RELATIONSHIP OF DNA PLOIDY TO CHEMORESISTANCE OF TUMORS AS MEASURED BY INVITRO TESTS

Publication type:
Journal article
Metadata:
Autoren
  • M VOLM
  • T EFFERTH
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1990CX60200010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/cyto.990110311
Externe Identifier
  • Clarivate Analytics Document Solution ID: CX602
  • PubMed Identifier: 1971209
ISSN
0196-4763
Ausgabe der Veröffentlichung
3
Zeitschrift
CYTOMETRY
Paginierung
406 - 410
Datum der Veröffentlichung
1990
Status
Published
Titel
RELATIONSHIP OF DNA PLOIDY TO CHEMORESISTANCE OF TUMORS AS MEASURED BY INVITRO TESTS
Sub types
  • Article
Ausgabe der Zeitschrift
11

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>To examine whether patients with aneuploid tumors might derive more benefit from chemotherapy than would patients with diploid tumors, predictive tests for determining resistance in human tumors were carried out and the test results compared with the DNA ploidy of the corresponding tumors. Multidrug‐resistance in 15 kidney carcinomas grown as primary cultures was determined by immunofluorescence by Mab C219, which is specific for the plasma membrane glycoprotein P‐170, and by the use of tritiated nucleotide incorporation after addition of doxorubicin. Aneuploid tumors had a higher tendency to be more sensitive than diploid tumors, but the correlation was not significant. This was confirmed by reanalyzing our earlier data on ovarian and lung cancers. In conclusion, DNA measurement using flow cytometry does not appear to be a suitable tool for prediction of resistance of human tumors to chemotherapy.</jats:p>
Autoren
  • Manfred Volm
  • Thomas Efferth
DOI
10.1002/cyto.990110311
eISSN
1097-0320
ISSN
0196-4763
Ausgabe der Veröffentlichung
3
Zeitschrift
Cytometry
Sprache
en
Online publication date
2005
Paginierung
406 - 410
Datum der Veröffentlichung
1990
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/cyto.990110311
Datum der Datenerfassung
2023
Titel
Relationship of DNA ploidy to chemoresistance of tumors as measured by in vitro tests
Ausgabe der Zeitschrift
11

Data source: Crossref

Abstract
To examine whether patients with aneuploid tumors might derive more benefit from chemotherapy than would patients with diploid tumors, predictive tests for determining resistance in human tumors were carried out and the test results compared with the DNA ploidy of the corresponding tumors. Multidrug-resistance in 15 kidney carcinomas grown as primary cultures was determined by immunofluorescence by Mab C219, which is specific for the plasma membrane glyco-protein P-170, and by the use of tritiated nucleotide incorporation after addition of doxorubicin. Aneuploid tumors had a higher tendency to be more sensitive than diploid tumors, but the correlation was not significant. This was confirmed by reanalyzing our earlier data on ovarian and lung cancers. In conclusion, DNA measurement using flow cytometry does not appear to be a suitable tool for prediction of resistance of human tumors to chemotherapy.
Addresses
  • Department of Experimental Pathology, German Cancer Research Center, Heidelberg.
Autoren
DOI
10.1002/cyto.990110311
eISSN
1097-0320
Externe Identifier
  • PubMed Identifier: 1971209
Open access
false
ISSN
0196-4763
Ausgabe der Veröffentlichung
3
Zeitschrift
Cytometry
Schlüsselwörter
  • Cell Line
  • Humans
  • Carcinoma
  • Ovarian Neoplasms
  • Lung Neoplasms
  • Kidney Neoplasms
  • Doxorubicin
  • Membrane Glycoproteins
  • Antineoplastic Agents
  • Flow Cytometry
  • Drug Screening Assays, Antitumor
  • Immunohistochemistry
  • Predictive Value of Tests
  • Drug Resistance
  • Ploidies
  • Female
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
406 - 410
Datum der Veröffentlichung
1990
Status
Published
Datum der Datenerfassung
1990
Titel
Relationship of DNA ploidy to chemoresistance of tumors as measured by in vitro tests.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
11

Data source: Europe PubMed Central

Abstract
To examine whether patients with aneuploid tumors might derive more benefit from chemotherapy than would patients with diploid tumors, predictive tests for determining resistance in human tumors were carried out and the test results compared with the DNA ploidy of the corresponding tumors. Multidrug-resistance in 15 kidney carcinomas grown as primary cultures was determined by immunofluorescence by Mab C219, which is specific for the plasma membrane glyco-protein P-170, and by the use of tritiated nucleotide incorporation after addition of doxorubicin. Aneuploid tumors had a higher tendency to be more sensitive than diploid tumors, but the correlation was not significant. This was confirmed by reanalyzing our earlier data on ovarian and lung cancers. In conclusion, DNA measurement using flow cytometry does not appear to be a suitable tool for prediction of resistance of human tumors to chemotherapy.
Autoren
  • M Volm
  • T Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1971209
DOI
10.1002/cyto.990110311
ISSN
0196-4763
Ausgabe der Veröffentlichung
3
Zeitschrift
Cytometry
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Carcinoma
  • Cell Line
  • Doxorubicin
  • Drug Resistance
  • Drug Screening Assays, Antitumor
  • Female
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms
  • Lung Neoplasms
  • Membrane Glycoproteins
  • Ovarian Neoplasms
  • Ploidies
  • Predictive Value of Tests
Sprache
eng
Country
United States
Paginierung
406 - 410
Datum der Veröffentlichung
1990
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1990
Titel
Relationship of DNA ploidy to chemoresistance of tumors as measured by in vitro tests.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
11

Data source: PubMed

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