Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing apigenin from pigeon pea [Cajanus cajan (L.) Millsp.]

Publication type:
Journal article
Metadata:
Autoren
  • Yuan Gao
  • Jintong Zhao
  • Yuangang Zu
  • Yujie Fu
  • Lu Liang
  • Meng Luo
  • Wei Wang
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000311592500022&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.foodres.2012.08.001
eISSN
1873-7145
Externe Identifier
  • Clarivate Analytics Document Solution ID: 044AT
ISSN
0963-9969
Ausgabe der Veröffentlichung
1
Zeitschrift
FOOD RESEARCH INTERNATIONAL
Schlüsselwörter
  • Endophyte
  • Antioxidant
  • Apigenin
  • Superoxide dismutase
  • Glutathione reductase
Paginierung
147 - 152
Datum der Veröffentlichung
2012
Status
Published
Titel
Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing apigenin from pigeon pea [<i>Cajanus cajan</i> (L.) Millsp.]
Sub types
  • Article
Ausgabe der Zeitschrift
49

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Yuan Gao
  • Jintong Zhao
  • Yuangang Zu
  • Yujie Fu
  • Lu Liang
  • Meng Luo
  • Wei Wang
  • Thomas Efferth
DOI
10.1016/j.foodres.2012.08.001
ISSN
0963-9969
Ausgabe der Veröffentlichung
1
Zeitschrift
Food Research International
Sprache
en
Paginierung
147 - 152
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.foodres.2012.08.001
Datum der Datenerfassung
2022
Titel
Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing apigenin from pigeon pea [Cajanus cajan (L.) Millsp.]
Ausgabe der Zeitschrift
49

Data source: Crossref

Abstract
A fungal endophyte MD89 with obvious antioxidant activities was isolated from pigeon pea and identified as Chaetomium globosum by ITS sequence. Different fractions from MD89 culture were compared and evaluated by total phenol (TP) content, total flavonoid (TFL) content, DPPH radical scavenging, reducing power and lipid peroxidation assays, respectively. Results showed that EtOAc extracts had high content of TP and TFL, and strong antioxidant activities (IC₅₀ value was 6.87, 15.19, 16.78μg/mL, respectively). Furthermore, the EtOAc extracts were analyzed by LC–MS/MS and a good antioxidant compound, apigenin, was found. The activities of superoxide dismutase (SOD) and glutathione reductase (GR) in HepG2 cells treated with MD89 EtOAc extracts were also determined. It is revealed that EtOAc extracts increased the activities of SOD and GR in HepG2 cells significantly in a dose-dependent manner. On the basis of those results, we conclude that MD89 represents a valuable natural antioxidant source and may be applicable in health food industry potentially.
Autoren
  • Yuan Gao
  • Jintong Zhao
  • Yuangang Zu
  • Yujie Fu
  • Lu Liang
  • Meng Luo
  • Wei Wang
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1016/j.foodres.2012.08.001
eISSN
1873-7145
Funding acknowledgements
  • Program for Importation of International Advanced Forestry Science and Technology, National Forestry Bureau: 2012406
  • Heilongjiang Province Science Foundation for Excellent Youths: JC200704
  • Special Fund of Forestry Industrial Research for Public Welfare of China: 201004040
  • Project for Distinguished Teacher Abroad, Chinese Ministry of Education: MS2010DBLY031
Open access
false
ISSN
0963-9969
Ausgabe der Veröffentlichung
1
Zeitschrift
Food research international (Ottawa, Ont.)
Sprache
eng
Medium
Undetermined
Paginierung
147 - 152
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2014
Titel
Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing apigenin from pigeon pea [Cajanus cajan (L.) Millsp.]
Sub types
  • Journal Article
Ausgabe der Zeitschrift
49

Data source: Europe PubMed Central

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