DETECTION OF MURINE S180 CELLS EXPRESSING A MULTIDRUG RESISTANCE PHENOTYPE USING DIFFERENT INVITRO TEST SYSTEMS AND A MONOCLONAL-ANTIBODY

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1987J253200029&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: J2532
  • PubMed Identifier: 3314882
ISSN
0004-4172
Ausgabe der Veröffentlichung
7
Zeitschrift
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
Paginierung
862 - 867
Datum der Veröffentlichung
1987
Status
Published
Titel
DETECTION OF MURINE S180 CELLS EXPRESSING A MULTIDRUG RESISTANCE PHENOTYPE USING DIFFERENT INVITRO TEST SYSTEMS AND A MONOCLONAL-ANTIBODY
Sub types
  • Article
Ausgabe der Zeitschrift
37-2

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
Doxorubicin (adriamycin) preconditioned S180 cells were more resistant to doxorubicin. The resistance was detected by three different methods (short-term test, colony assay, tissue culture assay). The doxorubicin-resistant S180 cells express the pleitrop drug resistance phenotype. There exists a multidrug resistance to doxorubicin, dactinomycin (actinomycin D), vincristine and colchicine. In addition, collateral sensitivity was found to fluorouracil (5-fluorouracil) and methotrexate. This multidrug phenotype is in accordance with the pleiotropic phenotype of colchicine-resistant CHO cells. Resistant S180 cells express a glycoprotein of Mr 170 kd determined by indirect immunofluorescence using a monoclonal antibody (Mab 265/F4) to the P-glycoprotein of colchicine-resistant CHO-cells. The P-glycoprotein could be an important prognostic factors for tumors with multidrug resistance.
Addresses
  • Institute of Experimental Pathology, German Cancer Research Center, Heidelberg.
Autoren
eISSN
1616-7066
Externe Identifier
  • PubMed Identifier: 3314882
Open access
false
ISSN
0004-4172
Ausgabe der Veröffentlichung
7
Zeitschrift
Arzneimittel-Forschung
Schlüsselwörter
  • Cell Line
  • Animals
  • Mice
  • Antineoplastic Agents
  • Antibodies, Monoclonal
  • Microscopy, Fluorescence
  • Fluorescent Antibody Technique
  • Drug Resistance
  • Phenotype
Sprache
eng
Medium
Print
Paginierung
862 - 867
Datum der Veröffentlichung
1987
Status
Published
Datum der Datenerfassung
1987
Titel
Detection of murine S180 cells expressing a multidrug resistance phenotype using different in vitro test systems and a monoclonal antibody.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
37

Data source: Europe PubMed Central

Abstract
Doxorubicin (adriamycin) preconditioned S180 cells were more resistant to doxorubicin. The resistance was detected by three different methods (short-term test, colony assay, tissue culture assay). The doxorubicin-resistant S180 cells express the pleitrop drug resistance phenotype. There exists a multidrug resistance to doxorubicin, dactinomycin (actinomycin D), vincristine and colchicine. In addition, collateral sensitivity was found to fluorouracil (5-fluorouracil) and methotrexate. This multidrug phenotype is in accordance with the pleiotropic phenotype of colchicine-resistant CHO cells. Resistant S180 cells express a glycoprotein of Mr 170 kd determined by indirect immunofluorescence using a monoclonal antibody (Mab 265/F4) to the P-glycoprotein of colchicine-resistant CHO-cells. The P-glycoprotein could be an important prognostic factors for tumors with multidrug resistance.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/3314882
ISSN
0004-4172
Ausgabe der Veröffentlichung
7
Zeitschrift
Arzneimittelforschung
Schlüsselwörter
  • Animals
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Cell Line
  • Drug Resistance
  • Fluorescent Antibody Technique
  • Mice
  • Microscopy, Fluorescence
  • Phenotype
Sprache
eng
Country
Germany
Paginierung
862 - 867
Datum der Veröffentlichung
1987
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1987
Titel
Detection of murine S180 cells expressing a multidrug resistance phenotype using different in vitro test systems and a monoclonal antibody.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
37

Data source: PubMed

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