Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines

Publication type:
Journal article
Metadata:
Autoren
  • Sophia Yui Kau Fong
  • Thomas H Efferth
  • Zhong Zuo
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000345213200008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1517/17425255.2014.970167
eISSN
1744-7607
Externe Identifier
  • Clarivate Analytics Document Solution ID: AT8XU
  • PubMed Identifier: 25307559
ISSN
1742-5255
Ausgabe der Veröffentlichung
12
Zeitschrift
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
Schlüsselwörter
  • adverse effects
  • Chinese herbal medicines
  • gastrointestinal ulcer
  • herb-drug interaction
  • NSAIDs
Paginierung
1711 - 1739
Datum der Veröffentlichung
2014
Status
Published
Titel
Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines
Sub types
  • Review
Ausgabe der Zeitschrift
10

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Sophia Yui Kau Fong
  • Thomas H Efferth
  • Zhong Zuo
DOI
10.1517/17425255.2014.970167
eISSN
1744-7607
ISSN
1742-5255
Ausgabe der Veröffentlichung
12
Zeitschrift
Expert Opinion on Drug Metabolism & Toxicology
Sprache
en
Online publication date
2014
Paginierung
1711 - 1739
Datum der Veröffentlichung
2014
Status
Published
Herausgeber
Informa UK Limited
Herausgeber URL
http://dx.doi.org/10.1517/17425255.2014.970167
Datum der Datenerfassung
2022
Titel
Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines
Ausgabe der Zeitschrift
10

Data source: Crossref

Abstract
<h4>Introduction</h4>Concomitant use of NSAIDs and Chinese herbal medicines (CHMs) is frequent, yet summarized information on their interactions is lacking.<h4>Areas covered</h4>A systematic review of literature in four evidence-based English databases was performed. Articles which reported CHMs altering the pharmacokinetics, therapeutic and adverse effects of NSAIDs were identified and summarized. Such interactions may lead to beneficial, detrimental or no change in outcomes. The current review covers four therapeutic effects of NSAIDs, including: i) anti-inflammatory; ii) analgesic; iii) antiplatelet, cardiovascular and cerebrovascular; and iv) anticancer effects and four adverse effects of NSAIDs, including: i) gastrointestinal ulcer; ii) nephrotoxicity; iii) hepatotoxicity; and iv) antiplatelet effects and bleeding.<h4>Expert opinion</h4>While majority of CHMs demonstrated effectiveness in alleviating NSAIDs-induced adverse effects and potentiating the therapeutic effects, this review provides insights for development of CHMs as add-on medications to NSAIDs therapies. However, since limited information was from well-designed clinical trials, the findings are not yet conclusive and more clinical studies are warranted to provide guidance for healthcare professionals. In future, researches on interactions between NSAIDs and CHMs are expected to grow and modern approaches such as pharmacogenomics might enhance the throughput and accuracy of identifying clinically relevant interactions.
Addresses
  • The Chinese University of Hong Kong, School of Pharmacy, Faculty of Medicine , Shatin, New Territories , Hong Kong SAR.
Autoren
DOI
10.1517/17425255.2014.970167
eISSN
1744-7607
Externe Identifier
  • PubMed Identifier: 25307559
Open access
false
ISSN
1742-5255
Ausgabe der Veröffentlichung
12
Zeitschrift
Expert opinion on drug metabolism & toxicology
Schlüsselwörter
  • Animals
  • Humans
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
  • Risk Assessment
  • Herb-Drug Interactions
Sprache
eng
Medium
Print-Electronic
Online publication date
2014
Paginierung
1711 - 1739
Datum der Veröffentlichung
2014
Status
Published
Datum der Datenerfassung
2014
Titel
Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines.
Sub types
  • Research Support, Non-U.S. Gov't
  • Systematic Review
  • Review
  • Journal Article
Ausgabe der Zeitschrift
10

Data source: Europe PubMed Central

Abstract
INTRODUCTION: Concomitant use of NSAIDs and Chinese herbal medicines (CHMs) is frequent, yet summarized information on their interactions is lacking. AREAS COVERED: A systematic review of literature in four evidence-based English databases was performed. Articles which reported CHMs altering the pharmacokinetics, therapeutic and adverse effects of NSAIDs were identified and summarized. Such interactions may lead to beneficial, detrimental or no change in outcomes. The current review covers four therapeutic effects of NSAIDs, including: i) anti-inflammatory; ii) analgesic; iii) antiplatelet, cardiovascular and cerebrovascular; and iv) anticancer effects and four adverse effects of NSAIDs, including: i) gastrointestinal ulcer; ii) nephrotoxicity; iii) hepatotoxicity; and iv) antiplatelet effects and bleeding. EXPERT OPINION: While majority of CHMs demonstrated effectiveness in alleviating NSAIDs-induced adverse effects and potentiating the therapeutic effects, this review provides insights for development of CHMs as add-on medications to NSAIDs therapies. However, since limited information was from well-designed clinical trials, the findings are not yet conclusive and more clinical studies are warranted to provide guidance for healthcare professionals. In future, researches on interactions between NSAIDs and CHMs are expected to grow and modern approaches such as pharmacogenomics might enhance the throughput and accuracy of identifying clinically relevant interactions.
Autoren
  • Sophia Yui Kau Fong
  • Thomas H Efferth
  • Zhong Zuo
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/25307559
DOI
10.1517/17425255.2014.970167
eISSN
1744-7607
Ausgabe der Veröffentlichung
12
Zeitschrift
Expert Opin Drug Metab Toxicol
Schlüsselwörter
  • Chinese herbal medicines
  • NSAIDs
  • adverse effects
  • gastrointestinal ulcer
  • herb–drug interaction
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
  • Herb-Drug Interactions
  • Humans
  • Risk Assessment
Sprache
eng
Country
England
Paginierung
1711 - 1739
Datum der Veröffentlichung
2014
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review
Ausgabe der Zeitschrift
10

Data source: PubMed

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