DETECTION OF THE MULTIDRUG RESISTANT PHENOTYPE IN HUMAN-TUMORS BY MONOCLONAL-ANTIBODIES AND THE STREPTAVIDIN BIOTINYLATED PHYCOERYTHRIN COMPLEX METHOD

Publication type:
Journal article
Metadata:
Autoren
  • M VOLM
  • T EFFERTH
  • M BAK
  • AD HO
  • J MATTERN
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1989U077100025&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/0277-5379(89)90213-7
Externe Identifier
  • Clarivate Analytics Document Solution ID: U0771
  • PubMed Identifier: 2565814
ISSN
0277-5379
Ausgabe der Veröffentlichung
4
Zeitschrift
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY
Paginierung
743 - 749
Datum der Veröffentlichung
1989
Status
Published
Titel
DETECTION OF THE MULTIDRUG RESISTANT PHENOTYPE IN HUMAN-TUMORS BY MONOCLONAL-ANTIBODIES AND THE STREPTAVIDIN BIOTINYLATED PHYCOERYTHRIN COMPLEX METHOD
Sub types
  • Article
Ausgabe der Zeitschrift
25

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Manfred Volm
  • Thomas Efferth
  • Mihaly Bak
  • Anthony D Ho
  • Jürgen Mattern
DOI
10.1016/0277-5379(89)90213-7
ISSN
0277-5379
Ausgabe der Veröffentlichung
4
Zeitschrift
European Journal of Cancer and Clinical Oncology
Sprache
en
Paginierung
743 - 749
Datum der Veröffentlichung
1989
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/0277-5379(89)90213-7
Datum der Datenerfassung
2021
Titel
Detection of the multidrug resistant phenotype in human tumours by monoclonal antibodies and the streptavidin-biotinylated phycoerythrin complex method
Ausgabe der Zeitschrift
25

Data source: Crossref

Abstract
The aim of this study was to find out whether the membrane glycoprotein P-170 can be detected in human tumours with both acquired and intrinsic resistance to chemotherapeutic agents using monoclonal antibodies (265/F4 and C219) and the streptavidin-biotinylated phycoerythrin complex method. Pretreated leukaemia cells and untreated lung and ovarian carcinomas were analysed. Two plasmacytomas and one leukaemia expressed high levels of P-glycoprotein, whereas two leukaemias showed moderate, and three leukaemias no expression of this protein. The intrinsic resistance was analysed with a panel of four human epidermoid lung cancer xenografts grown in nude mice. The expression of P-glycoprotein could be correlated with the degree of resistance. In addition, one out of five ovarian carcinomas revealed a high level of P-glycoprotein.
Addresses
  • Department of Experimental Pathology, German Cancer Research Center, Heidelberg.
Autoren
  • M Volm
  • T Efferth
  • T Efferth
  • M Bak
  • AD Ho
  • J Mattern
DOI
10.1016/0277-5379(89)90213-7
eISSN
1878-5980
Externe Identifier
  • PubMed Identifier: 2565814
Open access
false
ISSN
0277-5379
Ausgabe der Veröffentlichung
4
Zeitschrift
European journal of cancer & clinical oncology
Schlüsselwörter
  • Humans
  • Leukemia
  • Ovarian Neoplasms
  • Lung Neoplasms
  • Biotin
  • Phycoerythrin
  • Bacterial Proteins
  • Streptavidin
  • Membrane Glycoproteins
  • Antineoplastic Agents
  • Antibodies, Monoclonal
  • Fluorescent Antibody Technique
  • Drug Resistance
  • Female
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
743 - 749
Datum der Veröffentlichung
1989
Status
Published
Datum der Datenerfassung
1989
Titel
Detection of the multidrug resistant phenotype in human tumours by monoclonal antibodies and the streptavidin-biotinylated phycoerythrin complex method.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
25

Data source: Europe PubMed Central

Abstract
The aim of this study was to find out whether the membrane glycoprotein P-170 can be detected in human tumours with both acquired and intrinsic resistance to chemotherapeutic agents using monoclonal antibodies (265/F4 and C219) and the streptavidin-biotinylated phycoerythrin complex method. Pretreated leukaemia cells and untreated lung and ovarian carcinomas were analysed. Two plasmacytomas and one leukaemia expressed high levels of P-glycoprotein, whereas two leukaemias showed moderate, and three leukaemias no expression of this protein. The intrinsic resistance was analysed with a panel of four human epidermoid lung cancer xenografts grown in nude mice. The expression of P-glycoprotein could be correlated with the degree of resistance. In addition, one out of five ovarian carcinomas revealed a high level of P-glycoprotein.
Autoren
  • M Volm
  • T Efferth
  • M Bak
  • AD Ho
  • J Mattern
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/2565814
DOI
10.1016/0277-5379(89)90213-7
ISSN
0277-5379
Ausgabe der Veröffentlichung
4
Zeitschrift
Eur J Cancer Clin Oncol
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Bacterial Proteins
  • Biotin
  • Drug Resistance
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Leukemia
  • Lung Neoplasms
  • Membrane Glycoproteins
  • Ovarian Neoplasms
  • Phycoerythrin
  • Streptavidin
Sprache
eng
Country
England
Paginierung
743 - 749
Datum der Veröffentlichung
1989
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1989
Titel
Detection of the multidrug resistant phenotype in human tumours by monoclonal antibodies and the streptavidin-biotinylated phycoerythrin complex method.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
25

Data source: PubMed

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