Zu
- Yujie Fu
- Liping Yao
- Chengbo Gu
- Wei Wang
- Thomas Efferth
- DOI
- 10.1007/s00217-009-1057-5
- eISSN
- 1438-2385
- ISSN
- 1438-2377
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- European Food Research and Technology
- Sprache
- en
- Online publication date
- 2009
- Paginierung
- 247 - 253
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s00217-009-1057-5
- Datum der Datenerfassung
- 2020
- Titel
- Antimicrobial activity and cytotoxicity towards cancer cells of Melaleuca alternifolia (tea tree) oil
- Ausgabe der Zeitschrift
- 229
Data source: Crossref
- Abstract
- Antimicrobial and in vitro anti-tumor activities of Melaleuca alternifolia (tea tree) oil (TTO) were analyzed. The results indicated that TTO possessed significant antimicrobial activity towards all tested microorganisms except Aspergillus niger. The minimum inhibitory concentration (MIC) of TTO towards Staphylococcus epidermidi, Bacillus subtilis, Escherichia coli and Candida albicans was 0.25% (v/v). Time kinetic experiments showed that Staphylococcus epidermidi, Escherichia coli and Candida albicans were completely killed after exposure to TTO at 2x MIC for 1, 4 and 8 h, repectively. TTO also exhibited strong cytotoxicity towards human lung cancer cell line (A549), human breast cancer cell line (MCF-7) and human prostate cancer cell line (PC-3). The IC₅₀ values obtained were 0.012% (v/v), 0.031% (v/v) and 0.037% (v/v), respectively. Flow cytometric analysis demonstrated that TTO restrained the cell cycle progression of PC-3 and MCF-7 cell lines at the G0/G1 phase and A549 cell at the S phase.
- Autoren
- Xia Liu
- Yuangang Zu
- Yujie Fu
- Liping Yao
- Chengbo Gu
- Wei Wang
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1007/s00217-009-1057-5
- Open access
- false
- ISSN
- 1438-2377
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- European food research and technology = Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. A
- Sprache
- eng
- Medium
- Undetermined
- Paginierung
- 247 - 253
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Datum der Datenerfassung
- 2009
- Titel
- Antimicrobial activity and cytotoxicity towards cancer cells of Melaleuca alternifolia (tea tree) oil
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 229
Data source: Europe PubMed Central
- Beziehungen:
- Property of