ACQUIRED DRUG-RESISTANCE IN HUMAN-LUNG CARCINOMA XENOGRAFTS
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- M VOLM
- T EFFERTH
- J MATTERN
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1989AL45600002&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: AL456
- PubMed Identifier: 2818670
- ISSN
- 0004-4172
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
- Paginierung
- 828 - 831
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Titel
- ACQUIRED DRUG-RESISTANCE IN HUMAN-LUNG CARCINOMA XENOGRAFTS
- Sub types
- Article
- Ausgabe der Zeitschrift
- 39-2
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- The development of resistance to vincristine and dactinomycin has been investigated in a human epidermoid lung xenograft line grown in nude mice. With 1 mg/kg BW vincristine and 0.5 mg/kg BW dactinomycin per passage, resistance of the solid tumors was visible already at the second transplantation. The vincristine-resistant subline showed cross-resistance to dactinomycin and doxorubicin, and the dactinomycin-resistant subline only to vincristine. To determine whether multidrug resistance genes were overexpressed in the resistant sublines, slot blots were performed using the cDNA probe pcDR 1.5. Slightly elevated RNA levels could be detected in the vincristine-resistant subline and in the dactinomycin-resistant subline.
- Addresses
- Institute of Experimental Pathology, German Cancer Research Center, Heidelberg.
- Autoren
- M Volm
- T Efferth
- J Mattern
- eISSN
- 1616-7066
- Externe Identifier
- PubMed Identifier: 2818670
- Open access
- false
- ISSN
- 0004-4172
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Arzneimittel-Forschung
- Schlüsselwörter
- Animals
- Mice
- Mice, Nude
- Lung Neoplasms
- Vincristine
- Dactinomycin
- DNA, Neoplasm
- RNA, Neoplasm
- Transplantation, Heterologous
- Neoplasm Transplantation
- Gene Expression Regulation, Neoplastic
- Drug Resistance
- Female
- Sprache
- eng
- Medium
- Paginierung
- 828 - 831
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Datum der Datenerfassung
- 1989
- Titel
- Acquired drug resistance in human lung carcinoma xenografts.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 39
Data source: Europe PubMed Central
- Abstract
- The development of resistance to vincristine and dactinomycin has been investigated in a human epidermoid lung xenograft line grown in nude mice. With 1 mg/kg BW vincristine and 0.5 mg/kg BW dactinomycin per passage, resistance of the solid tumors was visible already at the second transplantation. The vincristine-resistant subline showed cross-resistance to dactinomycin and doxorubicin, and the dactinomycin-resistant subline only to vincristine. To determine whether multidrug resistance genes were overexpressed in the resistant sublines, slot blots were performed using the cDNA probe pcDR 1.5. Slightly elevated RNA levels could be detected in the vincristine-resistant subline and in the dactinomycin-resistant subline.
- Autoren
- M Volm
- T Efferth
- J Mattern
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/2818670
- ISSN
- 0004-4172
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Arzneimittelforschung
- Schlüsselwörter
- Animals
- DNA, Neoplasm
- Dactinomycin
- Drug Resistance
- Female
- Gene Expression Regulation, Neoplastic
- Lung Neoplasms
- Mice
- Mice, Nude
- Neoplasm Transplantation
- RNA, Neoplasm
- Transplantation, Heterologous
- Vincristine
- Sprache
- eng
- Country
- Germany
- Paginierung
- 828 - 831
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1989
- Titel
- Acquired drug resistance in human lung carcinoma xenografts.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 39
Data source: PubMed
- Beziehungen:
- Property of