Cytotoxic and chemotaxonomic study of isolated metabolites fromCentaurea aegyptiaca

Publication type:
Journal article
Metadata:
Autoren
  • Tarik A Mohamed
  • Abdelsamed I Elshamy
  • Ahmed M Abd-ElGawad
  • Taha A Hussien
  • Sayed A El-Toumy
  • Thomas Efferth
  • Mohamed-Elamir F Hegazy
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000571317900001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/jccs.202000156
eISSN
2192-6549
Externe Identifier
  • Clarivate Analytics Document Solution ID: QD0RO
ISSN
0009-4536
Ausgabe der Veröffentlichung
1
Zeitschrift
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
Schlüsselwörter
  • Centaurea aegyptiaca
  • chemosystematic significance
  • cytotoxicity
  • lignans
  • monoterpene
  • sesquiterpene lactones
Paginierung
159 - 168
Datum der Veröffentlichung
2021
Status
Published
Titel
Cytotoxic and chemotaxonomic study of isolated metabolites from<i>Centaurea aegyptiaca</i>
Sub types
  • Article
Ausgabe der Zeitschrift
68

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>The aerial parts of <jats:italic>Centaureaa egyptiaca</jats:italic> afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) (<jats:bold>1</jats:bold>), rediolpidetriol (<jats:bold>2</jats:bold>), linichlorinA (<jats:bold>3</jats:bold>), and sinaicin (<jats:bold>4</jats:bold>), one monoterpene; loliolid (<jats:bold>5</jats:bold>), one phenolic: tyrosol (<jats:bold>6</jats:bold>), three lignans; arctigenin (<jats:bold>7</jats:bold>), matairesinol (<jats:bold>8</jats:bold>), and pinoresinol (<jats:bold>9</jats:bold>), and one steroid; ergosta‐5,22‐dien‐3‐ol (<jats:bold>10</jats:bold>). The cluster analysis of 32 <jats:italic>Centaurea</jats:italic> species revealed that <jats:italic>C. aegyptiaca</jats:italic> is closely related to <jats:italic>C. repens</jats:italic> and <jats:italic>C. solstitialise</jats:italic>. The isolated compounds (<jats:bold>1</jats:bold>–<jats:bold>10</jats:bold>) were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53<jats:sup>+</jats:sup>/<jats:sup>+</jats:sup>) colon carcinoma cell lines. Compounds<jats:bold>1</jats:bold> and <jats:bold>2</jats:bold> were the most potent compounds against both leukemia and breast carcinoma cell lines.</jats:p>
Autoren
  • Tarik A Mohamed
  • Abdelsamed I Elshamy
  • Ahmed M Abd‐ElGawad
  • Taha A Hussien
  • Sayed A El‐Toumy
  • Thomas Efferth
  • Mohamed‐Elamir F Hegazy
DOI
10.1002/jccs.202000156
eISSN
2192-6549
ISSN
0009-4536
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of the Chinese Chemical Society
Sprache
en
Online publication date
2020
Paginierung
159 - 168
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/jccs.202000156
Datum der Datenerfassung
2023
Titel
Cytotoxic and chemotaxonomic study of isolated metabolites from <i>Centaurea aegyptiaca</i>
Ausgabe der Zeitschrift
68

Data source: Crossref

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