DETECTION OF DRUG-RESISTANCE AND P-GLYCOPROTEIN IN HUMAN RENAL-CELL CARCINOMAS

Publication type:
Journal article
Metadata:
Autoren
  • M BAK
  • T EFFERTH
  • G MICKISCH
  • J MATTERN
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1990CP96500018&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: CP965
  • PubMed Identifier: 1969346
ISSN
0302-2838
Ausgabe der Veröffentlichung
1
Zeitschrift
EUROPEAN UROLOGY
Paginierung
72 - &
Datum der Veröffentlichung
1990
Status
Published
Titel
DETECTION OF DRUG-RESISTANCE AND P-GLYCOPROTEIN IN HUMAN RENAL-CELL CARCINOMAS
Sub types
  • Article
Ausgabe der Zeitschrift
17

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • M Bak, Jr.
  • T Efferth
  • G Mickisch
  • J Mattern
  • M Volm
DOI
10.1159/000464005
eISSN
1873-7560
ISSN
0302-2838
Ausgabe der Veröffentlichung
1
Zeitschrift
European Urology
Sprache
en
Online publication date
2017
Paginierung
72 - 75
Datum der Veröffentlichung
1990
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1159/000464005
Datum der Datenerfassung
2019
Titel
Detection of Drug Resistance and P-Glycoprotein in Human Renal Cell Carcinomas
Ausgabe der Zeitschrift
17

Data source: Crossref

Abstract
Expression of the multidrug-resistance gene product P-glycoprotein (P-170) was screened in 21 untreated human renal cell carcinomas using monoclonal antibodies (265/F4, C219) and immunoperoxidase staining. The inherent drug resistance of the same samples against doxorubicin was established by a short-term chemoresistance test in order to investigate the association between the expression of P-170 and intrinsic drug resistance in kidney cancers. P-glycoprotein could be demonstrated in 10 cases. Using the short-term test for predicting resistance, 17 resistant and 4 sensitive cancers were found. In vitro 10 of 17 resistant tumors revealed an increase of P-glycoprotein. On the other hand, in the sensitive tumor in vitro, an expression of P-glycoprotein could not be demonstrated. This investigation reveals that intrinsic drug resistance exists in many renal cell carcinomas and it is associated at least in part with increased expression of P-glycoprotein. The immunohistochemical results suggest that the presence of the P-glycoprotein may be useful as a marker for screening the multidrug-resistant phenotype in renal cell carcinomas and as an indicator of the therapeutic efficacy of multidrug-resistant kidney cancers.
Addresses
  • German Cancer Research Center, Institute of Experimental Pathology, Heidelberg, FRG.
Autoren
  • M Bak
  • T Efferth
  • G Mickisch
  • J Mattern
  • M Volm
DOI
10.1159/000464005
eISSN
1873-7560
Externe Identifier
  • PubMed Identifier: 1969346
Open access
false
ISSN
0302-2838
Ausgabe der Veröffentlichung
1
Zeitschrift
European urology
Schlüsselwörter
  • Humans
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Doxorubicin
  • Membrane Glycoproteins
  • Immunoenzyme Techniques
  • Drug Resistance
  • Aged
  • Middle Aged
  • Female
  • Male
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
72 - 75
Datum der Veröffentlichung
1990
Status
Published
Datum der Datenerfassung
1990
Titel
Detection of drug resistance and P-glycoprotein in human renal cell carcinomas.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
17

Data source: Europe PubMed Central

Abstract
Expression of the multidrug-resistance gene product P-glycoprotein (P-170) was screened in 21 untreated human renal cell carcinomas using monoclonal antibodies (265/F4, C219) and immunoperoxidase staining. The inherent drug resistance of the same samples against doxorubicin was established by a short-term chemoresistance test in order to investigate the association between the expression of P-170 and intrinsic drug resistance in kidney cancers. P-glycoprotein could be demonstrated in 10 cases. Using the short-term test for predicting resistance, 17 resistant and 4 sensitive cancers were found. In vitro 10 of 17 resistant tumors revealed an increase of P-glycoprotein. On the other hand, in the sensitive tumor in vitro, an expression of P-glycoprotein could not be demonstrated. This investigation reveals that intrinsic drug resistance exists in many renal cell carcinomas and it is associated at least in part with increased expression of P-glycoprotein. The immunohistochemical results suggest that the presence of the P-glycoprotein may be useful as a marker for screening the multidrug-resistant phenotype in renal cell carcinomas and as an indicator of the therapeutic efficacy of multidrug-resistant kidney cancers.
Autoren
  • M Bak
  • T Efferth
  • G Mickisch
  • J Mattern
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1969346
DOI
10.1159/000464005
ISSN
0302-2838
Ausgabe der Veröffentlichung
1
Zeitschrift
Eur Urol
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Aged
  • Carcinoma, Renal Cell
  • Doxorubicin
  • Drug Resistance
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Kidney Neoplasms
  • Male
  • Membrane Glycoproteins
  • Middle Aged
Sprache
eng
Country
Switzerland
Paginierung
72 - 75
Datum der Veröffentlichung
1990
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1990
Titel
Detection of drug resistance and P-glycoprotein in human renal cell carcinomas.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
17

Data source: PubMed

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