IMMUNOCYTOCHEMICAL DETECTION OF A RESISTANCE-ASSOCIATED GLYCOPROTEIN IN TISSUE-CULTURE CELLS, ASCITES TUMORS AND HUMAN-TUMOR XENOGRAFTS BY MAB 265 F4

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1988Q417300002&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: Q4173
  • PubMed Identifier: 2902821
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
ANTICANCER RESEARCH
Paginierung
531 - 536
Datum der Veröffentlichung
1988
Status
Published
Titel
IMMUNOCYTOCHEMICAL DETECTION OF A RESISTANCE-ASSOCIATED GLYCOPROTEIN IN TISSUE-CULTURE CELLS, ASCITES TUMORS AND HUMAN-TUMOR XENOGRAFTS BY MAB 265 F4
Sub types
  • Article
Ausgabe der Zeitschrift
8

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
The aim of this investigation was to find out whether resistant cells of different tumors can be detected immunocytochemically by the streptavidin-biotin-peroxidase-complex method using the monoclonal antibody 265/F4. This antibody was prepared against the membrane P-glycoprotein of Mr 170 kd from colchicine-resistant CHO cells. For this purpose the acquired resistance of tissue culture cells, ascites tumors and the acquired and inherent resistance of human lung carcinoma xenografts were analyzed. Doxorubicin-resistant S180 cells, daunorubicin-resistant L1210 cells and vincristine-resistant human epidermoid lung carcinoma xenografts showed an intense positive reaction with the monoclonal antibody. In contrast, no specific immunoreactivity was observed with parental (sensitive) tumor cells. These data could eventually provide a prognostic tool for the detection of resistant human tumor cells.
Addresses
  • German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
Autoren
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 2902821
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
Anticancer research
Schlüsselwörter
  • Cell Line
  • Animals
  • Humans
  • Mice
  • Mice, Nude
  • Leukemia L1210
  • Sarcoma 180
  • Carcinoma, Squamous Cell
  • Lung Neoplasms
  • Vincristine
  • Daunorubicin
  • Doxorubicin
  • Membrane Glycoproteins
  • Antibodies, Monoclonal
  • Immunoenzyme Techniques
  • Transplantation, Heterologous
  • Neoplasm Transplantation
  • Drug Resistance
  • Female
  • Biomarkers, Tumor
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
531 - 535
Datum der Veröffentlichung
1988
Status
Published
Datum der Datenerfassung
1988
Titel
Immunocytochemical detection of a resistance-associated glycoprotein in tissue culture cells, ascites tumors and human tumor xenografts by Mab 265/F4.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
8

Data source: Europe PubMed Central

Abstract
The aim of this investigation was to find out whether resistant cells of different tumors can be detected immunocytochemically by the streptavidin-biotin-peroxidase-complex method using the monoclonal antibody 265/F4. This antibody was prepared against the membrane P-glycoprotein of Mr 170 kd from colchicine-resistant CHO cells. For this purpose the acquired resistance of tissue culture cells, ascites tumors and the acquired and inherent resistance of human lung carcinoma xenografts were analyzed. Doxorubicin-resistant S180 cells, daunorubicin-resistant L1210 cells and vincristine-resistant human epidermoid lung carcinoma xenografts showed an intense positive reaction with the monoclonal antibody. In contrast, no specific immunoreactivity was observed with parental (sensitive) tumor cells. These data could eventually provide a prognostic tool for the detection of resistant human tumor cells.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/2902821
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
Anticancer Res
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Animals
  • Antibodies, Monoclonal
  • Biomarkers, Tumor
  • Carcinoma, Squamous Cell
  • Cell Line
  • Daunorubicin
  • Doxorubicin
  • Drug Resistance
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Leukemia L1210
  • Lung Neoplasms
  • Membrane Glycoproteins
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Sarcoma 180
  • Transplantation, Heterologous
  • Vincristine
Sprache
eng
Country
Greece
Paginierung
531 - 535
Datum der Veröffentlichung
1988
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1988
Titel
Immunocytochemical detection of a resistance-associated glycoprotein in tissue culture cells, ascites tumors and human tumor xenografts by Mab 265/F4.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
8

Data source: PubMed

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