DETECTION OF DRUG-RESISTANCE IN HUMAN OVARIAN-CARCINOMA

Publication type:
Journal article
Metadata:
Autoren
  • M VOLM
  • T EFFERTH
  • M BAK
  • J MATTERN
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1989U082800009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/BF00931383
Externe Identifier
  • Clarivate Analytics Document Solution ID: U0828
  • PubMed Identifier: 2653233
ISSN
0932-0067
Ausgabe der Veröffentlichung
2
Zeitschrift
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Paginierung
123 - 128
Datum der Veröffentlichung
1989
Status
Published
Titel
DETECTION OF DRUG-RESISTANCE IN HUMAN OVARIAN-CARCINOMA
Sub types
  • Article
Ausgabe der Zeitschrift
244

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • M Volm
  • T Efferth
  • M Bak
  • J Mattern
DOI
10.1007/bf00931383
eISSN
1432-0711
ISSN
0932-0067
Ausgabe der Veröffentlichung
2
Zeitschrift
Archives of Gynecology and Obstetrics
Sprache
en
Paginierung
123 - 128
Datum der Veröffentlichung
1989
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/bf00931383
Datum der Datenerfassung
2021
Titel
Detection of drug resistance in human ovarian carcinoma
Ausgabe der Zeitschrift
244

Data source: Crossref

Abstract
Drug-resistant cancer cells with the multidrug-resistance phenotype show overexpression of P-glycoprotein, and we therefore tested carcinoma tissue from five patients with stage III or IV ovarian cancer for P-glycoprotein using 265/F4 and C 219 monoclonal antibodies, prepared against membrane glycoproteins in colchicine-resistant CHO cells. Using immunofluorescence and immunoblotting techniques, one of the tumors showed a positive reaction. Using the pcDR 1.5 clone we found that the same cancer tissue had elevated expression of the genes responsible for multidrug resistance. The demonstration of elevated P-glycoprotein in ovarian carcinomas indicates that P-glycoprotein overexpression is not limited to experimental tumor models.
Addresses
  • Department of Experimental Pathology, German Cancer Research Center, Heidelberg, FRG.
Autoren
DOI
10.1007/bf00931383
eISSN
1432-0711
Externe Identifier
  • PubMed Identifier: 2653233
Open access
false
ISSN
0932-0067
Ausgabe der Veröffentlichung
2
Zeitschrift
Archives of gynecology and obstetrics
Schlüsselwörter
  • Humans
  • Carcinoma
  • Ovarian Neoplasms
  • Glycoproteins
  • Fluorescent Antibody Technique
  • Immunoblotting
  • Drug Resistance
  • Female
Sprache
eng
Medium
Print
Paginierung
123 - 128
Datum der Veröffentlichung
1989
Status
Published
Datum der Datenerfassung
1989
Titel
Detection of drug resistance in human ovarian carcinoma.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
244

Data source: Europe PubMed Central

Abstract
Drug-resistant cancer cells with the multidrug-resistance phenotype show overexpression of P-glycoprotein, and we therefore tested carcinoma tissue from five patients with stage III or IV ovarian cancer for P-glycoprotein using 265/F4 and C 219 monoclonal antibodies, prepared against membrane glycoproteins in colchicine-resistant CHO cells. Using immunofluorescence and immunoblotting techniques, one of the tumors showed a positive reaction. Using the pcDR 1.5 clone we found that the same cancer tissue had elevated expression of the genes responsible for multidrug resistance. The demonstration of elevated P-glycoprotein in ovarian carcinomas indicates that P-glycoprotein overexpression is not limited to experimental tumor models.
Autoren
  • M Volm
  • T Efferth
  • M Bak
  • J Mattern
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/2653233
DOI
10.1007/BF00931383
ISSN
0932-0067
Ausgabe der Veröffentlichung
2
Zeitschrift
Arch Gynecol Obstet
Schlüsselwörter
  • Carcinoma
  • Drug Resistance
  • Female
  • Fluorescent Antibody Technique
  • Glycoproteins
  • Humans
  • Immunoblotting
  • Ovarian Neoplasms
Sprache
eng
Country
Germany
Paginierung
123 - 128
Datum der Veröffentlichung
1989
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1989
Titel
Detection of drug resistance in human ovarian carcinoma.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
244

Data source: PubMed

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