DETECTION OF P-GLYCOPROTEIN IN HUMAN LEUKEMIAS USING MONOCLONAL-ANTIBODIES

Publication type:
Journal article
Metadata:
Autoren
  • J MATTERN
  • T EFFERTH
  • M BAK
  • AD HO
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1989U139600008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/BF00320777
Externe Identifier
  • Clarivate Analytics Document Solution ID: U1396
  • PubMed Identifier: 2565123
ISSN
0006-5242
Ausgabe der Veröffentlichung
4
Zeitschrift
BLUT
Paginierung
215 - 217
Datum der Veröffentlichung
1989
Status
Published
Titel
DETECTION OF P-GLYCOPROTEIN IN HUMAN LEUKEMIAS USING MONOCLONAL-ANTIBODIES
Sub types
  • Note
Ausgabe der Zeitschrift
58

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • J Mattern
  • T Efferth
  • M Bak
  • AD Ho
  • M Volm
DOI
10.1007/bf00320777
eISSN
1432-0584
ISSN
0006-5242
Ausgabe der Veröffentlichung
4
Zeitschrift
Blut
Sprache
en
Paginierung
215 - 217
Datum der Veröffentlichung
1989
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/bf00320777
Datum der Datenerfassung
2020
Titel
Detection of P-glycoprotein in human leukemias using monoclonal antibodies
Ausgabe der Zeitschrift
58

Data source: Crossref

Abstract
Overexpression of a Mr 170,000 membrane glycoprotein (P-glycoprotein) is consistently associated with multidrug resistance in cell lines. Two monoclonal antibodies (Mab) against P-glycoprotein (265/F4 and C 219) were used to examine tumour samples from patients with leukemias for evidence of P-glycoprotein overexpression. High levels of P-glycoprotein (greater than 5% positive cells) were detected with both antibodies in samples from 3 out of 18 patients suggesting that a multidrug resistant phenotype may also occur in human leukemias.
Addresses
  • Department of Experimental Pathology, German Cancer Research Center, Heidelberg.
Autoren
  • J Mattern
  • T Efferth
  • T Efferth
  • M Bak
  • AD Ho
  • M Volm
DOI
10.1007/bf00320777
Externe Identifier
  • PubMed Identifier: 2565123
Open access
false
ISSN
0006-5242
Ausgabe der Veröffentlichung
4
Zeitschrift
Blut
Schlüsselwörter
  • Humans
  • Leukemia
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Antibodies, Monoclonal
  • Binding Sites, Antibody
  • Drug Resistance
  • Phenotype
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
215 - 217
Datum der Veröffentlichung
1989
Status
Published
Datum der Datenerfassung
1989
Titel
Detection of P-glycoprotein in human leukemias using monoclonal antibodies.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
58

Data source: Europe PubMed Central

Abstract
Overexpression of a Mr 170,000 membrane glycoprotein (P-glycoprotein) is consistently associated with multidrug resistance in cell lines. Two monoclonal antibodies (Mab) against P-glycoprotein (265/F4 and C 219) were used to examine tumour samples from patients with leukemias for evidence of P-glycoprotein overexpression. High levels of P-glycoprotein (greater than 5% positive cells) were detected with both antibodies in samples from 3 out of 18 patients suggesting that a multidrug resistant phenotype may also occur in human leukemias.
Autoren
  • J Mattern
  • T Efferth
  • M Bak
  • AD Ho
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/2565123
DOI
10.1007/BF00320777
ISSN
0006-5242
Ausgabe der Veröffentlichung
4
Zeitschrift
Blut
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antibodies, Monoclonal
  • Binding Sites, Antibody
  • Drug Resistance
  • Humans
  • Leukemia
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Phenotype
Sprache
eng
Country
Germany
Paginierung
215 - 217
Datum der Veröffentlichung
1989
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1989
Titel
Detection of P-glycoprotein in human leukemias using monoclonal antibodies.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
58

Data source: PubMed

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