P-GLYCOPROTEIN EXPRESSION IN TREATED AND UNTREATED HUMAN-BREAST CANCER
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- J SCHNEIDER
- M BAK
- T EFFERTH
- M KAUFMANN
- J MATTERN
- M VOLM
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1989CD41400003&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/bjc.1989.372
- Externe Identifier
- Clarivate Analytics Document Solution ID: CD414
- PubMed Identifier: 2574987
- ISSN
- 0007-0920
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- BRITISH JOURNAL OF CANCER
- Paginierung
- 815 - 818
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Titel
- P-GLYCOPROTEIN EXPRESSION IN TREATED AND UNTREATED HUMAN-BREAST CANCER
- Sub types
- Article
- Ausgabe der Zeitschrift
- 60
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- J Schneider
- M Bak
- Th Efferth
- M Kaufmann
- J Mattern
- M Volm
- DOI
- 10.1038/bjc.1989.372
- eISSN
- 1532-1827
- ISSN
- 0007-0920
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- British Journal of Cancer
- Sprache
- en
- Paginierung
- 815 - 818
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/bjc.1989.372
- Datum der Datenerfassung
- 2023
- Titel
- P-Glycoprotein expression in treated and untreated human breast cancer
- Ausgabe der Zeitschrift
- 60
Data source: Crossref
- Abstract
- The expression of P-glycoprotein in primary and recurrent human breast cancer was investigated by means of immunohistochemistry, using a monoclonal antibody (C219) and the streptavidin-biotin-peroxidase method. Twelve patients received no chemotherapeutic treatment. The other 11 patients were treated with chemotherapy, and all developed clinical resistance to it. No or only minimal reactivity was found in specimens coming from the untreated patients (12 cases) or from patients treated with substances not involved in the multidrug resistance phenomenon (four cases). In contrast, three out of seven tumours from patients treated with multidrug resistance related substances showed clear reactivity (positive staining in more than 20% of the tumour cells). In one of these cases, where specimens of the tumour could be studied before and after treatment, an association between the latter and expression of P-glycoprotein was suggested. Finally, this marked expression of P-glycoprotein only took place in tumours treated over a longer space of time (five courses or more of multidrug resistance related chemotherapy).
- Addresses
- German Cancer Research Centre, Institute of Experimental Pathology, Heidelberg.
- Autoren
- J Schneider
- M Bak
- T Efferth
- M Kaufmann
- J Mattern
- M Volm
- DOI
- 10.1038/bjc.1989.372
- eISSN
- 1532-1827
- Externe Identifier
- PubMed Identifier: 2574987
- PubMed Central ID: PMC2247284
- Open access
- true
- ISSN
- 0007-0920
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- British journal of cancer
- Schlüsselwörter
- Humans
- Breast Neoplasms
- Neoplasm Recurrence, Local
- Blood Proteins
- Membrane Glycoproteins
- Antineoplastic Agents
- Immunoenzyme Techniques
- Drug Resistance
- Female
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Open access status
- Open Access
- Paginierung
- 815 - 818
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 1989
- Titel
- P-glycoprotein expression in treated and untreated human breast cancer.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 60
Files
https://europepmc.org/articles/PMC2247284?pdf=render
Data source: Europe PubMed Central
- Abstract
- The expression of P-glycoprotein in primary and recurrent human breast cancer was investigated by means of immunohistochemistry, using a monoclonal antibody (C219) and the streptavidin-biotin-peroxidase method. Twelve patients received no chemotherapeutic treatment. The other 11 patients were treated with chemotherapy, and all developed clinical resistance to it. No or only minimal reactivity was found in specimens coming from the untreated patients (12 cases) or from patients treated with substances not involved in the multidrug resistance phenomenon (four cases). In contrast, three out of seven tumours from patients treated with multidrug resistance related substances showed clear reactivity (positive staining in more than 20% of the tumour cells). In one of these cases, where specimens of the tumour could be studied before and after treatment, an association between the latter and expression of P-glycoprotein was suggested. Finally, this marked expression of P-glycoprotein only took place in tumours treated over a longer space of time (five courses or more of multidrug resistance related chemotherapy).
- Autoren
- J Schneider
- M Bak
- T Efferth
- M Kaufmann
- J Mattern
- M Volm
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/2574987
- DOI
- 10.1038/bjc.1989.372
- Externe Identifier
- PubMed Central ID: PMC2247284
- ISSN
- 0007-0920
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Br J Cancer
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Blood Proteins
- Breast Neoplasms
- Drug Resistance
- Female
- Humans
- Immunoenzyme Techniques
- Membrane Glycoproteins
- Neoplasm Recurrence, Local
- Sprache
- eng
- Country
- England
- Paginierung
- 815 - 818
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1990
- Titel
- P-glycoprotein expression in treated and untreated human breast cancer.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 60
Data source: PubMed
- Beziehungen:
- Property of